Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Matthew J. Durbin"'
Autor:
Carole J. R. Bataille, Alan M. Jones, Simon Byrne, Abigail R R Guillermo, Graham Michael Wynne, Angela J. Russell, J.M. Elkins, Isabel V.L. Wilkinson, Stefan Knapp, Camilo E. Quevedo, Matthew J. Durbin, Roderick G. Walker, Stephen G. Davies, Anna Nadali
Publikováno v:
Bioorganic & Medicinal Chemistry. 28:115724
We have previously reported the discovery of a series of rhodanine-based inhibitors of the PIM family of serine/threonine kinases. Here we described the optimisation of those compounds to improve their physicochemical and ADME properties as well as r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2efa894909bb30ba05eb5216e979c44
https://doi.org/10.1016/j.bmc.2020.115724
https://doi.org/10.1016/j.bmc.2020.115724
Autor:
Carole J. R. Bataille, Matthew J. Durbin, Angela J. Russell, Anna Nadali, Méabh B. Brennan, Robert Westwood, Stefan Knapp, Oleg Fedorov, Roderick G. Walker, Kilian Huber, Graham Michael Wynne, Stephen G. Davies, Alan M. Jones, Gu Liu, Camilo E. Quevedo, Simon Byrne
The PIM family of serine/threonine kinases have become an attractive target for anti-cancer drug development, particularly for certain hematological malignancies. Here, we describe the discovery of a series of inhibitors of the PIM kinase family usin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dbafee2ae06cfe33f43c280c5e18964
https://ora.ox.ac.uk/objects/uuid:7b0cdcdc-22cb-46f9-9a3a-f3e33a8b468d
https://ora.ox.ac.uk/objects/uuid:7b0cdcdc-22cb-46f9-9a3a-f3e33a8b468d
Autor:
Matthew J. Durbin, Michael C. Willis
A catalyst generated from Pd(dba)2 and the bulky electron-rich phosphine ligand 2-(dicyclohexylphosphino)-2',4', 6'-tri-i-propyl-1-1'-biphenyl is effective for the alpha-arylation of oxindoles. Generation of the potassium-enolates of a range of oxind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0d1824a3accb89b43478a7a583e72fb
https://doi.org/10.1021/ol800141t
https://doi.org/10.1021/ol800141t
Autor:
Matthew J. Durbin, Angela J. Russell, Stephen G. Davies, Scott J.S. Hartman, Andrew D. Smith, Paul M. Roberts, Ai Matsuno, Steven M. Toms, James E. Thomson
Publikováno v:
Tetrahedron: Asymmetry. 19:2870-2881
Excellent levels of enantiorecognition are displayed by tert-butyl (RS)-6-n-alkyl-cyclohex-1-ene-carboxylates in mutual kinetic resolutions with lithium (RS)-N-benzyl-N-(α-methylbenzyl)amide. Therefore a 50:50 pseudoenantiomeric mixture of lithium (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2bea3dc1bb317a7d4a6655b86f3bf18
https://doi.org/10.1016/j.tetasy.2008.11.019
https://doi.org/10.1016/j.tetasy.2008.11.019
Publikováno v:
Angewandte Chemie International Edition. 44:1543-1545
The combination of three reagents-a tridentate pybox ligand (pybox = pyridine bis(oxazoline)), magnesium perchlorate, and Hunig base (iPr 2EtN)-allows the catalytic generation of a chiral glycine enolate from 1 that undergoes highly enantioselective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95943eedb16f5e64aae747d22cc5328f
https://doi.org/10.1002/anie.200462125
https://doi.org/10.1002/anie.200462125
Autor:
Matthew J. Durbin, Michael C. Willis
Publikováno v:
ChemInform. 39
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7f2452c6fff1e8a726ccc32ca2ad0c7
https://doi.org/10.1002/chin.200835106
https://doi.org/10.1002/chin.200835106
Publikováno v:
ChemInform. 36
The combination of three reagents-a tridentate pybox ligand (pybox = pyridine bis(oxazoline)), magnesium perchlorate, and Hunig base (iPr 2EtN)-allows the catalytic generation of a chiral glycine enolate from 1 that undergoes highly enantioselective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6001eb25a693402d672698fa2e269c4b
https://doi.org/10.1002/chin.200527087
https://doi.org/10.1002/chin.200527087
Publikováno v:
Angewandte Chemie (International ed. in English). 44(10)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d75c4f8c2a329eebfe58c8a638711c28
https://pubmed.ncbi.nlm.nih.gov/15678437
https://pubmed.ncbi.nlm.nih.gov/15678437
Publikováno v:
Chemistry - A European Journal. 18:16585-16585
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d3ce3a153292e56f10ac15d2fab91ae
https://doi.org/10.1002/chem.201290220
https://doi.org/10.1002/chem.201290220
Autor:
Matthew J. Durbin, Michael C. Willis
Publikováno v:
Organic Letters; Apr2008, Vol. 10 Issue 7, p1413-1415, 3p