P-selectin mobility undergoes a sol-gel transition as it diffuses from exocytosis sites into the cell membrane

Autor: Nicola Hellen, Gregory I. Mashanov, Ianina L. Conte, Sophie le Trionnaire, Victor Babich, Laura Knipe, Alamin Mohammed, Kazim Ogmen, Silvia Martin-Almedina, Katalin Török, Matthew J. Hannah, Justin E. Molloy, Tom Carter

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)

P-selectin recruits leucocytes to regions of blood vessel damage. Using single molecule imaging, we find newly secreted P-selectin spreads rapidly across the plasma membrane and then becomes immobilized and better-suited to leucocyte capture.

Externí odkaz: https://doaj.org/article/432e60a79f5b4b69a0d8124022f3c9bb

Supplementary data on virus-like particles in the brainstem of Parkinson’s disease patients and controls [version 2; peer review: 2 approved]

Autor: Robert R. Dourmashkin, Sherman A. McCall, Peter Locker, Matthew J. Hannah

Publikováno v: F1000Research, Vol 9 (2022)

In this study, we present 77 transmission electron microscopy (TEM) images of human brainstem tissue from 11 cases of late onset Parkinson’s disease (PD). The tissues were fixed, embedded, sectioned, and stained for TEM application. In addition, we

Externí odkaz: https://doaj.org/article/d120635e080b45a386d5805b7282cdf5

Altered Storage and Function of von Willebrand Factor in Human Cardiac Microvascular Endothelial Cells Isolated from Recipient Transplant Hearts

Autor: Athinoula Meli, Ann McCormack, Ianina Conte, Qu Chen, James Streetley, Marlene L. Rose, Ruben Bierings, Matthew J. Hannah, Justin E. Molloy, Peter B. Rosenthal, Tom Carter

Publikováno v: International Journal of Molecular Sciences, 24(5):4553. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences
Volume 24
Issue 5
Pages: 4553

The assembly of von Willebrand factor (VWF) into ordered helical tubules within endothelial Weibel–Palade bodies (WPBs) is required for the efficient deployment of the protein at sites ofvascular injury. VWF trafficking and storage are sensitive to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75dccba97a4b4387bb753a56d2c3746e
https://pure.eur.nl/en/publications/9c9f3d4b-e881-43e9-925c-5f2ba9665e62

Virucidal efficacy of guanidine-free inactivants and rapid test buffers against SARS-CoV-2

Autor: Christopher Burton, Matthew J. Hannah, Nicole Green, Neil Woodford, Hubert Buczkowski, Patricia A. Cane, Katherine Davies, Peter Spencer, Tracy Beetar-King, Matthew Jones, Rhea Strachan, Allen D. G. Roberts, Nipunadi Hettiarachchi, Stephen R. Welch, Ulrike Arnold, Christine B. Bruce, Marian J Killip

Publikováno v: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)

A pathogen inactivation step during collection or processing of clinical samples has the potential to reduce infectious risks associated with diagnostic procedures. It is essential that these inactivation methods are demonstrated to be effective, par

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7af84cc1ae106fdd239c87ea6bfa2db1
https://pubmed.ncbi.nlm.nih.gov/34862448

P-selectin mobility undergoes a sol-gel transition as it diffuses from exocytosis sites into the cell membrane

Autor: Nicola Hellen, Gregory I. Mashanov, Ianina L. Conte, Sophie le Trionnaire, Victor Babich, Laura Knipe, Alamin Mohammed, Kazim Ogmen, Silvia Martin-Almedina, Katalin Török, Matthew J. Hannah, Justin E. Molloy, Tom Carter

Publikováno v: Nature communications. 13(1)

In response to vascular damage, P-selectin molecules are secreted onto the surface of cells that line our blood vessels. They then serve as mechanical anchors to capture leucocytes from the blood stream. Here, we track individual P-selectin molecules

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e62fcd2184d31de1b188a7882415ef57
https://pubmed.ncbi.nlm.nih.gov/35641503