Evaluation of HER2 immunohistochemistry expression in non-standard solid tumors from a Single-Institution Prospective Cohort

Autor: Saurav Verma, Amanda Chapman, Lee-Anne Pickard, Danielle Porplycia, Haley McConkey, Patricia Jarosz, James Sinfield, Carolyn Lauzon-Young, Matthew J Cecchini, Christopher Howlett, Natalie Grindrod, Bekim Sadikovic, Stephen A Welch, Daniel Breadner

Publikováno v: Exploration of Targeted Anti-tumor Therapy, Vol 5, Iss 5, Pp 1100-1109 (2024)

Aim: Human epidermal growth factor receptor-2 (HER2) is a well-established prognostic and predictive biomarker. It is an FDA-approved therapeutic target for HER2 positive breast, gastroesophageal, and more recently, lung and colon cancers. It is an e

Externí odkaz: https://doaj.org/article/c7445bbea1f8499886868b62467305d3

Digital quantification of p16-positive foci in fibrotic interstitial lung disease is associated with a phenotype of idiopathic pulmonary fibrosis with reduced survival

Autor: Jonathan Keow, Matthew J. Cecchini, Nathashi Jayawardena, Maurizio Zompatori, Mariamma G. Joseph, Marco Mura

Publikováno v: Respiratory Research, Vol 23, Iss 1, Pp 1-13 (2022)

Abstract Background Idiopathic pulmonary fibrosis (IPF) is associated with increased expression of cyclin-dependent kinase inhibitors such as p16 and p21, and subsequent induction of cell cycle arrest, cellular senescence, and pro-fibrotic gene expre

Externí odkaz: https://doaj.org/article/6c05baa7dcc4466abc2421858d117edf

Supplementary Figure Legends from Haploinsufficiency of an RB–E2F1–Condensin II Complex Leads to Aberrant Replication and Aneuploidy

Autor: Frederick A. Dick, Grant W. Brown, Paul C. Boutros, Ian Welch, Vanessa Percy, Alison L. Martens, Matthew J. Cecchini, Jianxin Wang, Srikanth Talluri, Aren Marshall, David Gallo, Charles A. Ishak, Courtney H. Coschi

PDF fie 148K, Description of additional genotypes of cells analyzed for gammaH2AX distribution and detailed instability phenotypes of heterozygous cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::226390837fe1927a4626327b86ffb2d9
https://doi.org/10.1158/2159-8290.22529607

Digital Quantification of Tumor Cellularity as a Novel Prognostic Feature of Non–Small Cell Lung Carcinoma

Autor: Sherman Lin, Joshua P. Samsoondar, Ela Bandari, Samantha Keow, Binit Bikash, Djarren Tan, Jacobo Martinez-Acevedo, John Loggie, Michelle Pham, Nina J. Wu, Tanya Misra, Victor H.K. Lam, Irene Sansano, Matthew J. Cecchini

Publikováno v: Scientia

Cancer; Image analysis; Thoracic pathology Càncer; Anàlisi d'imatges; Patologia toràcica Cáncer; Análisis de imágenes; Patología torácica Non–small cell lung carcinoma is currently staged based on the size and involvement of other structure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c4ca063be0ae62844788bb19a102e67
https://hdl.handle.net/11351/9165

Immune-based classification of HPV-associated oropharyngeal cancer with implications for biomarker-driven treatment de-intensification

Autor: Peter Y.F. Zeng, Matthew J. Cecchini, John W. Barrett, Matthew Shammas-Toma, Loris De Cecco, Mara S. Serafini, Stefano Cavalieri, Lisa Licitra, Frank Hoebers, Ruud H. Brakenhoff, C. René Leemans, Kathrin Scheckenbach, Tito Poli, Xiaowei Wang, Xinyi Liu, Francisco Laxague, Eitan Prisman, Catherine Poh, Pinaki Bose, Joseph C. Dort, Mushfiq H. Shaikh, Sarah E.B. Ryan, Alice Dawson, Mohammed I. Khan, Christopher J. Howlett, William Stecho, Paul Plantinga, Sabrina Daniela da Silva, Michael Hier, Halema Khan, Danielle MacNeil, Adrian Mendez, John Yoo, Kevin Fung, Pencilla Lang, Eric Winquist, David A. Palma, Hedyeh Ziai, Antonio L. Amelio, Shawn S-C. Li, Paul C. Boutros, Joe S. Mymryk, Anthony C. Nichols

Publikováno v: Zeng, P Y F, Cecchini, M J, Barrett, J W, Shammas-Toma, M, de Cecco, L, Serafini, M S, Cavalieri, S, Licitra, L, Hoebers, F, Brakenhoff, R H, Leemans, C R, Scheckenbach, K, Poli, T, Wang, X, Liu, X, Laxague, F, Prisman, E, Poh, C, Bose, P, Dort, J C, Shaikh, M H, Ryan, S E B, Dawson, A, Khan, M I, Howlett, C J, Stecho, W, Plantinga, P, Daniela da Silva, S, Hier, M, Khan, H, MacNeil, D, Mendez, A, Yoo, J, Fung, K, Lang, P, Winquist, E, Palma, D A, Ziai, H, Amelio, A L, Li, S S C, Boutros, P C, Mymryk, J S & Nichols, A C 2022, ' Immune-based classification of HPV-associated oropharyngeal cancer with implications for biomarker-driven treatment de-intensification ', EBioMedicine, vol. 86, 104373 . https://doi.org/10.1016/j.ebiom.2022.104373
EBioMedicine, 86:104373. Elsevier
EBioMedicine, 86:104373. Elsevier BV

Background There is significant interest in treatment de-escalation for human papillomavirus-associated (HPV+) oropharyngeal squamous cell carcinoma (OPSCC) patients given the generally favourable prognosis. However, 15-30% of patients recur after pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d51ac0f0080a9a1d21322b765aa63ad
https://research.vumc.nl/en/publications/f13e1844-728f-4dc6-8f0c-bc374ebc4107