Zobrazeno 1 - 10
of 162
pro vyhledávání: '"Matthew J. Gaunt"'
Publikováno v:
Organic Process Research & Development. 27:649-658
Development of scalable processes for C(sp3)–H oxidative carbonylation of alkylamines is reported to provide convenient access to the β-lactam scaffol d. A study of the kinetics of the process revealed that the reaction is CO-limited even at ele
Publikováno v:
Chem. 9:216-226
Publikováno v:
Journal of the American Chemical Society. 144:3939-3948
Publikováno v:
Chemical Science. 13:13241-13247
Here, we present a remarkably mild and general initiation protocol for alkyl-radical generation from non-activated alkyl-iodides.
Autor:
Matthew J. Gaunt, Vivian M. Lechner, Manuel Nappi, Patrick J. Deneny, John C. K. Chu, Sarah Folliet
Publikováno v:
Chemical Reviews. 122:1752-1829
Chemically modified biomacromolecules─i.e., proteins, nucleic acids, glycans, and lipids─have become crucial tools in chemical biology. They are extensively used not only to elucidate cellular processes but also in industrial applications, partic
Publikováno v:
Chemical Science
Incorporation of the fluoromethyl group can profoundly influence the physicochemical properties of organic molecules, offering a promising strategy for the discovery of novel pharmaceutical agents. Direct fluoromethylation of unfunctionalized C(sp2)
Publikováno v:
Chemical science. 13(44)
Here, we present a remarkably mild and general initiation protocol for alkyl-radical generation from non-activated alkyl-iodides. An interaction between a silane and an alkyl iodide is excited by irradiation with visible light to trigger carbon-iodid
Publikováno v:
Journal of the American Chemical Society. 142:14169-14177
Alkyl Pd(IV) complexes are frequently invoked in the proposed mechanisms of Pd-catalyzed C(sp3)–H functionalization reactions, though few examples of Pd(IV) complexes containing cyclopalladated sub...
Publikováno v:
Nature
The ubiquity of tertiary alkylamines in pharmaceutical and agrochemical agents, natural products and small-molecule biological probes1,2 has stimulated efforts towards their streamlined synthesis3–9. Arguably the most robust method for the synthesi
Publikováno v:
Trowbridge, A, Walton, S M & Gaunt, M J 2020, ' New Strategies for the Transition-Metal Catalyzed Synthesis of Aliphatic Amines ', Chemical Reviews, vol. 120, no. 5, pp. 2613–2692 . https://doi.org/10.1021/acs.chemrev.9b00462
Transition-metal catalyzed reactions that are able to construct complex aliphatic amines from simple, readily available feedstocks have become a cornerstone of modern synthetic organic chemistry. In light of the ever-increasing importance of aliphati