Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Matthew J, Langton"'
Publikováno v:
ACS Omega, Vol 9, Iss 45, Pp 45572-45580 (2024)
Externí odkaz:
https://doaj.org/article/3b6bfdc7150b4348b3aa4aae68d1432a
Halogen bonding relay and mobile anion transporters with kinetically controlled chloride selectivity
Selective transmembrane transport of chloride over competing proton or hydroxide transport is key for the therapeutic applications of anionophores, but remains a significant challenge. Current approaches rely on enhancing chloride anion encapsulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfd9a439a55d19dae43d09a4039c0081
https://ora.ox.ac.uk/objects/uuid:cb23cc8c-16d1-46a7-90b6-8f6d727fb6f1
https://ora.ox.ac.uk/objects/uuid:cb23cc8c-16d1-46a7-90b6-8f6d727fb6f1
Publikováno v:
Chemical Science. 13:11551-11559
Molecular photoswitches operating in the red to near-IR region with controllable thermal relaxation rates are attractive components for photo-regulating biological processes. Herein, we report the synthesis of red-shifted azobenzenes functionalised w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8510964d063d72842b1f6d3572658e05
https://doi.org/10.1039/d2sc04601f
https://doi.org/10.1039/d2sc04601f
Synthetic supramolecular transmembrane anionophores have emerged as promising anticancer chemotherapeutics. However, key to their targeted application is achieving spatiotemporally controlled activity. Herein, we report a series of chalcogen-bonding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::299454a12b3755c7c7915cfaa95d5e3c
https://ora.ox.ac.uk/objects/uuid:dca2c96a-bd94-496e-8eee-457728dd191f
https://ora.ox.ac.uk/objects/uuid:dca2c96a-bd94-496e-8eee-457728dd191f
Publikováno v:
Chemical communications (Cambridge, England).
Photo-switchable receptors allow for photo-control over guest binding and release with spatial and temporal precision. Here we report the first halogen bonding photo-switchable anion receptors in which chloride binding may be reversibly modulated by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dac1271a0b72543ac041b1d3c2f02783
https://pubmed.ncbi.nlm.nih.gov/36440635
https://pubmed.ncbi.nlm.nih.gov/36440635
Autor:
Laura E. Bickerton, Matthew J. Langton
Stimuli-responsive transmembrane ion carriers allow for targeted and controllable transport activity, with potential applications as therapeutics for channelopathies and cancer, and in fundamental studies into ion transport phenomena. These applicati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28c55b2b9480d3619a70411046b22456
https://doi.org/10.1039/d2sc03322d
https://doi.org/10.1039/d2sc03322d
Autor:
Laura E, Bickerton, Matthew J, Langton
Publikováno v:
Chemical science. 13(33)
Stimuli-responsive transmembrane ion carriers allow for targeted and controllable transport activity, with potential applications as therapeutics for channelopathies and cancer, and in fundamental studies into ion transport phenomena. These applicati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bb44ba6e233f2892ec1a583f81ff0b41
https://pubmed.ncbi.nlm.nih.gov/36091898
https://pubmed.ncbi.nlm.nih.gov/36091898
Ion transport across lipid membranes in biology is controlled by stimuli-responsive membrane channels and molecular machine ion pumps such as ATPases. Here, we report a synthetic molecular machine-like ion transport relay, in which transporters on op
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b951eaea311937892aff9773ebd07d9
https://ora.ox.ac.uk/objects/uuid:63420e38-c227-4b01-a3fa-420758dfa3f7
https://ora.ox.ac.uk/objects/uuid:63420e38-c227-4b01-a3fa-420758dfa3f7
Autor:
Matthew J. Langton
Publikováno v:
Nature Reviews Chemistry. 5:46-61
The membrane proteins found in nature control many important cellular functions, including signal transduction and transmembrane ion transport, and these, in turn, are regulated by external stimuli, such as small molecules, membrane potential and lig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f14b3d107c40fb29da92327d15e670b
https://doi.org/10.1038/s41570-020-00233-6
https://doi.org/10.1038/s41570-020-00233-6
Transmembrane anion transport mediated by halogen bonding and hydrogen bonding triazole anionophores
Publikováno v:
Chemical Science
Chemical science, vol 11, iss 18
Chemical science, vol 11, iss 18
Transmembrane ion transport by synthetic anionophores is typically achieved using polar hydrogen bonding anion receptors. Here we show that readily accessible halogen and hydrogen bonding 1,2,3-triazole derivatives can efficiently mediate anion trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a2b3305d41e9c0ebd8f1dccc0613ca1
https://doi.org/10.1039/d0sc01467b
https://doi.org/10.1039/d0sc01467b