Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Matthew J Rieser"'
Autor:
Thomas W von Geldern, Howard E Morton, Rick F Clark, Brian S Brown, Kelly L Johnston, Louise Ford, Sabine Specht, Robert A Carr, Deanne F Stolarik, Junli Ma, Matthew J Rieser, Dominique Struever, Stefan J Frohberger, Marianne Koschel, Alexandra Ehrens, Joseph D Turner, Marc P Hübner, Achim Hoerauf, Mark J Taylor, Stephen A Ward, Kennan Marsh, Dale J Kempf
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 13, Iss 2, p e0007159 (2019)
There is a significant need for improved treatments for onchocerciasis and lymphatic filariasis, diseases caused by filarial worm infection. In particular, an agent able to selectively kill adult worms (macrofilaricide) would be expected to substanti
Externí odkaz:
https://doaj.org/article/68bed1add1a349b9b6bff6345f18be14
Publikováno v:
CardioVascular and Interventional Radiology. 37:218-223
The recent success of renal denervation in lowering blood pressure in drug-resistant hypertensive patients has stimulated interest in developing novel approaches to renal denervation including local drug/chemical delivery. The purpose of this study w
Autor:
Gerard J. Marek, Walid M. Awni, Wei Liu, Dan Daszkowski, Charles Locke, Yi Wang, Matthew J. Rieser, David A. Katz, Sandeep Dutta
Publikováno v:
Clinical Pharmacology in Drug Development. 2:133-151
ABT-384 is a potent and selective inhibitor of 11β-hydroxysteroid dehydrogenase type 1 (HSD-1), the enzyme that regenerates cortisol in several tissues. Two clinical studies of ABT-384 were undertaken to assess its safety, pharmacokinetics, target e
Publikováno v:
Pharmaceutics, Vol 2, Iss 2, Pp 171-181 (2010)
Pharmaceutics
Volume 2
Issue 2
Pages 171-181
Pharmaceutics
Volume 2
Issue 2
Pages 171-181
A fully automated 96-well On-Line Solid Phase Extraction (SPE) followed by High Performance Liquid Chromatography (HPLC)-Tandem Mass Spectrometric (MS/MS) method for the determination of ABT-925 (2-{3-[4-(2-tert-Butyl-6-trifluoromethyl-pyrimidin-4-yl
Autor:
Maria P Metchkarova, Michelle Kranz, Matthew J. Rieser, Phillip Vaca, Jill E. Polzin, Tawakol A. El-Shourbagy, Raymond Naxing Xu
Publikováno v:
Pharmaceutics, Vol 2, Iss 2, Pp 159-170 (2010)
Pharmaceutics
Volume 2
Issue 2
Pages 159-170
Pharmaceutics
Volume 2
Issue 2
Pages 159-170
When compared with biological samples in other matrices (plasma, urine, etc.) that are typically seen in bioanalytical applications, whole blood samples present unique challenges in method development, because of the viscous nature of blood and compl
Publikováno v:
Journal of Chromatographic Science. 47:473-477
Monolithic columns have been used in recent years for fast chromatographic separation due to their high permeability and low backpressure. We have explored the potential of monolithic material as sample preparation tool in bioanalytical applications.
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 44:342-355
Liquid chromatography linked to tandem mass spectrometry (LC-MS/MS) has played an important role in pharmacokinetics and metabolism studies at various drug development stages since its introduction to the pharmaceutical industry. This article reviews
Autor:
Lawrence Galitz, Laura A. Williams, Jenny Chan, Rajendra S. Pradhan, Rameshraja Palaparthy, Titus Chira, Matthew J. Rieser, Walid M. Awni
Publikováno v:
Biopharmaceutics & Drug Disposition. 28:65-71
Paricalcitol capsules are indicated for the prevention and treatment of secondary hyperparathyroidism in chronic kidney disease (CKD). Proton pump inhibitors are prescribed to CKD patients to treat gastroesophageal reflux. This was a single dose, cro
Autor:
Maureen T. Kelly, Ramanuj Achari, H. Daniel Yannicelli, David A. Burt, Timi Edeki, Sarah M. Schweitzer, Linda E. Gustavson, Titus Chira, Matthew J. Rieser
Publikováno v:
Clinical Therapeutics. 28:373-387
This study was conducted to evaluate the potential for pharmacokinetic interaction between fenofibrate and ezetimibe in healthy subjects.This was a Phase I, open-label, multiple-dose,3-period crossover study conducted in healthy adult men and women.
Publikováno v:
Journal of Natural Products. 59:100-108
Bioactivity-directed fractionation of the seeds of Annona muricata L. (Annonaceae) resulted in the isolation of five new compounds: cis-annonacin (1), cis-annonacin-10-one (2), cis-goniothalamicin (3), arianacin (4), and javoricin (5). Three of these