Výsledky vyhledávání - "Matthew J. Cotter"

Data from Anti-inflammatory Triterpenoid Blocks Immune Suppressive Function of MDSCs and Improves Immune Response in Cancer

Autor: Dmitry I. Gabrilovich, Ji-Hyun Lee, Bhupendra Rawal, Karen T. Liby, Michael B. Sporn, Scott Antonia, Mayer Fishman, Carlos R. Becerra, Colin Meyer, Matthew J. Cotter, Lily Lu, Cristina Iclozan, Hannah Weber, Je-In Youn, Srinivas Nagaraj

Purpose: Myeloid-derived suppressor cells (MDSC) are one of the major factors responsible for immune suppression in cancer. Therefore, it would be important to identify effective therapeutic means to modulate these cells.Experimental Design: We evalu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::754fcf863b7be5a65ae611d96ca7c4a6
https://doi.org/10.1158/1078-0432.c.6519602.v1

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A Phase I trial of talazoparib in patients with advanced hematologic malignancies

Autor: Ajay K, Gopal, Rakesh, Popat, Ryan J, Mattison, Tobias, Menne, Adrian, Bloor, Terry, Gaymes, Asim, Khwaja, Mark, Juckett, Ying, Chen, Matthew J, Cotter, Ghulam J, Mufti

Publikováno v: International Journal of Hematologic Oncology

Aim: The objective of this study was to establish the maximum tolerated dose (MTD), safety, pharmacokinetics, and anti-leukemic activity of talazoparib. Patients & methods: This Phase I, two-cohort, dose-escalation trial evaluated talazoparib monothe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7732526f9cc4b1831e79ba284cf9cdac
https://pubmed.ncbi.nlm.nih.gov/34840720

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Concordance of real-world versus conventional progression-free survival from a phase 3 trial of endocrine therapy as first-line treatment for metastatic breast cancer

Autor: Ariel B. Bourla, Zhe Zhang, Cynthia Huang Bartlett, Christina M. Parrinello, Jack Mardekian, Xin Huang, Matthew J. Cotter

Publikováno v: PLoS ONE, Vol 15, Iss 4, p e0227256 (2020)
PLoS ONE

There is growing interest in leveraging real-world data to complement knowledge gained from randomized clinical trials and inform the design of prospective randomized studies in oncology. The present study compared clinical outcomes in women with met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8266ee68478c8645d2808146ce79eec4
https://doaj.org/article/4e74ebefa98140199420adc1c7d5e62e

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Abstract P5-21-24: Retrospective assessment of treatment patterns and outcomes associated with palbociclib plus letrozole for postmenopausal women with HR+/HER2– advanced breast cancer enrolled in an early access program

Autor: Keith L. Davis, S Nagar, Vered Stearns, Lynn McRoy, Matthew J. Cotter, Adam Brufsky, Debanjali Mitra

Publikováno v: Cancer Research. 78:P5-21

Background: The objective of this study was to evaluate treatment patterns and clinical outcomes among patients who received palbociclib in combination with letrozole (P+L) for the treatment of HR+/HER2–advanced breast cancer (ABC) as part of an Ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fb5efddb48e286382cbd6b695ea50493
https://doi.org/10.1158/1538-7445.sabcs17-p5-21-24

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Abstract P3-17-03: Concordance of real world progression free survival (PFS) on endocrine therapy as first line treatment for metastatic breast cancer using electronic health record with proper quality control versus conventional PFS from a phase 3 trial

Autor: AP Abernethy, Zhe Zhang, M Koehler, Xin-Yun Huang, Jack Mardekian, CM Parrinello, Cynthia Huang Bartlett, Matthew J. Cotter

Publikováno v: Cancer Research. 78:P3-17

Background: There is growing interest to assess treatment effect with clinical endpoints that are reflective of real world clinical practice based on data systemically collected from the electronic health record (EHR). This study compared real world

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::243405c3ec640a6404a0cb7f530dcffd
https://doi.org/10.1158/1538-7445.sabcs17-p3-17-03

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Treatment Patterns and Outcomes Associated With Palbociclib Plus Letrozole for Postmenopausal Women With HR

Autor: Adam, Brufsky, Debanjali, Mitra, Keith L, Davis, Saurabh P, Nagar, Lynn, McRoy, Matthew J, Cotter, Vered, Stearns

Publikováno v: Clinical breast cancer. 19(5)

To evaluate treatment patterns and clinical outcomes of patients who received palbociclib in combination with letrozole in any line of therapy for treatment of hormone receptor-positive, human epidermal growth factor receptor 2-negative metastatic br

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8cea4c279f808389d0e30b8725c60417
https://pubmed.ncbi.nlm.nih.gov/31104984

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Treatment Patterns and Outcomes Associated With Palbociclib Plus Letrozole for Postmenopausal Women With HR+/HER2− Advanced Breast Cancer Enrolled in an Expanded Access Program

Autor: Vered Stearns, Debanjali Mitra, Matthew J. Cotter, Adam Brufsky, Keith L. Davis, Lynn McRoy, Saurabh P Nagar

Publikováno v: Clinical Breast Cancer. 19:317-325.e4

Purpose To evaluate treatment patterns and clinical outcomes of patients who received palbociclib in combination with letrozole in any line of therapy for treatment of hormone receptor–positive, human epidermal growth factor receptor 2–negative m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f5aa06549079d94224374271a9f73727
https://doi.org/10.1016/j.clbc.2019.04.005

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Combination of External Beam Radiotherapy (EBRT) With Intratumoral Injection of Dendritic Cells as Neo-Adjuvant Treatment of High-Risk Soft Tissue Sarcoma Patients

Autor: David Cheong, G. Douglas Letson, Brianna Lenox, Cristina Iclozan, Ricardo J. Gonzalez, Claudia Berman, Steven E. Finkelstein, Rupal Ramakrishnan, Scott J. Antonia, Vernon K. Sondak, David Noyes, Jamil Ahmed, William J. Janssen, Dmitry I. Gabrilovich, Jonathan S. Zager, Randy V. Heysek, Marilyn M. Bui, Matthew J. Cotter

Publikováno v: International Journal of Radiation Oncology*Biology*Physics. 82:924-932

Purpose The goal of this study was to determine the effect of combination of intratumoral administration of dendritic cells (DC) and fractionated external beam radiation (EBRT) on tumor-specific immune responses in patients with soft-tissue sarcoma (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9477a6f2764d5469d8a264bb279e8ee0
https://doi.org/10.1016/j.ijrobp.2010.12.068

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