Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Matthew J. Burak"'
Autor:
Tania Rahim, R. Stephen Lloyd, Joann B. Sweasy, Melis Kant, Alireza G. Senejani, Madison Levinson, Stephen E. Maher, Miral Dizdaroglu, Caroline J. Zeiss, Rithy Meas, Marina Cardó-Vila, Sesha L. A. Paluri, Kaylyn Clairmont, Michael Kashgarian, Isabel Alvarado-Cruz, Pawel Jaruga, Alfred L. M. Bothwell, Erdem Coskun, Matthew J. Burak
Publikováno v:
DNA Repair (Amst)
The Polb gene encodes DNA polymerase beta (Pol β), a DNA polymerase that functions in base excision repair (BER) and microhomology-mediated end-joining. The Pol β-Y265C protein exhibits low catalytic activity and fidelity, and is also deficient in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4ed4da1a3471381db99c441029e0b4f
https://pubmed.ncbi.nlm.nih.gov/34186496
https://pubmed.ncbi.nlm.nih.gov/34186496
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with no known cure that affects at least five million people worldwide. Monozygotic twin concordance and familial aggregation studies strongly suggest that lupus results from genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c253294c874841ed5a55e414f2094402
https://europepmc.org/articles/PMC5543809/
https://europepmc.org/articles/PMC5543809/
Publikováno v:
The EMBO journal. 35(18)
8-oxo-7,8-dihydroxy-2'-deoxyguanosine (8-oxo-dG) has high mutagenic potential as it is prone to mispair with deoxyadenine (dA). In order to maintain genomic integrity, post-replicative 8-oxo-dG:dA mispairs are removed through DNA polymerase lambda (P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e9c24c1793b79f9aeecba32bc85916e
https://pubmed.ncbi.nlm.nih.gov/27481934
https://pubmed.ncbi.nlm.nih.gov/27481934
Publikováno v:
Nucleic Acids Research
8-Oxo-7,8,-dihydro-2'-deoxyguanosine triphosphate (8-oxo-dGTP) is a major product of oxidative damage in the nucleotide pool. It is capable of mispairing with adenosine (dA), resulting in futile, mutagenic cycles of base excision repair. Therefore, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bdc1b47c0c6ec7c56c820ebf036fb40
https://pubmed.ncbi.nlm.nih.gov/26220180
https://pubmed.ncbi.nlm.nih.gov/26220180
Autor:
Edison Mejia, Thomas A. Kunkel, Matthew J. Burak, Katarzyna Bebenek, Miguel Garcia-Diaz, Ana Alonso, Vicente Larraga
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
9 p.-4 fig.-4 tab.
Protozoans of the genus Leishmania, the pathogenic agent causing leishmaniasis, encode the family X DNA polymerase Li Pol β. Here, we report the first crystal structures of Li Pol β. Our pre- and post-catalytic structures sh
Protozoans of the genus Leishmania, the pathogenic agent causing leishmaniasis, encode the family X DNA polymerase Li Pol β. Here, we report the first crystal structures of Li Pol β. Our pre- and post-catalytic structures sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::703671977cd002edb052cddcb046c36d
http://hdl.handle.net/10261/211745
http://hdl.handle.net/10261/211745