Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Matthew J. Fischl"'
Publikováno v:
The Journal of Neuroscience
Medial olivocochlear (MOC) efferent neurons in the brainstem comprise the final stage of descending control of the mammalian peripheral auditory system through axon projections to the cochlea. MOC activity adjusts cochlear gain and frequency tuning,
Autor:
Markus Drexl, Jan M. Deussing, James L. Sinclair, Olga Alexandrova, Conny Kopp-Scheinpflug, Matthew J. Fischl, Margarete A. Ueberfuhr, Sara Pagella
Publikováno v:
The Journal of Physiology
Key points Ongoing, moderate noise exposure does not instantly damage the auditory system but may cause lasting deficits, such as elevated thresholds and accelerated ageing of the auditory system.The neuromodulatory peptide urocortin‐3 (UCN3) is in
Autor:
Matthew J Fischl, R. Michael eBurger
Publikováno v:
Frontiers in Neural Circuits, Vol 8 (2014)
For all neurons, a proper balance of synaptic excitation and inhibition is crucial to effect computational precision. Achievement of this balance is remarkable when one considers factors that modulate synaptic strength operate on multiple overlapping
Externí odkaz:
https://doaj.org/article/574fab5741694e83aeb4b10a60c6bad0
Publikováno v:
J Vis Exp
In vitro slice electrophysiology techniques measure single-cell activity with precise electrical and temporal resolution. Brain slices must be relatively thin to properly visualize and access neurons for patch-clamping or imaging, and in vitro examin
Autor:
Benedikt Grothe, Matthew J. Fischl, Olga Alexandrova, James L. Sinclair, Martin Heβ, Conny Kopp-Scheinpflug, Christian Leibold
Publikováno v:
Journal of Neurophysiology
Plasticity of myelination represents a mechanism to tune the flow of information by balancing functional requirements with metabolic and spatial constraints. The auditory system is heavily myelinated and operates at the upper limits of action potenti
Autor:
Benedikt Grothe, Ian D. Forsythe, James L. Sinclair, Conny Kopp-Scheinpflug, Myriam Schmidt-Pauly, R. Michael Burger, Matthew J. Fischl, Olga Alexandrova
Publikováno v:
Journal of Neurophysiology
The medial superior olive (MSO) is an important brain center that computes sound location by comparing small differences in arrival time at the two ears. The MSO is investigated for its specializations for processing with extreme temporal precision.
Autor:
Benedikt Grothe, Matthew J. Fischl, Leander Mrowka, Matthias H. Hennig, Olga Alexandrova, Carina Kaltenbach, Ezhilarasan Rajaram, Conny Kopp-Scheinpflug
Publikováno v:
Rajaram, E, Kaltenbach, C, Fischl, M J, Mrowka, L, Alexandrova, O, Grothe, B, Hennig, M H & Kopp-Scheinpflug, C 2019, ' Slow NMDA-Mediated Excitation Accelerates Offset-Response Latencies Generated via a Post-Inhibitory Rebound Mechanism ', eNeuro, vol. 6, no. 3 . https://doi.org/10.1523/ENEURO.0106-19.2019
eNeuro
eNeuro
In neural circuits, action potentials (spikes) are conventionally caused by excitatory inputs whereas inhibitory inputs reduce or modulate neuronal excitability. We previously showed that neurons in the superior paraolivary nucleus (SPN) require sole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c776ae8fe8a13aa6115d7702fe2a98fd
https://www.pure.ed.ac.uk/ws/files/97164601/Slow_NMDA_mediated_HENNIG_DoA020519_VoR_CC_BY.pdf
https://www.pure.ed.ac.uk/ws/files/97164601/Slow_NMDA_mediated_HENNIG_DoA020519_VoR_CC_BY.pdf
Autor:
Hilde Wohlfrom, Alisha L. Nabel, Conny Kopp-Scheinpflug, Benedikt Grothe, Michael Pecka, Matthew J. Fischl, Olga Alexandrova, Annette Stange-Marten, James L. Sinclair
Publikováno v:
Proceedings of the National Academy of Sciences. 114
Precise timing of synaptic inputs is a fundamental principle of neural circuit processing. The temporal precision of postsynaptic input integration is known to vary with the computational requirements of a circuit, yet how the timing of action potent
Publikováno v:
Journal of Neurophysiology. 111:565-572
Localization of low-frequency acoustic stimuli is processed in dedicated neural pathways where coincidence-detecting neurons compare the arrival time of sound stimuli at the two ears, or interaural time disparity (ITD). ITDs occur in the submilliseco
Publikováno v:
The Journal of Physiology. 590:3047-3066
Interaural time disparities (ITDs) are the primary cues for localisation of low-frequency sound stimuli. ITDs are computed by coincidence-detecting neurones in the medial superior olive (MSO) in mammals. Several previous studies suggest that control