Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Matthew J, Kennedy"'
Autor:
Dean J. Kareemo, Christina S. Winborn, Samantha S. Olah, Carley N. Miller, JungMin Kim, Chelsie A. Kadgien, Hannah S. Actor-Engel, Harrison J. Ramsay, Austin M. Ramsey, Jason Aoto, Matthew J. Kennedy
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Tools for visualizing and manipulating protein dynamics in living cells are critical for understanding cellular function. Here we leverage recently available monoclonal antibody sequences to generate a set of affinity tags for labeling and m
Externí odkaz:
https://doaj.org/article/6994164957e4485a81f9f49a4d105b62
Autor:
John W. Kennedy, Elliot J. Rooney, Paul J. Ryan, Soorya Siva, Matthew J. Kennedy, Ben Wheelwright, David Young, R. M. D. Meek
Publikováno v:
Bone & Joint Open, Vol 5, Iss 6, Pp 452-456 (2024)
Aims: Femoral periprosthetic fractures are rising in incidence. Their management is complex and carries a high associated mortality. Unlike native hip fractures, there are no guidelines advising on time to theatre in this group. We aim to determine w
Externí odkaz:
https://doaj.org/article/21db46b02ba84365b8b400d3c7b6c0ff
Autor:
Samantha S. Olah, Dean J. Kareemo, William C. Buchta, Brooke L. Sinnen, Carley N. Miller, Hannah S. Actor-Engel, Sara E. Gookin, Christina S. Winborn, Mason S. Kleinjan, Kevin C. Crosby, Jason Aoto, Katharine R. Smith, Matthew J. Kennedy
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113331- (2023)
Summary: Neurotransmitter receptors partition into nanometer-scale subdomains within the postsynaptic membrane that are precisely aligned with presynaptic neurotransmitter release sites. While spatial coordination between pre- and postsynaptic elemen
Externí odkaz:
https://doaj.org/article/3444965cf8894b45b28692c79eca5faf
Autor:
Harrison J. Ramsay, Sara E. Gookin, Austin M. Ramsey, Dean J. Kareemo, Kevin C. Crosby, Dominik G. Stich, Samantha S. Olah, Hannah S. Actor-Engel, Katharine R. Smith, Matthew J. Kennedy
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Postsynaptic neurotransmitter receptors and their associated scaffolding proteins assemble into discrete, nanometer-scale subsynaptic domains (SSDs) within the postsynaptic membrane at both excitatory and inhibitory synapses. Intriguingly, postsynapt
Externí odkaz:
https://doaj.org/article/0a611978cc574cd884372c1cb950f914
Publikováno v:
Bone & Joint Open, Vol 3, Iss 3, Pp 218-228 (2022)
Aims Our objective was to conduct a systematic review and meta-analysis, to establish whether differences arise in clinical outcomes between autologous and synthetic bone grafts in the operative management of tibial plateau fractures. Methods A struc
Externí odkaz:
https://doaj.org/article/c28c550da1dc4de885e06939d012df1f
Autor:
Sara E. Gookin, Matthew R. Taylor, Samantha L. Schwartz, Matthew J. Kennedy, Mark L. Dell’Acqua, Kevin C. Crosby, Katharine R. Smith
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 14 (2022)
The nanoscale architecture of synapses has been investigated using multiple super-resolution methods, revealing a common modular structure for scaffolds, neurotransmitter receptors, and presynaptic proteins. This fundamental organization of proteins
Externí odkaz:
https://doaj.org/article/ce3db4c3150a42509ceaf51515256aad
Autor:
Jonathan E. Tullis, Olivia R. Buonarati, Steven J. Coultrap, Ashley M. Bourke, Erika L. Tiemeier, Matthew J. Kennedy, Paco S. Herson, K. Ulrich Bayer
Publikováno v:
iScience, Vol 24, Iss 10, Pp 103214- (2021)
Summary: Binding of two different CaM kinases, CaMKII and DAPK1, to the NMDA-type glutamate receptor (NMDAR) subunit GluN2B near S1303 has been implicated in excitotoxic/ischemic neuronal cell death. The GluN2BΔCaMKII mutation (L1298A, R1300Q) is ne
Externí odkaz:
https://doaj.org/article/f415611452a44fc8862991682f4e7cfa
Autor:
Brian G. Hiester, Ashley M. Bourke, Brooke L. Sinnen, Sarah G. Cook, Emily S. Gibson, Katharine R. Smith, Matthew J. Kennedy
Publikováno v:
Cell Reports, Vol 21, Iss 8, Pp 2134-2146 (2017)
The repertoire and abundance of proteins displayed on the surface of neuronal dendrites are tuned by regulated fusion of recycling endosomes (REs) with the dendritic plasma membrane. While this process is critical for neuronal function and plasticity
Externí odkaz:
https://doaj.org/article/c6d4bff6bfc64e148fb2bd02f5186df3
Autor:
Angela R. Wild, Brooke L. Sinnen, Philip J. Dittmer, Matthew J. Kennedy, William A. Sather, Mark L. Dell’Acqua
Publikováno v:
Cell Reports, Vol 26, Iss 13, Pp 3537-3550.e4 (2019)
Summary: Long-term information storage in the brain requires continual modification of the neuronal transcriptome. Synaptic inputs located hundreds of micrometers from the nucleus can regulate gene transcription, requiring high-fidelity, long-range s
Externí odkaz:
https://doaj.org/article/6ce51fc0392c409f9aedb860a58b1965
Autor:
Raphael Wolfisberg, Kenn Holmbeck, Eva Billerbeck, Caroline E. Thorselius, Mariana N. Batista, Ulrik Fahnøe, Emma A. Lundsgaard, Matthew J. Kennedy, Louise Nielsen, Charles M. Rice, Jens Bukh, Troels K. H. Scheel
Publikováno v:
Journal of Virology. 97
A prophylactic vaccine is required to achieve the World Health Organization’s objective for hepatitis C virus elimination as a serious public health threat. However, the lack of robust immunocompetent animal models supporting hepatitis C virus infe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3114c3aec15d2f2f4562ebeb60c1f1d
https://doi.org/10.1128/jvi.01812-22
https://doi.org/10.1128/jvi.01812-22