Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Matthew J. Gold"'
Autor:
Mainak Chakraborty, Kevin Chu, Annie Shrestha, Xavier S. Revelo, Xiangyue Zhang, Matthew J. Gold, Saad Khan, Megan Lee, Camille Huang, Masoud Akbari, Fanta Barrow, Yi Tao Chan, Helena Lei, Nicholas K. Kotoulas, Juan Jovel, Chiara Pastrello, Max Kotlyar, Cynthia Goh, Evangelos Michelakis, Xavier Clemente-Casares, Pamela S. Ohashi, Edgar G. Engleman, Shawn Winer, Igor Jurisica, Sue Tsai, Daniel A. Winer
Publikováno v:
Cell Reports, Vol 34, Iss 2, Pp 108609- (2021)
Summary: Stiffness in the tissue microenvironment changes in most diseases and immunological conditions, but its direct influence on the immune system is poorly understood. Here, we show that static tension impacts immune cell function, maturation, a
Externí odkaz:
https://doaj.org/article/2bdc05ee448647c1a7a0d51fb5a28476
Autor:
Andrew J. Elia, Matthew J. Gold, Carlos Garcia-Batres, Megan E Himmel, Kelly Tai, Alisha R. Elford, Pamela S. Ohashi, Charles W. Tran
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 12, p e0244366 (2020)
PLoS ONE, Vol 15, Iss 12, p e0244366 (2020)
Dendritic cells are sentinels of the immune system and represent a key cell in the activation of the adaptive immune response. Hypoxia-inducible factor 1 alpha (HIF-1α)–a crucial oxygen sensor stabilized during hypoxic conditions–has been shown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8275bbfa2a0355d8b5514030e7dfd554
http://europepmc.org/articles/PMC7775062
http://europepmc.org/articles/PMC7775062
Autor:
SeongJun Han, Zhe Qi Liu, Douglas C. Chung, Michael St. Paul, Carlos R. Garcia-Batres, Azin Sayad, Alisha R. Elford, Matthew J. Gold, Natasha Grimshaw, Pamela S. Ohashi
Publikováno v:
Cancer immunology research. 10(4)
Regulatory T cells (Treg) are an integral component of the adaptive immune system that negatively affect antitumor immunity. Here, we investigated the role of the E3 ubiquitin ligase casitas B-lineage lymphoma-b (Cbl-b) in establishing CD8+ T-cell re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6297e6f8ec3d8efd5a360fa637a60208
https://pubmed.ncbi.nlm.nih.gov/35362047
https://pubmed.ncbi.nlm.nih.gov/35362047
Autor:
Natasha Grimshaw, Azin Sayad, Carlos Garcia-Batres, SeongJun Han, Michael St. Paul, Matthew J. Gold, Zhe Qi Liu, Douglas C. Chung, Pamela S. Ohashi, Alisha R. Elford
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Adoptive T cell therapy (ACT) is reaching its potential in multiple malignancies. However, anti-tumor T cell responses can be attenuated by suppressive cells in the tumor microenvironment, such as CD4+FoxP3+ regulatory T (Treg) cells. Depl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5de9d18e8c74e1486c1417189e372db6
https://doaj.org/article/fec73fd3f4c648a99f87f5e25d408178
https://doaj.org/article/fec73fd3f4c648a99f87f5e25d408178
Autor:
Shawn Stapleton, Ali Vedadi, Michael Milosevic, Matthew J. Gold, Christine Allen, David A. Jaffray, Charles W. Tran, Trevor D. McKee, Michael Dunne, Pamela S. Ohashi
Publikováno v:
ACS Nano. 12:7583-7600
Nanomedicine drug delivery systems are capable of transporting significant payloads to solid tumors. However, only a modest increase in antitumor efficacy relative to the standard of care has been observed. In this study, we demonstrate that a single
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf24a5001be6d58290d88757c519239f
https://doi.org/10.1021/acsnano.7b06301
https://doi.org/10.1021/acsnano.7b06301
Autor:
Steven Maltby, Spencer Freeman, Matthew J Gold, Jennifer H E Baker, Andrew I Minchinton, Michael R Gold, Calvin D Roskelley, Kelly M McNagny
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18160 (2011)
Tumor growth and metastasis are determined by the complex interplay of factors, including those intrinsic to tumor cells and extrinsic factors associated with the tumor microenvironment. Our previous work demonstrated key roles for CD34 in the mainte
Externí odkaz:
https://doaj.org/article/a9e584cb1ed74e73b8c48f209839fbea
Autor:
Michael St. Paul, Samuel D. Saibil, SeongJun Han, Kavita Israni-Winger, Scott C. Lien, Rob C. Laister, Azin Sayad, Susanne Penny, Rodabe N. Amaria, Lauren E. Haydu, Carlos R. Garcia-Batres, Meghan Kates, David T. Mulder, Céline Robert-Tissot, Matthew J. Gold, Charles W. Tran, Alisha R. Elford, Linh T. Nguyen, Trevor J. Pugh, Devanand M. Pinto, Jennifer A. Wargo, Pamela S. Ohashi
Publikováno v:
Cell Metabolism. 33:2415-2427.e6
Metabolic programming is intricately linked to the anti-tumor properties of T cells. To study the metabolic pathways associated with increased anti-tumor T cell function, we utilized a metabolomics approach to characterize three different CD8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7863287b3155fd42a888480b87c4d92
https://doi.org/10.1016/j.cmet.2021.11.010
https://doi.org/10.1016/j.cmet.2021.11.010
Autor:
Mitchell J.S. Braam, Alissa Cait, Matthew J. Gold, Timotheus Y.F. Halim, Michael R. Hughes, Menno J. Oudhoff, Fumio Takei, Kyle Burrows, Kelly M. McNagny, David G Rattray, Alistair Chenery, Fabio M.V. Rossi, Frann Antignano, Colby Zaph
Publikováno v:
The Journal of Experimental Medicine
Antignano, Zaph, and collaborators show that the lysine methyltransferase G9a plays a critical role in determining the developmental programs of group 2 and 3 innate lymphoid cells.
Innate lymphoid cells (ILCs) are emerging as important regulato
Innate lymphoid cells (ILCs) are emerging as important regulato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f987ca68fa0d40d754291b3f0ba0bc5
https://doi.org/10.1084/jem.20151646
https://doi.org/10.1084/jem.20151646
Autor:
Philip M. Hansbro, A Le, Don D. Sin, Jay C. Horvat, Christopher Carlsten, Dorota Stefanowicz, S VanEeden, Alexandra C. Brown, Malcolm R. Starkey, H Y Park, Zaridatul Aini Ibrahim, Gang Liu, Matthew J. Gold, Paul Hiebert, Maria B. Sukkar, Kelly M. McNagny, Darryl A. Knight, Jeremy A. Hirota, Andrew Deane
Publikováno v:
Mucosal Immunology. 9:809-820
Exposure to particulate matter (PM), a major component of air pollution, contributes to increased morbidity and mortality worldwide. PM induces innate immune responses and contributes to allergic sensitization, although the mechanisms governing this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe97a163ff50d38f9da644c49d7f79a8
https://doi.org/10.1038/mi.2015.104
https://doi.org/10.1038/mi.2015.104
Publikováno v:
European Journal of Immunology. 46:122-130
In mouse models of infection with the gastrointestinal parasite Trichuris muris, appropriate dendritic-cell (DC) Ag sampling, migration, and presentation to T cells are necessary to mount a protective Th2-polarized adaptive immune response, which is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52b348339bce0a398526732547e5e653
https://doi.org/10.1002/eji.201545628
https://doi.org/10.1002/eji.201545628