Výsledky vyhledávání - "Matthew J Stroud"

Akademický článek

Muscle fibre size and myonuclear positioning in trained and aged humans

Autor: Edmund Battey, Yotam Levy, Ross D. Pollock, Jamie N. Pugh, Graeme L. Close, Michaeljohn Kalakoutis, Norman R. Lazarus, Stephen D. R. Harridge, Julien Ochala, Matthew J. Stroud

Publikováno v: Experimental Physiology, Vol 109, Iss 4, Pp 549-561 (2024)

Abstract Changes in myonuclear architecture and positioning are associated with exercise adaptations and ageing. However, data on the positioning and number of myonuclei following exercise are inconsistent. Additionally, whether myonuclear domains (M

Externí odkaz: https://doaj.org/article/a3668283bcbf463f972b941b5d8f8d8b

Zobrazit plný text záznamu

Lem2 is essential for cardiac development by maintaining nuclear integrity

Autor: Jacob A Ross, Nathaly Arcos-Villacis, Edmund Battey, Cornelis Boogerd, Constanza Avalos Orellana, Emilie Marhuenda, Pamela Swiatlowska, Didier Hodzic, Fabrice Prin, Tim Mohun, Norman Catibog, Olga Tapia, Larry Gerace, Thomas Iskratsch, Ajay M Shah, Matthew J Stroud

Publikováno v: Cardiovascular Research.

Aims Nuclear envelope integrity is essential for the compartmentalization of the nucleus and cytoplasm. Importantly, mutations in genes encoding nuclear envelope (NE) and associated proteins are the second highest cause of familial dilated cardiomyop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1fb8b340c57ca8940e08444cacc4c7fc
https://doi.org/10.1093/cvr/cvad061

Zobrazit plný text záznamu

Using nuclear envelope mutations to explore age-related skeletal muscle weakness

Autor: Julien Ochala, Edmund Battey, Matthew J. Stroud

Publikováno v: Clinical Science (London, England : 1979)
Battey, E, Stroud, M J & Ochala, J 2020, ' Using nuclear envelope mutations to explore age-related skeletal muscle weakness ', Clinical Science, vol. 134, no. 16, pp. 2177-2187 . https://doi.org/10.1042/CS20190066

Skeletal muscle weakness is an important determinant of age-related declines in independence and quality of life but its causes remain unclear. Accelerated ageing syndromes such as Hutchinson–Gilford Progerin Syndrome, caused by mutations in genes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f90c23ff89b0c60aa9dc13305c49852b
http://europepmc.org/articles/PMC7450176

Zobrazit plný text záznamu

Lem2 is essential for cardiac development by maintaining nuclear integrity

Autor: Jacob A. Ross, Nathaly Arcos-Villacis, Edmund Battey, Cornelis Boogerd, Emilie Marhuenda, Didier Hodzic, Fabrice Prin, Tim Mohun, Norman Catibog, Olga Tapia, Larry Gerace, Thomas Iskratsch, Ajay M. Shah, Matthew J. Stroud

Nuclear envelope integrity is essential for compartmentalisation of nucleus and cytoplasm. Importantly, mutations in nuclear envelope-encoding genes are the second-highest cause of familial dilated cardiomyopathy. One such nuclear envelope protein th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::57e8452b95430984c42e6951272e2bd8
https://doi.org/10.1101/2022.02.10.477501

Zobrazit plný text záznamu

Akademický článek

Targeted ablation of nesprin 1 and nesprin 2 from murine myocardium results in cardiomyopathy, altered nuclear morphology and inhibition of the biomechanical gene response.

Autor: Indroneal Banerjee, Jianlin Zhang, Thomas Moore-Morris, Emily Pfeiffer, Kyle S Buchholz, Ao Liu, Kunfu Ouyang, Matthew J Stroud, Larry Gerace, Sylvia M Evans, Andrew McCulloch, Ju Chen

Publikováno v: PLoS Genetics, Vol 10, Iss 2, p e1004114 (2014)

Recent interest has focused on the importance of the nucleus and associated nucleoskeleton in regulating changes in cardiac gene expression in response to biomechanical load. Mutations in genes encoding proteins of the inner nuclear membrane and nucl

