Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Matthew J Eramo"'
INPP4B promotes PI3Kα-dependent late endosome formation and Wnt/β-catenin signaling in breast cancer
Autor:
Samuel J. Rodgers, Lisa M. Ooms, Viola M. J. Oorschot, Ralf B. Schittenhelm, Elizabeth V. Nguyen, Sabryn A. Hamila, Natalie Rynkiewicz, Rajendra Gurung, Matthew J. Eramo, Absorn Sriratana, Clare G. Fedele, Franco Caramia, Sherene Loi, Genevieve Kerr, Helen E. Abud, Georg Ramm, Antonella Papa, Andrew M. Ellisdon, Roger J. Daly, Catriona A. McLean, Christina A. Mitchell
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
The PI(3,4)P2 4-phosphatase, INPP4B, functions as a tumour suppressor in triple negative breast cancer. Here, the authors show that INPP4B enhances proliferation and growth of PIK3CA-mutant ER+ breast cancers by promoting PI3Kα-dependent late endoso
Externí odkaz:
https://doaj.org/article/59a5e5fde3fd4918b764c6ce08708383
Autor:
Randini Nanayakkara, Rajendra Gurung, Samuel J. Rodgers, Matthew J. Eramo, Georg Ramm, Christina A. Mitchell, Meagan J. McGrath
Publikováno v:
Autophagy. :1-18
Lysosomes are the primary degradative compartment within cells and there have been significant advances over the past decade toward understanding how lysosome homeostasis is maintained. Lysosome repopulation ensures sustained autophagy function, a fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6bfd050106eeb659a90ed23db3ca28a
https://doi.org/10.1080/15548627.2022.2128019
https://doi.org/10.1080/15548627.2022.2128019
Autor:
Avnika A. Ruparelia, Abbas Salavaty, Christopher K. Barlow, Yansong Lu, Carmen Sonntag, Lucy Hersey, Matthew J. Eramo, Johannes Krug, Hanna Reuter, Ralf B. Schittenhelm, Mirana Ramialison, Andrew Cox, Michael T. Ryan, Darren J. Creek, Christoph Englert, Peter D. Currie
Publikováno v:
Aging Cell.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b27a62131245bf1782c856741301e291
https://doi.org/10.1111/acel.13862
https://doi.org/10.1111/acel.13862
Autor:
Samuel J Rodgers, Emily I Jones, Senthil Arumugam, Sabryn A Hamila, Jill Danne, Rajendra Gurung, Matthew J Eramo, Randini Nanayakkara, Georg Ramm, Meagan J McGrath, Christina A Mitchell
Publikováno v:
The EMBO Journal. 41
Autophagy depends on the repopulation of lysosomes to degrade intracellular components and recycle nutrients. How cells co-ordinate lysosome repopulation during basal autophagy, which occurs constitutively under nutrient-rich conditions, is unknown.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::600e78f8e92a9e85bf84fc9297ea0175
https://doi.org/10.15252/embj.2021110398
https://doi.org/10.15252/embj.2021110398
INPP4B promotes PI3Kα-dependent late endosome formation and Wnt/β-catenin signaling in breast cancer
Autor:
Matthew J. Eramo, Helen E. Abud, Lisa M Ooms, Samuel J. Rodgers, Elizabeth V. Nguyen, Sabryn A. Hamila, Natalie K. Rynkiewicz, Absorn Sriratana, Georg Ramm, Genevieve Kerr, Catriona McLean, Viola Oorschot, Ralf B. Schittenhelm, Sherene Loi, Andrew M. Ellisdon, Rajendra Gurung, Christina Anne Mitchell, Clare G Fedele, Antonella Papa, Roger J. Daly, Franco Caramia
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications
Nature Communications
INPP4B suppresses PI3K/AKT signaling by converting PI(3,4)P2 to PI(3)P and INPP4B inactivation is common in triple-negative breast cancer. Paradoxically, INPP4B is also a reported oncogene in other cancers. How these opposing INPP4B roles relate to P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d2e2bc82108595261d2a16543c76a05
