Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Matthew J Meiners"'
Autor:
Matthew R Marunde, Harrison A Fuchs, Jonathan M Burg, Irina K Popova, Anup Vaidya, Nathan W Hall, Ellen N Weinzapfel, Matthew J Meiners, Rachel Watson, Zachary B Gillespie, Hailey F Taylor, Laylo Mukhsinova, Ugochi C Onuoha, Sarah A Howard, Katherine Novitzky, Eileen T McAnarney, Krzysztof Krajewski, Martis W Cowles, Marcus A Cheek, Zu-Wen Sun, Bryan J Venters, Michael-C Keogh, Catherine A Musselman
Publikováno v:
eLife, Vol 13 (2024)
Histone post-translational modifications (PTMs) play a critical role in chromatin regulation. It has been proposed that these PTMs form localized ‘codes’ that are read by specialized regions (reader domains) in chromatin-associated proteins (CAPs
Externí odkaz:
https://doaj.org/article/bb8066ecda624cd69e4af12da10f5a2d
Autor:
Kanishk Jain, Matthew R Marunde, Jonathan M Burg, Susan L Gloor, Faith M Joseph, Karl F Poncha, Zachary B Gillespie, Keli L Rodriguez, Irina K Popova, Nathan W Hall, Anup Vaidya, Sarah A Howard, Hailey F Taylor, Laylo Mukhsinova, Ugochi C Onuoha, Emily F Patteson, Spencer W Cooke, Bethany C Taylor, Ellen N Weinzapfel, Marcus A Cheek, Matthew J Meiners, Geoffrey C Fox, Kevin EW Namitz, Martis W Cowles, Krzysztof Krajewski, Zu-Wen Sun, Michael S Cosgrove, Nicolas L Young, Michael-Christopher Keogh, Brian D Strahl
Publikováno v:
eLife, Vol 12 (2023)
In nucleosomes, histone N-terminal tails exist in dynamic equilibrium between free/accessible and collapsed/DNA-bound states. The latter state is expected to impact histone N-termini availability to the epigenetic machinery. Notably, H3 tail acetylat
Externí odkaz:
https://doaj.org/article/4578fc571e78426c9ad347f2e09aa9c9
Autor:
Jonathan F. Thomas, Marco Igor Valencia-Sánchez, Simone Tamburri, Susan L. Gloor, Samantha Rustichelli, Victoria Godínez-López, Pablo De Ioannes, Rachel Lee, Stephen Abini-Agbomson, Kristjan Gretarsson, Jonathan M. Burg, Allison R. Hickman, Lu Sun, Saarang Gopinath, Hailey Taylor, Matthew J. Meiners, Marcus A. Cheek, William Rice, Evgeny Nudler, Chao Lu, Michael-Christopher Keogh, Diego Pasini, Karim-Jean Armache
Publikováno v:
bioRxiv
The maintenance of gene expression patterns during metazoan development is achieved by the actions of Polycomb group (PcG) complexes. An essential modification marking silenced genes is monoubiquitination of histone H2A lysine 119 (H2AK119Ub) deposit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7db25e4b2a5a80a0e97a9d5d66c694d3
https://doi.org/10.1101/2023.02.23.529554
https://doi.org/10.1101/2023.02.23.529554
Autor:
Marcus A. Cheek, Aiping Dong, Renato Ferreira de Freitas, Dalia Barsyte-Lovejoy, Aliakbar Khalili Yazdi, Jinrong Min, Fengling Li, Victoria Vu, Albina Bolotokova, Lindsey I. James, Jack Greenblatt, Naimee Mehta, Irina K. Popova, David Dilworth, Ming Lei, Raquel Arminda Carvalho Machado, Ronan P Hanley, David Y Nie, Matthieu Schapira, Mengqi Zhou, Elisa Gibson, Cheryl H. Arrowsmith, Michael-Christopher Keogh, Suzanne Ackloo, Matthew R. Marunde, Mona Alqazzaz, Dmitri Kireev, Nathan W. Hall, Peter Brown, Abdellah Allali-Hassani, Sina Kazemzadeh, Edyta Marcon, Tigran M. Abramyan, Dominic D G Owens, Yanli Liu, Magdalena M. Szewczyk, Matthew J. Meiners, Irene Chau, Su Qin, Masoud Vedadi
Publikováno v:
Nat Chem Biol
Nuclear receptor-binding SET domain-containing 2 (NSD2) is the primary enzyme responsible for the dimethylation of lysine 36 of histone 3 (H3K36), a mark associated with active gene transcription and intergenic DNA methylation. In addition to a methy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a29b52d0f1e30e6d3bd73de3c2a5989b
https://doi.org/10.1038/s41589-021-00898-0
https://doi.org/10.1038/s41589-021-00898-0
Autor:
Zachary B. Gillespie, Neil L. Kelleher, Jonathan D. Licht, Marcus A. Cheek, Amin Sobh, Sarah A. Howard, Michael-Christopher Keogh, Luis F. Schachner, Kevin Jooß, Matthew J. Meiners, Rachel Watson
Publikováno v:
Anal Chem
We report a novel platform [native capillary zone electrophoresis–top-down mass spectrometry (nCZE–TDMS)] for the separation and characterization of whole nucleosomes, their histone subunits, and post-translational modifications (PTMs). As the re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ac31269a410e4f0c34ce0d226a6478e
