Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Matthew J, Niederst"'
Autor:
David P. Kodack, Anna F. Farago, Anahita Dastur, Matthew A. Held, Leila Dardaei, Luc Friboulet, Friedrich von Flotow, Leah J. Damon, Dana Lee, Melissa Parks, Richard Dicecca, Max Greenberg, Krystina E. Kattermann, Amanda K. Riley, Florian J. Fintelmann, Coleen Rizzo, Zofia Piotrowska, Alice T. Shaw, Justin F. Gainor, Lecia V. Sequist, Matthew J. Niederst, Jeffrey A. Engelman, Cyril H. Benes
Publikováno v:
Cell Reports, Vol 21, Iss 11, Pp 3298-3309 (2017)
Personalized cancer therapy is based on a patient’s tumor lineage, histopathology, expression analyses, and/or tumor DNA or RNA analysis. Here, we aim to develop an in vitro functional assay of a patient’s living cancer cells that could complemen
Externí odkaz:
https://doaj.org/article/016db17b42214179a6109aad4764e0a1
Autor:
Lecia V. Sequist, Jeffrey A. Engelman, Andrew R. Allen, Alice T. Shaw, A. John Iafrate, Dora Dias-Santagata, Richard H. DiCecca, Melissa K. Parks, Hillary E. Mulvey, Angel R. Garcia, Mitch Raponi, Alona Muzikansky, Subba Digumarthy, Anuj Kalsy, Elizabeth L. Lockerman, Aaron N. Hata, Linnea Fulton, Mari Mino-Kenudson, Joel W. Neal, Heather A. Wakelee, Chris A. Karlovich, Matthew J. Niederst, Zofia Piotrowska
Supplementary Figure S1. CONSORT diagram. Supplementary Figure S2. Histologic analysis of the pre-rociletinib biopsy from patient 12 (H&E 400x, left panel) demonstrates characteristic adenocarcinoma with an open chromatin pattern, ample cytoplasm and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::437ca3efda6e4b1a14798fe61a036ad6
https://doi.org/10.1158/2159-8290.22530498.v1
https://doi.org/10.1158/2159-8290.22530498.v1
Autor:
Lecia V. Sequist, Jeffrey A. Engelman, Andrew R. Allen, Alice T. Shaw, A. John Iafrate, Dora Dias-Santagata, Richard H. DiCecca, Melissa K. Parks, Hillary E. Mulvey, Angel R. Garcia, Mitch Raponi, Alona Muzikansky, Subba Digumarthy, Anuj Kalsy, Elizabeth L. Lockerman, Aaron N. Hata, Linnea Fulton, Mari Mino-Kenudson, Joel W. Neal, Heather A. Wakelee, Chris A. Karlovich, Matthew J. Niederst, Zofia Piotrowska
Supplementary Figure Legends. Supplementary Table S1. Patient characteristics. Supplementary Table S2. Tissue genotyping analyses. Supplementary Table S3. Allelic Fraction of T790M and maximum reduction in tumor volume in response to rociletinib.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03fcd94a89f7fb896d66c6fc6bab2516
https://doi.org/10.1158/2159-8290.22530501
https://doi.org/10.1158/2159-8290.22530501
Autor:
Anthony C. Faber, Jeffrey A. Engelman, Hiromichi Ebi, Bradley Bernstein, Lecia V. Sequist, Mikhail Dozmorov, Shirley M. Taylor, Sinem E. Sahingur, Zofia Piotrowska, Brad E. Windle, Tara J. Nulton, Maria Gomez-Caraballo, Hannah L. Archibald, Shawn Gillepsie, Angel Garcia, Elizabeth L. Lockerman, Neha U. Patel, Mark T. Hughes, Daniel A.R. Heisey, Yotam Drier, Hillary E. Mulvey, Haichuan Hu, Mark A. Hicks, Konstantinos V. Floros, Jungoh Ham, Hidenori Kitai, Aaron N. Hata, Timothy L. Lochmann, Matthew J. Niederst, Kyung-A Song
Top 10 correlated genes to BIM (BCL2L11)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28634790899e5554faee70782d605662
https://doi.org/10.1158/1078-0432.22462244.v1
https://doi.org/10.1158/1078-0432.22462244.v1
Autor:
Jeffrey A. Engelman, Lecia V. Sequist, Zofia Piotrowska, Angel R. Garcia, Elizabeth L. Lockerman, Hillary E. Mulvey, Haichuan Hu, Matthew J. Niederst
Supplementary Figure 1 Legend. Describing the qPCR assay and variant allele frequency data that are included in the figure.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e18167c22ba9c0611b588fce9c6740d