https://doaj.org/article/59a5e5fde3fd4918b764c6ce08708383
https://doaj.org/article/59a5e5fde3fd4918b764c6ce08708383
Publikováno v:
Autophagy. 17:1287-1289
Autophagic lysosome reformation (ALR) recycles autolysosome membranes formed during autophagy, to make lysosomes and is essential for continued autophagy function. Localized membrane remodeling on autolysosomes leads to the extension of reformation t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb49396f5e7df492348fa2d7caa68c7a
https://doi.org/10.1080/15548627.2021.1916195
https://doi.org/10.1080/15548627.2021.1916195
Publikováno v:
The Journal of Clinical Investigation
The regulation of autophagy-dependent lysosome homeostasis in vivo is unclear. We showed that the inositol polyphosphate 5-phosphatase INPP5K regulates autophagic lysosome reformation (ALR), a lysosome recycling pathway, in muscle. INPP5K hydrolyzes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::de82a3c063c7f16d4d9ae2c2223f4142
https://pubmed.ncbi.nlm.nih.gov/33119550
https://pubmed.ncbi.nlm.nih.gov/33119550
Autor:
Sandra J Feeney, Sonia Raveena Lourdes, Catriona McLean, Stefan M. Gehrig, Gordon S. Lynch, Michael Lazarou, Christina Anne Mitchell, Absorn Sriratana, Matthew J. Eramo, Rajendra Gurung, Meagan Jane Mcgrath, Frank Koentgen
Publikováno v:
Autophagy
The regulation of autophagy-dependent lysosome homeostasis in vivo is unclear. We showed that the inositol polyphosphate 5-phosphatase INPP5K regulates autophagic lysosome reformation (ALR), a lysosome recycling pathway, in muscle. INPP5K hydrolyzes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e14704e97659121574b8375cc7a48168
https://doi.org/10.1172/jci135124
https://doi.org/10.1172/jci135124
Autor:
Chrysovalantou E. Xirouchaki, Yaoyao Jia, Meagan J. McGrath, Spencer Greatorex, Melanie Tran, Troy L. Merry, Dawn Hong, Matthew J. Eramo, Sophie C. Broome, Jonathan S. T. Woodhead, Randall F. D’souza, Jenny Gallagher, Ekaterina Salimova, Cheng Huang, Ralf B. Schittenhelm, Junichi Sadoshima, Matthew J. Watt, Christina A. Mitchell, Tony Tiganis
Publikováno v:
Science Advances
Description
Exercise-induced ROS mediates antioxidant defense to attenuate oxidative damage and insulin resistance in aging and obesity.
Reactive oxygen species (ROS) generated during exercise are considered integral for the health-promotin
Exercise-induced ROS mediates antioxidant defense to attenuate oxidative damage and insulin resistance in aging and obesity.
Reactive oxygen species (ROS) generated during exercise are considered integral for the health-promotin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99f48a08d2a87dec86645084298b7d09
https://acuresearchbank.acu.edu.au/item/8y9v1/skeletal-muscle-nox4-is-required-for-adaptive-responses-that-prevent-insulin-resistance
https://acuresearchbank.acu.edu.au/item/8y9v1/skeletal-muscle-nox4-is-required-for-adaptive-responses-that-prevent-insulin-resistance
Publikováno v:
Journal of biochemistry. 167(3)
The ‘mitochondrial contact site and cristae organising system’ (MICOS) is an essential protein complex that promotes the formation, maintenance and stability of mitochondrial cristae. As such, loss of core MICOS components disrupts cristae struct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ed4a106409157aa3f9cffade5f6523b
https://pubmed.ncbi.nlm.nih.gov/31825482
https://pubmed.ncbi.nlm.nih.gov/31825482