https://doi.org/10.1021/acs.analchem.0c04975
https://doi.org/10.1021/acs.analchem.0c04975
Autor:
Lu Sun, Hannah Willis, Matthew R. Marunde, Vishnu U. Kumary, Matthew J. Meiners, Saarang Gopinath, Jonathan M. Burg, Bryan J. Venters, Allison Hickman, Zu-Wen Sun, Martis W. Cowles, Pierre Esteve, Hang Gyeong Chin, Chaithanya Ponnaluri, Sriharsa Pradhan, Michael-Christopher Keogh
Publikováno v:
Cancer Research. 83:4728-4728
Chromatin remodeling is mediated by ATP-dependent enzymes that play key roles regulating gene expression and genome replication/repair. Aberrant nucleosome organization from dysregulated chromatin remodeling can severely alter chromatin accessibility
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea34cab5bb0c8f6e2385230ae125ff9d
https://doi.org/10.1158/1538-7445.am2023-4728
https://doi.org/10.1158/1538-7445.am2023-4728
Autor:
Håkan Wallén, Andrea L. Johnstone, Saira Z Sheikh, Denis F. Noubouossie, Katherina Aguilera, Maja Månsson, Matthew R. Marunde, Charlotte Thålin, Matthew J. Meiners, Sarah A. Howard, Maud Daleskog, Martis W. Cowles, Zu-Wen Sun, Staffan Lundström, Jonathan M. Burg, Michael-Christopher Keogh, Axel Rosell, Nathan W. Hall, Marcus A. Cheek, Matthew F. Whelihan, Yohei Hisada, Nigel Mackman, Nigel S. Key, Shruti Saxena-Beem
Publikováno v:
Journal of thrombosis and haemostasis : JTH
Background Recent data propose a diagnostic and prognostic capacity for citrullinated histone H3 (H3Cit), a marker of neutrophil extracellular traps (NETs), in pathologic conditions such as cancer and thrombosis. However, current research is hampered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ae90fd748dbb220c9c7c6d7ca84b038
https://doi.org/10.1111/jth.15003
https://doi.org/10.1111/jth.15003
Autor:
Kanishk Jain, Matthew R Marunde, Jonathan M Burg, Susan L Gloor, Faith M Joseph, Karl F Poncha, Zachary B Gillespie, Keli L Rodriguez, Irina K Popova, Nathan W Hall, Anup Vaidya, Sarah A Howard, Hailey F Taylor, Laylo Mukhsinova, Ugochi C Onuoha, Emily F Patteson, Spencer W Cooke, Bethany C Taylor, Ellen N Weinzapfel, Marcus A Cheek, Matthew J Meiners, Geoffrey C Fox, Kevin EW Namitz, Martis W Cowles, Krzysztof Krajewski, Zu-Wen Sun, Michael S Cosgrove, Nicolas Young, Michael-C Keogh, Brian D Strahl
In nucleosomes, histone N-terminal tails exist in dynamic equilibrium between free/accessible and collapsed/DNA-bound states. The latter state is expected to impact histone N-termini availability to the epigenetic machinery. Notably, H3 tail acetylat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56293051dfd39cb6a2645e19d0fa20ad
https://doi.org/10.1101/2022.02.28.482307
https://doi.org/10.1101/2022.02.28.482307
Autor:
Matthew R. Marunde, Harrison A. Fuchs, Jonathan M. Burg, Irina K. Popova, Anup Vaidya, Nathan W. Hall, Matthew J. Meiners, Rachel Watson, Sarah A. Howard, Katherine Novitzky, Eileen McAnarney, Marcus A. Cheek, Zu-Wen Sun, Bryan J. Venters, Michael-C. Keogh, Catherine A. Musselman
Histone post-translational modifications (PTMs) play a critical role in chromatin regulation. It has been proposed that these PTMs form localized ‘codes’ that are read by specialized regions (reader domains) in chromatin associated proteins (CAPs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cadb227370ba71c1b1a82a94875c1c85
https://doi.org/10.1101/2022.02.21.481373
https://doi.org/10.1101/2022.02.21.481373
Autor:
Emily J. Rendleman, Scott B. Rothbart, Robert M. Vaughan, Irina K. Popova, Michael-Christopher Keogh, Anup Vaidya, Sarah A. Howard, Zachary J. Dumar, Matthew J. Meiners, Ali Shilatifard, Marc A. Morgan, Rachel Watson, Jonathan M. Burg, Natalia Khalatyan, Matthew R. Marunde
Publikováno v:
Genesdevelopment. 35(23-24)
Mutations in thePHIP/BRWD2chromatin regulator cause the human neurodevelopmental disorder Chung-Jansen syndrome, while alterations inPHIPexpression are linked to cancer. Precisely how PHIP functions in these contexts is not fully understood. Here we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0207d49d90af5e74f114943e6870eecb
https://pubmed.ncbi.nlm.nih.gov/34819353
https://pubmed.ncbi.nlm.nih.gov/34819353