Evolution of Biologics Screening Technologies

Autor: Matthew J. Gardener, Peter Cariuk, Tristan J. Vaughan

Publikováno v: Pharmaceuticals, Vol 6, Iss 5, Pp 681-688 (2013)

Screening for biologics, in particular antibody drugs, has evolved significantly over the last 20 years. Initially, the screening processes and technologies from many years experience with small molecules were adopted and modified to suit the needs o

Externí odkaz: https://doaj.org/article/b75c4a053ef64280b9f810e804e7fb65

Cellular Prion Protein Mediates the Disruption of Hippocampal Synaptic Plasticity by Soluble TauIn Vivo

Autor: Dominic M. Walsh, Matthew J. Gardener, Jayne Hammersley, Michael S. Perkinton, Alexandra J. Mably, Tomas Ondrejcak, Wei Hong, Michael J. Rowan, Grant T. Corbett, Graham Fraser, Andrew Billinton, Igor Klyubin

Publikováno v: The Journal of Neuroscience. 38:10595-10606

Intracellular neurofibrillary tangles (NFTs) composed of tau protein are a neuropathological hallmark of several neurodegenerative diseases, the most common of which is Alzheimer's disease (AD). For some time NFTs were considered the primary cause of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8a2f3cd4ac81008f5895cf81ee08218
https://doi.org/10.1523/jneurosci.1700-18.2018

Methodologies for estimating nitrogen transfer between legumes and companion species in agro-ecosystems: A review of 15N-enriched techniques

Autor: Phillip M. Chalk, Caroline Farias Silva, Mark B. Peoples, Robert M. Boddey, Deli Chen, Murray Unkovich, Ann McNeill, Matthew J. Gardener

Publikováno v: Soil Biology and Biochemistry. 73:10-21

Methodologies based on 15N-enrichment for estimating the transfer of nitrogen (N) between legumes and companion non-legume species in agro-ecosystems are critically reviewed and classified according to whether they (i) are direct or indirect (ii) are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eae8f56e6b38052c5fe0366d45e5f175
https://doi.org/10.1016/j.soilbio.2014.02.005

Structural Characterisation Reveals Mechanism of IL-13-Neutralising Monoclonal Antibody Tralokinumab as Inhibition of Binding to IL-13Rα1 and IL-13Rα2

Autor: Jennifer Spooner, Ralph Minter, Bojana Popovic, Jason Breed, G. Colice, Trevor Wilkinson, J. Keen, Matthew J. Gardener, Tristan J. Vaughan, D.G. Rees, Lisa Marie Kitching Vinall, Benjamin Kemp, Richard D. May, F. Uddin

Publikováno v: Journal of molecular biology. 429(2)

Interleukin (IL)-13 is a pleiotropic T helper type 2 cytokine frequently associated with asthma and atopic dermatitis. IL-13-mediated signalling is initiated by binding to IL-13Rα1, which then recruits IL-4Rα to form a heterodimeric receptor comple

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9d3f7b17fee85703b28986c866dd81b
https://pubmed.ncbi.nlm.nih.gov/27956146

Histological and functional benefit following transplantation of motor neuron progenitors to the injured rat spinal cord

Autor: Hong Zhen Yin, Gabriel Nistor, Aleksandra J. Poole, Sipke Dijkstra, Sharyn L. Rossi, David F. Fischer, John H. Weiss, Matthew J. Gardener, Hans S. Keirstead, Tanya J. Wyatt

Publikováno v: PLoS ONE, Vol 5, Iss 7, p e11852 (2010)
Rossi, Sharyn L.; Nistor, Gabriel; Wyatt, Tanya; Yin, Hong Zhen; Poole, Aleksandra J.; Weiss, John H.; et al.(2010). Histological and Functional Benefit Following Transplantation of Motor Neuron Progenitors to the Injured Rat Spinal Cord. PLoS ONE, 5(7). UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/1mh3233b
PLoS ONE

Background Motor neuron loss is characteristic of cervical spinal cord injury (SCI) and contributes to functional deficit. Methodology/Principal Findings In order to investigate the amenability of the injured adult spinal cord to motor neuron differe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::287eb42ca563f1634fe3f1cd47af09ec
http://europepmc.org/articles/PMC2912300?pdf=render