Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Matthew J. Gerdin"'
Publikováno v:
Annals of the New York Academy of Sciences. 1144:6-20
Pituitary adenylate cyclase-activating polypeptide (PACAP) is an evolutionarily well conserved neuropeptide with multiple functions in the nervous, endocrine, and immune systems. PACAP provides neuroprotection from ischemia and toxin exposure, is ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::337da825d3d7f16d23746fcf8acee0a8
https://doi.org/10.1196/annals.1418.019
https://doi.org/10.1196/annals.1418.019
Autor:
David Huddleston, Abdel G. Elkahloun, Babru B Samal, Carol Hamelink, Chang-Mei Hsu, Nikolas Stroth, Matthew J. Gerdin, Lee E. Eiden
Publikováno v:
Peptides. 28:1871-1882
Initial PACAP-regulated transcriptomes of PACAP-treated cultured chromaffin cells, and the adrenal gland of wild-type versus PACAP-deficient mice, have been assembled using microarray analysis. These were compared to previously acquired PACAP-regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92df2d98e39e723bc52f2df54a80d3f1
https://doi.org/10.1016/j.peptides.2007.06.013
https://doi.org/10.1016/j.peptides.2007.06.013
Autor:
Monica I. Masana, Moisés A. Rivera-Bermúdez, Margarita L. Dubocovich, Randall L. Hudson, David J. Earnest, Martha U. Gillette, Matthew J. Gerdin
Publikováno v:
The FASEB Journal. 18:1646-1656
The hormone melatonin phase shifts circadian rhythms generated by the mammalian biological clock, the suprachiasmatic nucleus (SCN) of the hypothalamus, through activation of G protein-coupled MT2 melatonin receptors. This study demonstrated that pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d65e96408ae33bfcb82c66ecb6caa2f
https://doi.org/10.1096/fj.03-1339com
https://doi.org/10.1096/fj.03-1339com
Publikováno v:
Biochemical Pharmacology. 67:2023-2030
In mammals, the pineal hormone melatonin activates G protein-coupled MT1 and MT2 melatonin receptors. Acute exposure of recombinant MT1 and MT2 melatonin receptors to supraphysiological concentrations of melatonin differentially regulates these two r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::945340c5cf2bf600ed92d05587f634d3
https://doi.org/10.1016/j.bcp.2004.01.027
https://doi.org/10.1016/j.bcp.2004.01.027
Publikováno v:
Frontiers in Bioscience. 8:d1093-1108
Melatonin (5-methoxy-N-acetyltryptamine), dubbed the hormone of darkness, is released following a circadian rhythm with high levels at night. It provides circadian and seasonal timing cues through activation of G protein-coupled receptors (GPCRs) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e907f3a57c650f963d9700286f8671c2
https://doi.org/10.2741/1089
https://doi.org/10.2741/1089
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 304:931-939
The hormone melatonin mediates a variety of physiological functions in mammals through activation of pharmacologically distinct MT(1) and MT(2) G protein-coupled melatonin receptors. We therefore sought to investigate how the receptors were regulated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb8757f3a8e12a7754697b25e140b7be
https://doi.org/10.1124/jpet.102.044990
https://doi.org/10.1124/jpet.102.044990
Publikováno v:
European Journal of Pharmacology. 449:29-38
In mammals, melatonin activates melatonin MT 1 and MT 2 receptors. Using site-directed mutagenesis and chemical modification, we investigated the role of conserved cysteines in ligand binding. Dithiothreitol inhibited 2-[ 125 I]iodomelatonin binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2711df544c94e348cb5c910be6c66616
https://doi.org/10.1016/s0014-2999(02)01903-9
https://doi.org/10.1016/s0014-2999(02)01903-9
Autor:
Lee E. Eiden, Bruno J. Gonzalez, Anthony Falluel-Morel, Hubert Vaudry, Maribeth V. Eiden, Matthew J. Gerdin, Aurélia Ravni, David Vaudry
The neurotrophic peptide PACAP (pituitary adenylate cyclase-activating polypeptide) elevates cAMP in PC12 cells. Forskolin and dibutyryl cAMP mimic PACAP’s neuritogenic and cell morphological effects, suggesting that they are driven by cAMP. Compar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3987572fe208cb903549682a215351a6
https://europepmc.org/articles/PMC4188547/
https://europepmc.org/articles/PMC4188547/
Autor:
Matthew J. Gerdin, Lee E. Eiden
Publikováno v:
The FASEB Journal. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70a376d03f1d081136ee459666d5c7f7
https://doi.org/10.1096/fasebj.22.1_supplement.728.7
https://doi.org/10.1096/fasebj.22.1_supplement.728.7
Autor:
Lee E. Eiden, Matthew J. Gerdin
Pituitary adenylate cyclase–activating polypeptide (PACAP) is a neuropeptide that elevates adenosine 3′,5′-monophosphate (cyclic AMP, also abbreviated cAMP) to elicit neuritogenesis in PC12 cells. This effect appears to be independent of cAMP-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94f6c0b737c87bd353d355fbe687f3d4
https://europepmc.org/articles/PMC4183209/
https://europepmc.org/articles/PMC4183209/