Výsledky vyhledávání - "Matthew J, Hilton"

Akademický článek

STING suppresses bone cancer pain via immune and neuronal modulation

Autor: Kaiyuan Wang, Christopher R. Donnelly, Changyu Jiang, Yihan Liao, Xin Luo, Xueshu Tao, Sangsu Bang, Aidan McGinnis, Michael Lee, Matthew J. Hilton, Ru-Rong Ji

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)

There is an unmet clinical need to develop therapies to alleviate metastatic bone pain, frequently observed in patients with advanced cancers. Here, using mouse models of bone cancer pain, the authors show that STING agonists not only suppress bone c

Externí odkaz: https://doaj.org/article/d82ef968c2e84210ad88047195778682

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Akademický článek

Hypertrophic chondrocytes serve as a reservoir for marrow-associated skeletal stem and progenitor cells, osteoblasts, and adipocytes during skeletal development

Autor: Jason T Long, Abigail Leinroth, Yihan Liao, Yinshi Ren, Anthony J Mirando, Tuyet Nguyen, Wendi Guo, Deepika Sharma, Douglas Rouse, Colleen Wu, Kathryn Song Eng Cheah, Courtney M Karner, Matthew J Hilton

Publikováno v: eLife, Vol 11 (2022)

Hypertrophic chondrocytes give rise to osteoblasts during skeletal development; however, the process by which these non-mitotic cells make this transition is not well understood. Prior studies have also suggested that skeletal stem and progenitor cel

Externí odkaz: https://doaj.org/article/e5000bdddb6c48f5925edceea43da35c

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Akademický článek

Aged G Protein-Coupled Receptor Kinase 3 (Grk3)-Deficient Mice Exhibit Enhanced Osteoclastogenesis and Develop Bone Lesions Analogous to Human Paget’s Disease of Bone

Autor: Emily M. Rabjohns, Rishi R. Rampersad, Arin Ghosh, Katlyn Hurst, Amanda M. Eudy, Jaime M. Brozowski, Hyun Ho Lee, Yinshi Ren, Anthony Mirando, Justin Gladman, Jessica L. Bowser, Kathryn Berg, Sachin Wani, Stuart H. Ralston, Matthew J. Hilton, Teresa K. Tarrant

Publikováno v: Cells, Vol 12, Iss 7, p 981 (2023)

Paget’s Disease of Bone (PDB) is a metabolic bone disease that is characterized by dysregulated osteoclast function leading to focal abnormalities of bone remodeling. It can lead to pain, fracture, and bone deformity. G protein-coupled receptor kin

Externí odkaz: https://doaj.org/article/d4ebb64765294ed991aa8881105b3d2b

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Akademický článek

HES1 is a novel downstream modifier of the SHH-GLI3 Axis in the development of preaxial polydactyly.

Autor: Deepika Sharma, Anthony J Mirando, Abigail Leinroth, Jason T Long, Courtney M Karner, Matthew J Hilton

Publikováno v: PLoS Genetics, Vol 17, Iss 12, p e1009982 (2021)

Sonic Hedgehog/GLI3 signaling is critical in regulating digit number, such that Gli3-deficiency results in polydactyly and Shh-deficiency leads to digit number reductions. SHH/GLI3 signaling regulates cell cycle factors controlling mesenchymal cell p

Externí odkaz: https://doaj.org/article/c0ddf0fe38a04ddc84c2ce80fbc65e0e

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Akademický článek

Hypoxia depletes contaminating CD45+ hematopoietic cells from murine bone marrow stromal cell (BMSC) cultures: Methods for BMSC culture purification

Autor: Wendi Guo, Kassandra V. Spiller, Jackie Tang, Courtney M. Karner, Matthew J. Hilton, Colleen Wu

Publikováno v: Stem Cell Research, Vol 53, Iss , Pp 102317- (2021)

Culture expanded bone marrow stromal cells (BMSCs) are easily isolated, can be grown rapidly en masse, and contain both skeletal stem cells (SSCs) and multipotent mesenchymal progenitors (MMPs). Despite this functional heterogeneity, BMSCs continue t

Externí odkaz: https://doaj.org/article/ab4998df30f04e229bd151da11861c1e

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Akademický článek

Dysregulation of STAT3 signaling is associated with endplate-oriented herniations of the intervertebral disc in Adgrg6 mutant mice.

Autor: Zhaoyang Liu, Garrett W D Easson, Jingjing Zhao, Nadja Makki, Nadav Ahituv, Matthew J Hilton, Simon Y Tang, Ryan S Gray

Publikováno v: PLoS Genetics, Vol 15, Iss 10, p e1008096 (2019)

Degenerative changes of the intervertebral disc (IVD) are a leading cause of disability affecting humans worldwide and has been attributed primarily to trauma and the accumulation of pathology during aging. While genetic defects have also been associ

Externí odkaz: https://doaj.org/article/849d9c78e64042ffb4d7763adfacb2c9

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Histologic Differences in Human Rotator Cuff Muscle Based on Tear Characteristics

Autor: Lindsey Ruderman, Abigail Leinroth, Helen Rueckert, Troy Tabarestani, Rafeal Baker, Jay Levin, Chad E. Cook, Christopher S. Klifto, Matthew J. Hilton, Oke Anakwenze

Publikováno v: Journal of Bone and Joint Surgery. 104:1148-1156

Fatty accumulation in the rotator cuff is associated with shoulder dysfunction and a risk of failure of rotator cuff repair. The aims of this study were to (1) describe cellular findings in rotator cuff muscles in patients presenting with varying deg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5e216ae55e1407243b2177685b34140
https://doi.org/10.2106/jbjs.21.01304

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