https://doi.org/10.1158/1078-0432.22457907
https://doi.org/10.1158/1078-0432.22457907
Autor:
Anthony C. Faber, Jeffrey A. Engelman, Hiromichi Ebi, Bradley Bernstein, Lecia V. Sequist, Mikhail Dozmorov, Shirley M. Taylor, Sinem E. Sahingur, Zofia Piotrowska, Brad E. Windle, Tara J. Nulton, Maria Gomez-Caraballo, Hannah L. Archibald, Shawn Gillepsie, Angel Garcia, Elizabeth L. Lockerman, Neha U. Patel, Mark T. Hughes, Daniel A.R. Heisey, Yotam Drier, Hillary E. Mulvey, Haichuan Hu, Mark A. Hicks, Konstantinos V. Floros, Jungoh Ham, Hidenori Kitai, Aaron N. Hata, Timothy L. Lochmann, Matthew J. Niederst, Kyung-A Song
Supplemental legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cdf55fda2d52240554b29e627d0a09c
https://doi.org/10.1158/1078-0432.22462238
https://doi.org/10.1158/1078-0432.22462238
Autor:
Jeffrey A. Engelman, Lecia V. Sequist, Zofia Piotrowska, Angel R. Garcia, Elizabeth L. Lockerman, Hillary E. Mulvey, Haichuan Hu, Matthew J. Niederst
Purpose: A secondary EGFR mutation, T790M, is the most common resistance mechanism in EGFR-mutant adenocarcinomas that have progressed on erlotinib. Third-generation EGFR inhibitors capable of inhibiting mutant EGFR with T790M produce responses in ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59e3f5cd6fe326d292cde875d4764bd7
https://doi.org/10.1158/1078-0432.c.6523746.v1
https://doi.org/10.1158/1078-0432.c.6523746.v1
Autor:
Anthony C. Faber, Jeffrey A. Engelman, Hiromichi Ebi, Bradley Bernstein, Lecia V. Sequist, Mikhail Dozmorov, Shirley M. Taylor, Sinem E. Sahingur, Zofia Piotrowska, Brad E. Windle, Tara J. Nulton, Maria Gomez-Caraballo, Hannah L. Archibald, Shawn Gillepsie, Angel Garcia, Elizabeth L. Lockerman, Neha U. Patel, Mark T. Hughes, Daniel A.R. Heisey, Yotam Drier, Hillary E. Mulvey, Haichuan Hu, Mark A. Hicks, Konstantinos V. Floros, Jungoh Ham, Hidenori Kitai, Aaron N. Hata, Timothy L. Lochmann, Matthew J. Niederst, Kyung-A Song
ZEB1 binding sites found in 1975R2 cells compared to 1975 parental cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2a27042f9ca1b22d872df72208f56c4
https://doi.org/10.1158/1078-0432.22462241
https://doi.org/10.1158/1078-0432.22462241
Autor:
Anthony C. Faber, Jeffrey A. Engelman, Hiromichi Ebi, Bradley Bernstein, Lecia V. Sequist, Mikhail Dozmorov, Shirley M. Taylor, Sinem E. Sahingur, Zofia Piotrowska, Brad E. Windle, Tara J. Nulton, Maria Gomez-Caraballo, Hannah L. Archibald, Shawn Gillepsie, Angel Garcia, Elizabeth L. Lockerman, Neha U. Patel, Mark T. Hughes, Daniel A.R. Heisey, Yotam Drier, Hillary E. Mulvey, Haichuan Hu, Mark A. Hicks, Konstantinos V. Floros, Jungoh Ham, Hidenori Kitai, Aaron N. Hata, Timothy L. Lochmann, Matthew J. Niederst, Kyung-A Song
Purpose: Epithelial-to-mesenchymal transition (EMT) confers resistance to a number of targeted therapies and chemotherapies. However, it has been unclear why EMT promotes resistance, thereby impairing progress to overcome it.Experimental Design: We h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d2dd5859ffe827d68fb39cfaad05bff
https://doi.org/10.1158/1078-0432.c.6525047.v1
https://doi.org/10.1158/1078-0432.c.6525047.v1
Autor:
Jeffrey A. Engelman, Lecia V. Sequist, Zofia Piotrowska, Angel R. Garcia, Elizabeth L. Lockerman, Hillary E. Mulvey, Haichuan Hu, Matthew J. Niederst
Supplementary Figure 1. EGFR amplification status and variant allele frequencies of T790M and C797S mutations for MGH121 parental and MGH121 resistant #1 cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d730bf07d9b78031685d846a53f6defb
https://doi.org/10.1158/1078-0432.22457904.v1
https://doi.org/10.1158/1078-0432.22457904.v1