Externí odkaz: https://doaj.org/article/0ffa33f0b87146718f10ed4b4565896e

Zobrazit plný text záznamu

PGC-1α regulates myonuclear accretion after moderate endurance training

Autor: Regula Furrer, Christoph Handschin, Julien Ochala, Edmund Battey, Jacob A. Ross, Matthew J. Stroud

Publikováno v: Battey, E, Furrer, R, Ross, J, Handschin, C, Ochala, J & Stroud, M J 2022, ' PGC-1α regulates myonuclear accretion after moderate endurance training ', Journal of Cellular Physiology, vol. 237, no. 1, pp. 696-705 . https://doi.org/10.1002/jcp.30539

The transcriptional demands of skeletal muscle fibres are high and require hundreds of nuclei (myonuclei) to produce specialised contractile machinery and multiple mitochondria along their length. Each myonucleus spatially regulates gene expression i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76d0785b0105eb47fc24fbb19d57b2ad
https://edoc.unibas.ch/84238/

Zobrazit plný text záznamu

Linker of nucleoskeleton and cytoskeleton complex proteins in cardiomyopathy

Autor: Matthew J. Stroud

Publikováno v: Stroud, M 2018, ' Linker of nucleoskeleton and cytoskeleton complex proteins in cardiomyopathy ', Biophysical Reviews, pp. 1-19 . https://doi.org/10.1007/s12551-018-0431-6
Biophysical Reviews

The linker of nucleoskeleton and cytoskeleton (LINC) complex couples the nuclear lamina to the cytoskeleton. The LINC complex and its associated proteins play diverse roles in cells, ranging from genome organization, nuclear morphology, gene expressi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0a3841e853e93edee96f92dd7008fa7
https://doi.org/10.1007/s12551-018-0431-6

Zobrazit plný text záznamu

Luma is not essential for murine cardiac development and function

Autor: Kirk L. Peterson, Yusu Gu, Xi Fang, Matthew J. Stroud, William H. Bradford, Larry Gerace, Nuno Guimarães-Camboa, Sylvia M. Evans, Nancy D. Dalton, Ju Chen, Jianlin Zhang, Jennifer Veevers

Publikováno v: Stroud, M J, Fang, X, Zhang, J, Guimaraes-Camboa, N, Veevers, J, Dalton, N D, Gu, Y, Bradford, W H, Peterson, K L, Evans, S M, Gerace, L & Chen, J 2018, ' Luma is not essential for murine cardiac development and function ', Cardiovascular Research, vol. 114, no. 3, pp. 378-388 . https://doi.org/10.1093/cvr/cvx205

AimsLuma is a recently discovered, evolutionarily conserved protein expressed in mammalian heart, which is associated with the LInker of Nucleoskeleton and Cytoskeleton (LINC) complex. The LINC complex structurally integrates the nucleus and the cyto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06d20eebd07ad7e81236802d474f827b
https://doi.org/10.1093/cvr/cvx205

Zobrazit plný text záznamu

Nesprin 1α2 is essential for mouse postnatal viability and nuclear positioning in skeletal muscle

Autor: Wei Feng, Xi Fang, Jennifer Veevers, Ju Chen, Jianlin Zhang, Larry Gerace, Matthew J. Stroud

Publikováno v: The Journal of Cell Biology
The Journal of cell biology, vol 216, iss 7

Defects in nuclear positioning occur in muscle diseases and correlate with muscle dysfunction. In this study, Stroud et al. show that nesprin 1α2 is the fundamental nesprin 1 isoform for nuclear positioning, skeletal muscle function, and postnatal v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c5986211fc37f062e05bad1c0e1c50d
https://doi.org/10.1083/jcb.201612128

Zobrazit plný text záznamu

Generation and Analysis of Striated Muscle Selective LINC Complex Protein Mutant Mice

Autor: Xi Fang, Ju Chen, Jennifer Veevers, Matthew J. Stroud

Publikováno v: The LINC Complex ISBN: 9781493986903

The linker of nucleoskeleton and cytoskeleton (LINC) complex mediates intracellular cross talk between the nucleus and the cytoplasm. In striated muscle, the LINC complex provides structural support to the myocyte nucleus and plays an essential role

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb2458aaa99fcfa3b57d3fa3af2c1538
https://pubmed.ncbi.nlm.nih.gov/30141050

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání