Zobrazeno 1 - 10
of 167
pro vyhledávání: '"Matthew J. Flick"'
Autor:
Jonathan J. Molina, Kurt N. Kohler, Christopher Gager, Marissa J. Andersen, Ellsa Wongso, Elizabeth R. Lucas, Andrew Paik, Wei Xu, Deborah L. Donahue, Karla Bergeron, Aleksandra Klim, Michael G. Caparon, Scott J. Hultgren, Alana Desai, Victoria A. Ploplis, Matthew J. Flick, Francis J. Castellino, Ana L. Flores-Mireles
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Catheter-associated urinary tract infections (CAUTIs) are amongst the most common nosocomial infections worldwide and are difficult to treat partly due to development of multidrug-resistance from CAUTI-related pathogens. Importantly, CAUTI o
Externí odkaz:
https://doaj.org/article/3cbe7c971bf8491cb4d5b2b0b02ebda0
Autor:
Nayela N. Chowdhury, Yi Yang, Ananya Dutta, Michelle Luo, Zimu Wei, Sara R. Abrahams, Alexey S. Revenko, Fenil Shah, Lindsey A. Miles, Robert J. Parmer, Bas deLaat, Alisa S. Wolberg, James P. Luyendyk, Melissa L. Fishel, Matthew J. Flick
Publikováno v:
Molecular Oncology, Vol 18, Iss 1, Pp 113-135 (2024)
Pancreatic ductal adenocarcinoma (PDAC) is a highly fatal metastatic disease associated with robust activation of the coagulation and fibrinolytic systems. However, the potential contribution of the primary fibrinolytic protease plasminogen to PDAC d
Externí odkaz:
https://doaj.org/article/d7e6f70905c245e1a019d7d8c2f2e56f
Autor:
Leland S. Hu, Fulvio D’Angelo, Taylor M. Weiskittel, Francesca P. Caruso, Shannon P. Fortin Ensign, Mylan R. Blomquist, Matthew J. Flick, Lujia Wang, Christopher P. Sereduk, Kevin Meng-Lin, Gustavo De Leon, Ashley Nespodzany, Javier C. Urcuyo, Ashlyn C Gonzales, Lee Curtin, Erika M. Lewis, Kyle W. Singleton, Timothy Dondlinger, Aliya Anil, Natenael B. Semmineh, Teresa Noviello, Reyna A. Patel, Panwen Wang, Junwen Wang, Jennifer M. Eschbacher, Andrea Hawkins-Daarud, Pamela R. Jackson, Itamar S. Grunfeld, Christian Elrod, Gina L. Mazza, Sam C. McGee, Lisa Paulson, Kamala Clark-Swanson, Yvette Lassiter-Morris, Kris A. Smith, Peter Nakaji, Bernard R. Bendok, Richard S. Zimmerman, Chandan Krishna, Devi P. Patra, Naresh P. Patel, Mark Lyons, Matthew Neal, Kliment Donev, Maciej M. Mrugala, Alyx B. Porter, Scott C. Beeman, Todd R. Jensen, Kathleen M. Schmainda, Yuxiang Zhou, Leslie C. Baxter, Christopher L. Plaisier, Jing Li, Hu Li, Anna Lasorella, C. Chad Quarles, Kristin R. Swanson, Michele Ceccarelli, Antonio Iavarone, Nhan L. Tran
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Sampling restrictions have hindered the comprehensive study of invasive non-enhancing (NE) high-grade glioma (HGG) cell populations driving tumor progression. Here, we present an integrated multi-omic analysis of spatially matched molecular
Externí odkaz:
https://doaj.org/article/a2809ec273b7446289807a553cea6a7f
Autor:
Calvin C. Chan, Isaac T. W. Harley, Paul T. Pfluger, Aurelien Trompette, Traci E. Stankiewicz, Jessica L. Allen, Maria E. Moreno-Fernandez, Michelle S. M. A. Damen, Jarren R. Oates, Pablo C. Alarcon, Jessica R. Doll, Matthew J. Flick, Leah M. Flick, Joan Sanchez-Gurmaches, Rajib Mukherjee, Rebekah Karns, Michael Helmrath, Thomas H. Inge, Stuart P. Weisberg, Sünje J. Pamp, David A. Relman, Randy J. Seeley, Matthias H. Tschöp, Christopher L. Karp, Senad Divanovic
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Interactions between the immune system and adipose tissue contribute to the regulation of body weight, however, the underlying mechanisms remain incompletely understood. Here the authors dissect the role of two structurally and functionally similar i
