Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Matthew J Cotton"'
Autor:
Bimarzhan Assatova, Christopher Trevisani, Robert Willim, Jessica Duffy, Abner Louissaint, Won-Seog Kim, David J Feith, Thomas Loughran, Foster Powers, Elizabeth A Morgan, Lei Yang, Brandy Pinckney, Garrett Haskett, Matthew J Cotton, Andrew Crabbe, Jessica Beth Ziemba, Ian Brain, Tayla B. Heavican-Foral, Nora Scanlan, Gail Newton, Jaehyuk Choi, Jeffrey A Barnes, Patrick Connor Johnson, Eric D Jacobsen, Steven Greenberg, David M. Weinstock, Salvia Jain
Publikováno v:
Blood. 140:2253-2255
Autor:
Christopher A. Moskaluk, Michael J. Wick, Matthew J. Cotton, Michael J. Kluk, Shawn M. Gillespie, Kaylyn E. Williamson, William C. Faquin, Christopher D. Carey, Lurdes Queimado, Jun Qi, Russell J.H. Ryan, Yotam Drier, Lynette M. Sholl, Jon C. Aster, Scott J. Rodig, Adel K. El-Naggar, James E. Bradner, A. Afrogheh, Bradley E. Bernstein, Birgit Knoechel
Publikováno v:
Nature genetics
Translocation events are frequent in cancer and may create chimeric fusions or ‘regulatory rearrangements’ that drive oncogene overexpression. Here we identify super-enhancer translocations that drive overexpression of the oncogenic transcription
Autor:
Matthew J. Cotton, Oren Ram, Laura Donohue, Shawn M. Gillespie, Michael B. Cross, Ross L. Levine, Peter van Galen, Brian B. Liau, Bradley E. Bernstein, Russell J.H. Ryan, Yotam Drier, Kaitlin M. Carroll, Aaron D. Viny, Cem Sievers
Publikováno v:
Molecular Cell. 61:170-180
Genome-wide profiling of histone modifications can provide systematic insight into the regulatory elements and programs engaged in a given cell type. However, conventional chromatin immunoprecipitation and sequencing (ChIP-seq) does not capture quant
Autor:
Matthew J. Cotton, Clifford D. Packer
Publikováno v:
Cureus
Enterococcal empyema is a rare complication of pneumonia. We report the case of a 67-year-old asplenic man with pneumonia complicated by respiratory failure and empyema requiring decortication and prolonged chest tube drainage. Cultures of the empyem
Autor:
Matthew J. Cotton, Shawn M. Gillespie, Michael J. Kluk, Mohit Jain, Bradley E. Bernstein, Dale L. Greiner, Daniel S. Pearson, Michael A. Brehm, Serena J. Silver, Manching Ku, Jens G. Lohr, Andrew L. Kung, Federica Piccioni, Alejandro Gutierrez, Daniel Fernandez, Jiang Zhu, Kimberly Stegmaier, Christopher J. Ott, Kaylyn E. Williamson, Hongfang Wang, David E. Root, Michelle A. Kelliher, Jon C. Aster, James E. Bradner, Justine E. Roderick, Birgit Knoechel, Leonard D. Shultz
Publikováno v:
Nature Genetics. 46:364-370
The identification of activating NOTCH1 mutations in T cell acute lymphoblastic leukemia (T-ALL) led to clinical testing of γ-secretase inhibitors (GSIs) that prevent NOTCH1 activation. However, responses to these inhibitors have been transient, sug
Autor:
Matthew J. Cotton, Nicole Birrer, Matthew Meyerson, Daniel Gray, Birgit Knoechel, Yotam Drier, Guangwu Guo, Bang Wong, Noopur Raje, Jesse S. Boehm, Sora Kim, Todd R. Golub, Andrew Yee, Jens G. Lohr, Joshua Gould, Cheng-Zhong Zhang, Gavin Ha
Multiple myeloma (MM) remains an incurable disease, with a treatment-refractory state eventually developing in all patients. Constant clonal evolution and genetic heterogeneity of MM are a likely explanation for the emergence of drug-resistant diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c9f07c689d03c0d2aee7fc0f9cf743b
https://europepmc.org/articles/PMC5426804/
https://europepmc.org/articles/PMC5426804/
Autor:
Russel J. Ryan, Bradley E. Bernstein, Yotam Drier, Matthew J. Cotton, Shawn M. Gillespie, Oren Ram, Laura Donohue, Cem Sievers, Peter van Galen
Publikováno v:
Experimental Hematology. 43:S99
Autor:
Marian H. Harris, Jiang Zhu, Michelle A. Kelliher, Leonard D. Shultz, Daniel S. Pearson, Justine E. Roderick, Stephen E. Sallan, Michael A. Brehm, Manching Ku, James E. Bradner, Serena J. Silver, Matthew J. Cotton, Andrew L. Kung, Mohit Jain, Daniel Fernandez, Dale L. Greiner, Hongfang Wang, Shawn M. Gillespie, Kimberly Stegmaier, Michael J. Kluk, Federica Piccioni, Alejandro Gutierrez, Christopher J. Ott, David E. Root, Birgit Knoechel, Jon C. Aster, Kaylyn E. Williamson, Jens G. Lohr, Bradley E. Bernstein, Lewis B. Silverman
Publikováno v:
Cancer Research. 74:4782-4782
Resistance to therapy is one of the major challenges in cancer treatment today, equally applicable to conventional chemotherapy as well as targeted therapy. Malignant tumors have widespread epigenetic alterations including aberrant expression of chro