Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Matthew J. J. Rose-Zerilli"'
Autor:
Christopher J. Hanley, Sara Waise, Matthew J. Ellis, Maria A. Lopez, Wai Y. Pun, Julian Taylor, Rachel Parker, Lucy M. Kimbley, Serena J. Chee, Emily C. Shaw, Jonathan West, Aiman Alzetani, Edwin Woo, Christian H. Ottensmeier, Matthew J. J. Rose-Zerilli, Gareth J. Thomas
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Fibroblast heterogeneity is a prominent but poorly understood feature of solid tumours. Here three major fibroblast subpopulations in non-small cell lung cancer are identified and characterised through single cell RNA-sequencing, multiplexed immunohi
Externí odkaz:
https://doaj.org/article/90c9737e349b4a0f860180335c1700ab
Autor:
Elena Mylonas, Kenichi Yoshida, Mareike Frick, Kaja Hoyer, Friederike Christen, Jaspal Kaeda, Matthias Obenaus, Daniel Noerenberg, Cornelius Hennch, Willy Chan, Yotaro Ochi, Yuichi Shiraishi, Yusuke Shiozawa, Thorsten Zenz, Christopher C. Oakes, Birgit Sawitzki, Michaela Schwarz, Lars Bullinger, Philipp le Coutre, Matthew J. J. Rose-Zerilli, Seishi Ogawa, Frederik Damm
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Myelofibrosis is a myeloproliferative neoplasm. Here, the authors show the clonal evolution of myelofibrosis during JAK inhibitor therapy, revealing how the treatment results in an increase in clonal complexity and a gain of RAS pathway mutations.
Externí odkaz:
https://doaj.org/article/7e23582169274e9ab60ff7109190fa37
Autor:
Fereshteh Izadi, Benjamin P. Sharpe, Stella P. Breininger, Maria Secrier, Jane Gibson, Robert C. Walker, Saqib Rahman, Ginny Devonshire, Megan A. Lloyd, Zoë S. Walters, Rebecca C. Fitzgerald, Matthew J. J. Rose-Zerilli, Tim J. Underwood, on behalf of OCCAMS
Publikováno v:
Cancers, Vol 13, Iss 14, p 3394 (2021)
Neoadjuvant therapy followed by surgery is the standard of care for locally advanced esophageal adenocarcinoma (EAC). Unfortunately, response to neoadjuvant chemotherapy (NAC) is poor (20–37%), as is the overall survival benefit at five years (9%).
Externí odkaz:
https://doaj.org/article/272c0a77dc0247cdaad2470384728573
Autor:
Christopher Rushton, Wolfram Klapper, Jonathan C. Strefford, Cathy Burton, Mark S. Cragg, Ryan D. Morin, Stephen A. Beers, Andrea Knapp, Malgorzata Nowicka, Christopher R. Bolen, Chern Lee, Chantal E. Hargreaves, Laura K. Hilton, Pedro Farinha, Matthew J. Carter, Margaret Ashton-Key, Matthew J. J. Rose-Zerilli, Kathleen N. Potter, Graham W. Slack, Maurizio Martelli, Christian Klein, Mikkel Z. Oestergaard, Umberto Vitolo, Laurie H. Sehn, Farheen Mir, Marek Trneny, Russell Foxall, David W. Scott
Publikováno v:
Blood Adv
Fc γ receptor IIB (FcγRIIB) is an inhibitory molecule capable of reducing antibody immunotherapy efficacy. We hypothesized its expression could confer resistance in patients with diffuse large B-cell lymphoma (DLBCL) treated with anti-CD20 monoclon
Autor:
Bradleigh Whitton, Simon J. Crabb, Graham Packham, Matthew J. J. Rose-Zerilli, Haruko Okamoto
Publikováno v:
Mol Cancer Ther
Prostate cancer is critically dependent on androgen receptor (AR) signaling. Despite initial responsiveness to androgen deprivation, most patients with advanced prostate cancer subsequently progress to a clinically aggressive castrate-resistant prost
Autor:
