Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Matthew J. Culyba"'
Autor:
Edwin Chen, Marla G. Shaffer, Robert E. Bilodeau, Raymond E. West, Patrick J. Oberly, Thomas D. Nolin, Matthew J. Culyba
Publikováno v:
mSphere, Vol 8, Iss 5 (2023)
ABSTRACT Persistent infection by Staphylococcus aureus has been linked to the bacterial stringent response (SR), a conserved stress response pathway regulated by the Rel protein. Rel synthesizes (p)ppGpp “alarmones” in response to amino acid star
Externí odkaz:
https://doaj.org/article/0a7a625521164b85a2f0eb26f6ff9117
Publikováno v:
mSphere, Vol 5, Iss 4 (2020)
ABSTRACT Feedback mechanisms are fundamental to the control of physiological responses. One important example in gene regulation, termed negative autoregulation (NAR), occurs when a transcription factor (TF) inhibits its own production through transc
Externí odkaz:
https://doaj.org/article/103b147ae275429c821485614a05cbdf
Autor:
Trevor Selwood, Brian J. Larsen, Charlie Y. Mo, Matthew J. Culyba, Zachary M. Hostetler, Rahul M. Kohli, Allen B. Reitz, Simon D. P. Baugh
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
Many antibiotics, either directly or indirectly, cause DNA damage thereby activating the bacterial DNA damage (SOS) response. SOS activation results in expression of genes involved in DNA repair and mutagenesis, and the regulation of the SOS response
Externí odkaz:
https://doaj.org/article/fc69e9d5be4840acbcfd56e5aaba5e04
Autor:
Charlie Y. Mo, Sara A. Manning, Manuela Roggiani, Matthew J. Culyba, Amanda N. Samuels, Paul D. Sniegowski, Mark Goulian, Rahul M. Kohli
Publikováno v:
mSphere, Vol 1, Iss 4 (2016)
ABSTRACT The bacterial SOS response is a DNA damage repair network that is strongly implicated in both survival and acquired drug resistance under antimicrobial stress. The two SOS regulators, LexA and RecA, have therefore emerged as potential target
Externí odkaz:
https://doaj.org/article/cd434ad32ed346dbba391515d322b75a
Autor:
Edwin Chen, Matthew J. Culyba
Publikováno v:
Structure (London, England : 1993). 30(11)
In this issue of Structure, Maso et al. (2022) discover nanobodies that inhibit the SOS response of Escherichia coli by targeting the LexA repressor-protease. High-resolution structures of the novel LexA-nanobody complexes reveal they function by sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9006366e240b74e052c87e2b703baff4
https://pubmed.ncbi.nlm.nih.gov/36240773
https://pubmed.ncbi.nlm.nih.gov/36240773
Autor:
Mitra M. Elgrail, Edwin Chen, Marla G. Shaffer, Vatsala Srinivasa, Marissa P. Griffith, Mustapha M. Mustapha, Ryan K. Shields, Daria Van Tyne, Matthew J. Culyba
Publikováno v:
Infection and Immunity. 90
Severe infections caused by methicillin-resistant Staphylococcus aureus (MRSA) are often complicated by persistent bacteremia (PB) despite active antibiotic therapy. Antibiotic resistance rarely contributes to MRSA-PB, suggesting an important role fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6b5cacde2e57fcba8b5b31bd5650674
https://doi.org/10.1128/iai.00001-22
https://doi.org/10.1128/iai.00001-22
Autor:
Daria Van Tyne, Matthew J. Culyba
Publikováno v:
PLoS Pathogens, Vol 17, Iss 9, p e1009872 (2021)
PLoS Pathogens
PLoS Pathogens
Microbes are constantly evolving. Laboratory studies of bacterial evolution increase our understanding of evolutionary dynamics, identify adaptive changes, and answer important questions that impact human health. During bacterial infections in humans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cbdc727859ac5592da063d2ca8a97f8
https://doaj.org/article/076d81a401874d6293090fb02bdbe382
https://doaj.org/article/076d81a401874d6293090fb02bdbe382
Publikováno v:
G3 (Bethesda, Md.). 12(2)
The bacterial DNA damage response pathway (SOS response) is composed of a network of genes regulated by a single transcriptional repressor, LexA. The lexA promoter, itself, contains two LexA operators, enabling negative feedback. In Escherichia coli,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5464b2892229aa6f616b2be5e1cfbcfb
https://pubmed.ncbi.nlm.nih.gov/34849799
https://pubmed.ncbi.nlm.nih.gov/34849799
Publikováno v:
DNA Repair (Amst)
The bacterial SOS response to DNA damage induces an error-prone repair program that is mutagenic. In Escherichia coli, SOS-induced mutations are caused by the translesion synthesis (TLS) activity of two error-prone polymerases (EPPs), Pol IV and Pol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6402a0dd2cf68cffaaf6e76e28398fd3
https://pubmed.ncbi.nlm.nih.gov/33991871
https://pubmed.ncbi.nlm.nih.gov/33991871
Publikováno v:
Open Forum Infectious Diseases. 8:S78-S79
Background Persistent MRSA bacteremia is common with high morbidity and mortality despite appropriate antibiotics. Persistent infections are associated with antibiotic tolerance and can arise from perturbations in cellular pathways. We performed whol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4eaeb5a4e0db34ca7ac9ec0d5598ed9d
https://doi.org/10.1093/ofid/ofab466.128
https://doi.org/10.1093/ofid/ofab466.128