A multi-pathway exposure assessment for polycyclic aromatic hydrocarbons among residents in the Athabasca oil sands region, Canada

Autor: Faqiang Zhan, Abha Parajulee, Matthew J. Binnington, Anya Gawor, Frank Wania

Publikováno v: Environmental Science: Processes & Impacts. 25:755-766

The dietary intake of PAHs with traditional food, estimated with a mechanistic food chain bioaccumulation model, is compared with the exposure arising from ingesting market food and smoking cigarettes.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c3061966b7cf6a9221d21de0ee9e5a71
https://doi.org/10.1039/d2em00526c

Mechanistic modeling of persistent organic pollutant exposure among indigenous Arctic populations: motivations, challenges, and benefits

Autor: Frank Wania, Matthew J. Binnington, Meredith S. Curren

Publikováno v: Environmental Reviews. 25:396-407

Indigenous Arctic populations experience elevated exposures to many environmental contaminants compared with groups residing in southern Canada. This is largely due to consumption of traditional foods, some of which (ringed seals, beluga whales, narw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::12ec65dcd3e53c9e7bf46c11e4294ffb
https://doi.org/10.1139/er-2017-0010

Mechanistic polychlorinated biphenyl exposure modeling of mothers in the Canadian Arctic: the challenge of reliably establishing dietary composition

Autor: Frank Wania, James M. Armitage, Jon A. Arnot, Cristina L. Quinn, Meredith S. Curren, Hing Man Chan, Matthew J. Binnington

Publikováno v: Environment International, Vol 92, Iss, Pp 256-268 (2016)

Background: Traditional food (TF) consumption represents the main route of persistent organic pollutant (POP) exposure for indigenous Arctic Canadians. Ongoing dietary transitions away from TFs and toward imported foods (IFs) may contribute to decrea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb0d24f8fd7d7a2eb460bd7eacccef0b
https://doi.org/10.1016/j.envint.2016.04.011

Effects of preparation on nutrient and environmental contaminant levels in Arctic beluga whale (Delphinapterus leucas) traditional foods

Autor: Ying Duan Lei, Lisa L. Loseto, Hing Man Chan, Frank Wania, Leo W. Y. Yeung, James Pokiak, Lucky Pokiak, Matthew J. Binnington, Sonja K. Ostertag, Haiyong Huang

Publikováno v: Environmental science. Processesimpacts. 19(8)

For Canadian Arctic indigenous populations, marine mammal (MM) traditional foods (TFs) represent sources of both important nutrients and hazardous environmental contaminants. Food preparation is known to impact the nutrient and environmental contamin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7169b5527985f526041d1abde430f9e5
https://pubmed.ncbi.nlm.nih.gov/28752885

Alaska Native smokers and smokeless tobacco users with slower CYP2A6 activity have lower tobacco consumption, lower tobacco-specific nitrosamine exposure and lower tobacco-specific nitrosamine bioactivation

Autor: Neal L. Benowitz, Clifford H. Watson, Connie S. Sosnoff, Dorothy K. Hatsukami, Irina Stepanov, Matthew J. Binnington, Anne P. Lanier, Caroline C. Renner, Andy Z. X. Zhu, Rachel F. Tyndale

Publikováno v: Zhu, AZX; Binnington, MJ; Renner, CC; Lanier, AP; Hatsukami, DK; Stepanov, I; et al.(2013). Alaska native smokers and smokeless tobacco users with slower CYP2A6 activity have lower tobacco consumption, lower tobacco-specific nitrosamine exposure and lower tobacco-specific nitrosamine bioactivation. Carcinogenesis, 34(1), 93-101. doi: 10.1093/carcin/bgs306. UCSF: Retrieved from: http://www.escholarship.org/uc/item/4f29x41t

Nicotine, the psychoactive ingredient in tobacco, is metabolically inactivated by CYP2A6 to cotinine. CYP2A6 also activates procarcinogenic tobacco-specific nitrosamines (TSNA). Genetic variation in CYP2A6 is known to alter smoking quantity and lung

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f93bf7be13feef92ab23b8279c2cfe34
https://doi.org/10.1093/carcin/bgs306