Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Matthew J Bottomley"'
Autor:
Hannah Beckwith, Michael Nation, Aisling McMahon, David C Wheeler, Matthew J Bottomley, Neil S Sheerin, Jeremy Hughes, Sharlene Greenwood
Publikováno v:
BMJ Open, Vol 12, Iss 12 (2022)
Objectives To establish barriers and motivators underlying research engagement among early-career practitioners in nephrology across the UK, in order to guide potential interventions to enhance research involvement in renal units.Design Cross-section
Externí odkaz:
https://doaj.org/article/644000dbb14d42f4af9f76bad3e38632
Autor:
Emanuele Andreano, Ida Paciello, Monia Bardelli, Simona Tavarini, Chiara Sammicheli, Elisabetta Frigimelica, Silvia Guidotti, Giulia Torricelli, Marco Biancucci, Ugo D’Oro, Sumana Chandramouli, Matthew J Bottomley, Rino Rappuoli, Oretta Finco, Francesca Buricchi
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 6, Pp n/a-n/a (2021)
Abstract Respiratory syncytial virus (RSV) is the leading cause of death from lower respiratory tract infection in infants and children, and is responsible for considerable morbidity and mortality in older adults. Vaccines for pregnant women and elde
Externí odkaz:
https://doaj.org/article/7401702b0b794eb9a186351c1a095d31
Autor:
Daniele Veggi, Federica Bianchi, Laura Santini, Paola Lo Surdo, Chelsy C Chesterman, Werner Pansegrau, Nicoletta Bechi, Ying Huang, Vega Masignani, Mariagrazia Pizza, Rino Rappuoli, Matthew J Bottomley, Roberta Cozzi, Domenico Maione
Publikováno v:
PLoS Pathogens, Vol 16, Iss 10, p e1008882 (2020)
Neisseria meningitidis serogroup B (MenB) is the leading cause of meningococcal meningitis and sepsis in industrialized countries, with the highest incidence in infants and adolescents. Two recombinant protein vaccines that protect against MenB are n
Externí odkaz:
https://doaj.org/article/c9190e4ed8cc4c1ba891c65d2e1fd686
Autor:
Daniele Veggi, Chelsy C. Chesterman, Laura Santini, Ying Huang, Nicola Pacchiani, Jeannette Sierra, Lynn Chen, Jason Laliberte, Federica Bianchi, Roberta Cozzi, Elisabetta Frigimelica, Domenico Maione, Oretta Finco, Matthew J. Bottomley
Publikováno v:
FASEB BioAdvances, Vol 6, Iss 8, Pp 235-248 (2024)
Abstract Thousands of disease cases and hundreds of deaths occur globally each year due to invasive meningococcal disease. Neisseria meningitidis serogroup B (MenB) is the leading cause of such disease in developed countries. Two vaccines, 4CMenB and
Externí odkaz:
https://doaj.org/article/9b599c9365e449dfb0b143e66a3cfe14
Autor:
Martina Maritan, Daniele Veggi, Roberta Cozzi, Lucia Dello Iacono, Erika Bartolini, Paola Lo Surdo, Giulietta Maruggi, Glen Spraggon, Matthew J Bottomley, Enrico Malito
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0201922 (2018)
Neisserial heparin binding antigen (NHBA) is one of three main recombinant protein antigens in 4CMenB, a vaccine for the prevention of invasive meningococcal disease caused by Neisseria meningitidis serogroup B. NHBA is a surface-exposed lipoprotein
Externí odkaz:
https://doaj.org/article/cee79a5c92024499b9bc57caebc05e1d
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Chronic kidney disease affects 1 in 10 people globally, with a prevalence twenty times that of cancer. A subset of individuals will progress to end-stage renal disease (ESRD) where renal replacement therapy is required to maintain health. Cutaneous d
Externí odkaz:
https://doaj.org/article/e786ca70c02843f9a2732abca0e3258b
Autor:
Alessia Liguori, Enrico Malito, Paola Lo Surdo, Luca Fagnocchi, Francesca Cantini, Andreas F Haag, Sébastien Brier, Mariagrazia Pizza, Isabel Delany, Matthew J Bottomley
Publikováno v:
PLoS Pathogens, Vol 12, Iss 4, p e1005557 (2016)
Neisseria adhesin A (NadA) is present on the meningococcal surface and contributes to adhesion to and invasion of human cells. NadA is also one of three recombinant antigens in the recently-approved Bexsero vaccine, which protects against serogroup B
Externí odkaz:
https://doaj.org/article/fe26d987d2f647f6a06de8fb4b7f80d5
Autor:
Roberta Cozzi, Enrico Malito, Maddalena Lazzarin, Annalisa Nuccitelli, Andrea Castagnetti, Matthew J Bottomley, Immaculada Margarit, Domenico Maione, C Daniela Rinaudo
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0125875 (2015)
Group B Streptococcus (GBS) is a major cause of invasive disease in infants. Like other Gram-positive bacteria, GBS uses a sortase C-catalyzed transpeptidation mechanism to generate cell surface pili from backbone and ancillary pilin precursor substr
Externí odkaz:
https://doaj.org/article/d63fff1033f4475e9a94fdcb7d942118
Autor:
Roberta Cozzi, Daniil Prigozhin, Roberto Rosini, Francesca Abate, Matthew J Bottomley, Guido Grandi, John L Telford, C Daniela Rinaudo, Domenico Maione, Tom Alber
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49048 (2012)
Gram-positive bacteria assemble pili through class C sortase enzymes specialized in polymerizing pilin subunits into covalently linked, high-molecular-weight, elongated structures. Here we report the crystal structures of two class C sortases (SrtC1
Externí odkaz:
https://doaj.org/article/e5a5c9bd38f241e79d383985c730baf0
Publikováno v:
eJHaem. 4:291-293