Zobrazeno 1 - 10
of 136
pro vyhledávání: '"Matthew J Lang"'
Publikováno v:
eLife, Vol 13 (2024)
Mechanical force is critical for the interaction between an αβ T cell receptor (TCR) and a peptide-bound major histocompatibility complex (pMHC) molecule to initiate productive T-cell activation. However, the underlying mechanism remains unclear. W
Externí odkaz:
https://doaj.org/article/8f049efe069f4a2bbef030ed71b32ca6
Autor:
Breane G Budaitis, Shashank Jariwala, Dana N Reinemann, Kristin I Schimert, Guido Scarabelli, Barry J Grant, David Sept, Matthew J Lang, Kristen J Verhey
Publikováno v:
eLife, Vol 8 (2019)
Kinesin force generation involves ATP-induced docking of the neck linker (NL) along the motor core. However, the roles of the proposed steps of NL docking, cover-neck bundle (CNB) and asparagine latch (N-latch) formation, during force generation are
Externí odkaz:
https://doaj.org/article/bafdd918128d451ba25c77fa2582e89f
Publikováno v:
eLife, Vol 6 (2017)
The microtubule (MT)-associated motor protein kinesin utilizes its conserved ATPase head to achieve diverse motility characteristics. Despite considerable knowledge about how its ATPase activity and MT binding are coupled to the motility cycle, the a
Externí odkaz:
https://doaj.org/article/54609733a60045418161075cda4cb866
Autor:
Kristine N Brazin, Robert J Mallis, Dibyendu Kumar Das, Yinnian eFeng, Wonmuk eHwang, Jia-huai eWang, Gerhard eWagner, Matthew J Lang, Ellis L Reinherz
Publikováno v:
Frontiers in Immunology, Vol 6 (2015)
The αβTCR was recently revealed to function as a mechanoreceptor. That is, it leverages mechanical energy generated during immune surveillance and at the immunological synapse to drive biochemical signaling following ligation by a specific foreign
Externí odkaz:
https://doaj.org/article/904e0b510a93498a9f1cc26b0fdd0007
Autor:
Jenny M Tam, Carlos E Castro, Robert J W Heath, Michael L Cardenas, Ramnik J Xavier, Matthew J Lang, Jatin M Vyas
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15215 (2010)
The application of live cell imaging allows direct visualization of the dynamic interactions between cells of the immune system. Some preliminary observations challenge long-held beliefs about immune responses to microorganisms; however, the lack of
Externí odkaz:
https://doaj.org/article/47d9eb7603b8446a965acb685d5de513
Autor:
Jonathan S. Duke-Cohan, Aoi Akitsu, Robert J. Mallis, Cameron M. Messier, Patrick H. Lizotte, Jon C. Aster, Wonmuk Hwang, Matthew J. Lang, Ellis L. Reinherz
Publikováno v:
Nature
Programming T lymphocytes to distinguish self from non-self is a vital, multi-step process arising in the thymus(1–4). Signalling through the pre-T cell receptor (preTCR), a CD3-associated heterodimer comprising an invariant pTα chain and a clone-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e7892b18e723adaf83475c6a15162d7
https://doi.org/10.1038/s41586-022-05555-7
https://doi.org/10.1038/s41586-022-05555-7
Publikováno v:
The Immune Synapse ISBN: 9781071631348
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62135a29cad820e4a1631b5bbe335349
https://doi.org/10.1007/978-1-0716-3135-5_24
https://doi.org/10.1007/978-1-0716-3135-5_24
Autor:
Mark A. Hilton, Harris W. Manning, Ireneusz Górniak, Sonia K. Brady, Madeline M. Johnson, Jochen Zimmer, Matthew J. Lang
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(40)
Cellulose biosynthesis in sessile bacterial colonies originates in the membrane-integrated bacterial cellulose synthase (Bcs) AB complex. We utilize optical tweezers to measure single-strand cellulose biosynthesis by BcsAB from Rhodobacter sphaeroide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a39f55bc21b2e5ba8594755e86d68330
https://pubmed.ncbi.nlm.nih.gov/36161928
https://pubmed.ncbi.nlm.nih.gov/36161928
Autor:
Hannah M, Stephens, Kristine N, Brazin, Robert J, Mallis, Yinnian, Feng, Debasis, Banik, Ellis L, Reinherz, Matthew J, Lang
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2478
T-cell antigen receptors (TCRs) are mechanosensors, which initiate a signaling cascade upon ligand recognition resulting in T-cell differentiation, homeostasis, effector and regulatory functions. An optical trap combined with fluorescence permits dir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3d0533bbd7171ee3d64ed55698561602
https://pubmed.ncbi.nlm.nih.gov/36063340
https://pubmed.ncbi.nlm.nih.gov/36063340
Autor:
Meghann Kasal, Hema Chandra Kotamarthi, Madeline M. Johnson, Hannah Stephens, Matthew J. Lang, Robert T. Sauer, Tania Baker
Publikováno v:
Biophysical Journal. 122:319a-320a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91a964aed657e71cf37201ebe6aff1f8
https://doi.org/10.1016/j.bpj.2022.11.1791
https://doi.org/10.1016/j.bpj.2022.11.1791