Externí odkaz:
https://doaj.org/article/1874a0fdf3df440c914731f67be8205d
Autor:
Robert H. Lee, Dorsaf Ghalloussi, Gabriel L. Harousseau, Joseph P. Kenny, Patrick A. Kramer, Fabienne Proamer, Bernhard Nieswandt, Matthew J. Flick, Christian Gachet, Caterina Casari, Anita Eckly, Wolfgang Bergmeier
Publikováno v:
JCI Insight, Vol 7, Iss 8 (2022)
Platelet homeostasis is dependent on a tight regulation of both platelet production and clearance. The small GTPase Rap1 mediates platelet adhesion and hemostatic plug formation. However, Rap1 signaling is also critical for platelet homeostasis as bo
Externí odkaz:
https://doaj.org/article/2186e8e3188e42de854d0ccf9a4a23a7
Autor:
Axel Rosell, Bernhard Moser, Yohei Hisada, Rukesh Chinthapatla, Grace Lian, Yi Yang, Matthew J. Flick, Nigel Mackman
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 4, Iss 6, Pp 1013-1023 (2020)
Abstract Background Western blotting is used to measure protein expression in cells and tissues. Appropriate interpretation of resulting data is contingent upon antibody validation. Objectives We assessed several commercial anti‐human and anti‐mo
Externí odkaz:
https://doaj.org/article/b0393601007b43d7b6980b0a7ad9ae8c
Autor:
Breanne H.Y. Gibson, Matthew T. Duvernay, Stephanie N. Moore‐Lotridge, Matthew J. Flick, Jonathan G. Schoenecker
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 4, Iss 4, Pp 469-480 (2020)
Abstract The musculoskeletal system is critical for movement and the protection of organs. In addition to abrupt injuries, daily physical demands inflict minor injuries, necessitating a coordinated process of repair referred to as the acute‐phase r
Externí odkaz:
https://doaj.org/article/ef606f45d3c84023a06b0b642dcad098
Autor:
Breanne H. Y. Gibson, Colby C. Wollenman, Stephanie N. Moore-Lotridge, Patrick R. Keller, J. Blair Summitt, Alexey R. Revenko, Matthew J. Flick, Timothy S. Blackwell, Jonathan G. Schoenecker
Publikováno v:
JCI Insight, Vol 6, Iss 23 (2021)
Severe injuries, such as burns, provoke a systemic inflammatory response syndrome (SIRS) that imposes pathology on all organs. Simultaneously, severe injury also elicits activation of the fibrinolytic protease plasmin. While the principal adverse out
Externí odkaz:
https://doaj.org/article/a90615824a274fa1b72ec0924b085a18
Autor:
Heather A. Cole, Stephanie N. Moore-Lotridge, Gregory D. Hawley, Richard Jacobson, Masato Yuasa, Leslie Gewin, Jeffry S. Nyman, Matthew J. Flick, Jonathan G. Schoenecker
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Chronic diseases in growing children, such as autoimmune disorders, obesity, and cancer, are hallmarked by musculoskeletal growth disturbances and osteoporosis. Many of the skeletal changes in these children are thought to be secondary to chronic inf
Externí odkaz:
https://doaj.org/article/27c592cdeefc489eb3aba2d56cae271f
Autor:
Sravya Kattula, James R. Byrnes, Sara M. Martin, Lori A. Holle, Brian C. Cooley, Matthew J. Flick, Alisa S. Wolberg
Publikováno v:
Blood Advances, Vol 2, Iss 1, Pp 25-35 (2018)
Abstract: The transglutaminase factor XIII (FXIII) stabilizes clots against mechanical and biochemical disruption and is essential for hemostasis. In vitro and in vivo models of venous thrombosis demonstrate that FXIII mediates clot size by promoting
Externí odkaz:
https://doaj.org/article/a8999cfe33124bea952d858ce07e4bff