Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Matthew J. LeBaron"'
Autor:
Lynea Murphy, Matthew J. LeBaron, Kamin Johnson, Reza J. Rasoulpour, Xiujuan Wang, Jessica LaRocca
Publikováno v:
Frontiers in Toxicology, Vol 3 (2021)
Nitrapyrin, a nitrification inhibitor, produces liver tumors in B6C3F1 mice. In a 2-year oncogenicity study, increased incidence of mice with hepatocellular tumors was observed following exposure to 125 (females only) or 250 mg/kg/day (males and fema
Externí odkaz:
https://doaj.org/article/4739585540144fb7bdb11c9f0f13b2e9
Autor:
Jessica L. LaRocca, Reza J. Rasoulpour, B. Bhaskar Gollapudi, David L. Eisenbrandt, Lynea A. Murphy, Matthew J. LeBaron
Publikováno v:
Toxicology Reports, Vol 4, Iss , Pp 586-597 (2017)
Nitrapyrin, a nitrification inhibitor, produces liver tumors in mice at high doses. Several experiments were performed to investigate molecular, cellular, and apical endpoints to define the key events leading to the tumor formation. These data suppor
Externí odkaz:
https://doaj.org/article/dfd60cd8ac9e413989fb8d281f02e406
Autor:
Masaaki Miyazawa, Raja S. Settivari, Matthew J. LeBaron, Mary Sue Marty, Hideyuki Mizumachi, Hitoshi Sakaguchi
Publikováno v:
Journal of Applied Toxicology. 41:915-927
The regulatory community is transitioning to the use of nonanimal methods for dermal sensitization assessments; however, some in vitro assays have limitations in their domain of applicability depending on the properties of chemicals being tested. Thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0ec2e50c7b2a3ff8a44261f1c221e5a
https://doi.org/10.1002/jat.4076
https://doi.org/10.1002/jat.4076
Publikováno v:
Journal of Applied Toxicology. 41:362-374
1,2-dichloroethane (DCE or EDC) is a chlorinated hydrocarbon used as a chemical intermediate, including in the synthesis of polyvinyl chloride. Although DCE has induced tumors in both rats and mice, the overall weight-of-evidence suggests a lack of i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fbaa970118cd397400346b0dbf7e5a3
https://doi.org/10.1002/jat.4048
https://doi.org/10.1002/jat.4048
Publikováno v:
Applied In Vitro Toxicology. 5:187-195
Introduction: Reliable and effective predictions of hepatotoxicity resulting from repeated exposure to chemicals are of critical importance for the safety assessment of chemicals; however, in vitro...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5fda4a41e29ed32d959dfaaad99c2ca6
https://doi.org/10.1089/aivt.2019.0008
https://doi.org/10.1089/aivt.2019.0008
Publikováno v:
Environmental and molecular mutagenesis. 62(8)
The in vivo comet assay can evaluate the genotoxic potential of a chemical in theoretically any tissue that can be processed to a single cell suspension. This flexibility enables evaluation of point-of-contact tissues using a relevant route of test m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34058d1560df6acb9705426750c19318
https://pubmed.ncbi.nlm.nih.gov/34369617
https://pubmed.ncbi.nlm.nih.gov/34369617
Publikováno v:
NeuroToxicology. 73:17-30
Developmental neurotoxicity (DNT) is an important endpoint for the safety assessment of chemicals. However, the current in vivo animal model for DNT assessment is resource-intensive and may not fully capture all mechanisms that may be relevant to DNT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::253ff65c2aebf5968e4ddc1e40129622
https://doi.org/10.1016/j.neuro.2019.02.010
https://doi.org/10.1016/j.neuro.2019.02.010
Autor:
Joanna Klapacz, Richard C. Pleus, Matthew J. LeBaron, Lisa M. Corey, Robert A. Budinsky, James Crissman, Rachel M. Golden, Mark Lafranconi
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 119
Studies demonstrate that with sufficient dose and duration, 1,4-dioxane (1,4-DX) induces liver tumors in laboratory rodent models. The available evidence aligns with a threshold-dependent, tumor promotion mode of action (MOA). The MOA and key events
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::745bf5f74f7bf096d00ffc0fc5be03b8
https://pubmed.ncbi.nlm.nih.gov/33189748
https://pubmed.ncbi.nlm.nih.gov/33189748
Publikováno v:
Environmental and Molecular Mutagenesis. 60:42-46
The Pig-a assay is an emerging and promising in vivo method to determine mutagenic potential of chemicals. Since its development in 2008, remarkable progress has been made in harmonizing and characterizing the test procedures, primarily using known m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8965a4f7ae88e3c3176eafdc210d1ff0
https://doi.org/10.1002/em.22232
https://doi.org/10.1002/em.22232
Autor:
Michael Battalora, Werner H. Bomann, M. Aggarwal, Richard C. Peffer, Matthew J. LeBaron, Helen Tinwell, Christoph Werner, Rocky R. Rowe
Publikováno v:
Regulatory Toxicology and Pharmacology. 96:106-120
Methods for investigating the Mode of Action (MoA) for rodent liver tumors via constitutive androstane receptor (CAR) activation are outlined here, based on current scientific knowledge about CAR and feedback from regulatory agencies globally. The ke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::436308cc441e4da351abf6c05b0a16d9
https://doi.org/10.1016/j.yrtph.2018.04.001
https://doi.org/10.1016/j.yrtph.2018.04.001