Christopher C. Oakes, Elena Mylonas, Yusuke Shiozawa, Lars Bullinger, Matthias Obenaus, Daniel Noerenberg, Mareike Frick, Michaela Schwarz, Matthew J. J. Rose-Zerilli, Kenichi Yoshida, Friederike Christen, Yotaro Ochi, Willy Chan, Frederik Damm, Jaspal Kaeda, Philipp le Coutre, Yuichi Shiraishi, Seishi Ogawa, Thorsten Zenz, Birgit Sawitzki, Kaja Hoyer, Cornelius Hennch
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications
Cancer development is an evolutionary genomic process with parallels to Darwinian selection. It requires acquisition of multiple somatic mutations that collectively cause a malignant phenotype and continuous clonal evolution is often linked to tumor
Autor:
Zoë S. Walters, Robert C. Walker, Ginny Devonshire, Stella P. Breininger, Megan Lloyd, Jane Gibson, Matthew J. J. Rose-Zerilli, Saqib Rahman, Rebecca C. Fitzgerald, Timothy J. Underwood, Fereshteh Izadi, Benjamin P. Sharpe, Maria Secrier
Publikováno v:
Cancers
Volume 13
Issue 14
Cancers, Vol 13, Iss 3394, p 3394 (2021)
Volume 13
Issue 14
Cancers, Vol 13, Iss 3394, p 3394 (2021)
Neoadjuvant therapy followed by surgery is the standard of care for locally advanced esophageal adenocarcinoma (EAC). Unfortunately, response to neoadjuvant chemotherapy (NAC) is poor (20–37%), as is the overall survival benefit at five years (9%).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46fd77398b343d1c589f308cf86bb990
https://www.repository.cam.ac.uk/handle/1810/325442
https://www.repository.cam.ac.uk/handle/1810/325442
Autor:
Timothy J. Underwood, Jonathan Butement, Marta E Polak, Maaike S. A. Jongen, Andres F. Vallejo, Bhavwanti Sheth, Simon I. R. Lane, Rachel Parker, Ben D. MacArthur, Rosanna C.G. Smith, Matthew J. J. Rose-Zerilli, Jack Harrington, Patrick S. Stumpf, Luis Blay Esteban, Jonathan West
The future of single cell diversity screens involves ever-larger sample sizes, dictating the need for higher throughput methods with low analytical noise to accurately describe the nature of the cellular system. Current approaches are limited by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b978739ab39f9032cfb38584f3333c2
https://doi.org/10.1101/2021.04.08.439026
https://doi.org/10.1101/2021.04.08.439026
Autor:
Robert C. Walker, Megan Lloyd, Zoë S. Walters, Timothy J. Underwood, Saqib Rahman, Ginny Devonshire, Fereshteh Izadi, Maria Secrier, Stella P. Breininger, Benjamin P. Sharpe, Matthew J. J. Rose-Zerilli, Jane Gibson, Rebecca C. Fitzgerald
Neoadjuvant therapy followed by surgery is the standard of care for locally advanced esophageal adenocarcinoma (EAC). Unfortunately, response to neoadjuvant chemotherapy (NAC) is poor (P=0.036) and elevated copy number variation in non-responders (28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8812d11d5018aebbe37a747a77683a4b
https://doi.org/10.1101/2021.03.26.437144
https://doi.org/10.1101/2021.03.26.437144
Autor:
Jonathan West, Christian H. Ottensmeier, Rachel Parker, Oliver Wood, Sara Waise, David Layfield, Gareth J. Thomas, Matthew J. J. Rose-Zerilli, Christopher J. Hanley
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports
SCIENTIFIC REPORTS
Scientific Reports
SCIENTIFIC REPORTS
Single-cell RNA sequencing (scRNA-Seq) provides a valuable platform for characterising multicellular ecosystems. Fibroblasts are a heterogeneous cell type involved in many physiological and pathological processes, but remain poorly-characterised. Ana