Výsledky vyhledávání - "Matthew I. Milstein"

Phase II Clinical Trial of Everolimus in a Pan-Cancer Cohort of Patients with mTOR Pathway Alterations

Autor: David M. Hyman, Lynette M. Sholl, Katherine Kargus, Hebert Alberto Vargas, Ann E. Sisk, Elio Adib, James J. Harding, Solida Pruitt-Thompson, Krinio Giannikou, Jennifer Hedglin, Martin H. Voss, Khanh T. Do, Ketki Bhushan, Matthew I. Milstein, David J. Kwiatkowski, Gopa Iyer, Geoffrey I. Shapiro, Junko Tsuji, Katarzyna Klonowska

Publikováno v: Clinical Cancer Research. 27:3845-3853

Purpose:This was a multicenter, histology-agnostic, single-arm prospective phase II trial of therapeutic activity of everolimus, an oral mTORC1 inhibitor, in patients with advanced solid tumors that harbored TSC1/TSC2 or MTOR mutations.Patients and M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c7b5ee82e0c265db1a5c400c7c7ceb6
https://doi.org/10.1158/1078-0432.ccr-20-4548

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Akademický článek

Ex vivo expansion of human CD8+ T cells using autologous CD4+ T cell help.

Autor: Marcus O Butler, Osamu Imataki, Yoshihiro Yamashita, Makito Tanaka, Sascha Ansén, Alla Berezovskaya, Genita Metzler, Matthew I Milstein, Mary M Mooney, Andrew P Murray, Hiroyuki Mano, Lee M Nadler, Naoto Hirano

Publikováno v: PLoS ONE, Vol 7, Iss 1, p e30229 (2012)

Using in vivo mouse models, the mechanisms of CD4+ T cell help have been intensively investigated. However, a mechanistic analysis of human CD4+ T cell help is largely lacking. Our goal was to elucidate the mechanisms of human CD4+ T cell help of CD8

Externí odkaz: https://doaj.org/article/ecfdc6166ac84d34b817552f4d642e0d

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IL-21 Can Supplement Suboptimal Lck-Independent MAPK Activation in a STAT-3–Dependent Manner in Human CD8+ T Cells

Autor: Matthew I. Milstein, Naoto Hirano, Makito Tanaka, Osamu Imataki, Alla Berezovskaya, Sascha Ansén, Lee M. Nadler, Kiyotaka Kuzushima, Marcus O. Butler

Publikováno v: The Journal of Immunology. 188:1609-1619

Although both MHC class II/CD8α double-knockout and CD8β null mice show a defect in the development of MHC class I-restricted CD8+ T cells in the thymus, they possess low numbers of high-avidity peripheral CTL with limited clonality and are able to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e1d66e15a2267642c86cfe6279555c7
https://doi.org/10.4049/jimmunol.1003446

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A panel of human cell-based artificial APC enables the expansion of long-lived antigen-specific CD4+ T cells restricted by prevalent HLA-DR alleles

Autor: Makito Tanaka, Naoto Hirano, Marcus O. Butler, Alla Berezovskaya, Matthew I. Milstein, Sascha Ansén, Osamu Imataki, Lee M. Nadler, Genita Metzler, Mary M. Mooney

Publikováno v: International Immunology. 22:863-873

Many preclinical experiments have attested to the critical role of CD4(+) T cell help in CD8(+) cytotoxic T lymphocyte (CTL)-mediated immunity. Recent clinical trials have demonstrated that reinfusion of CD4(+) T cells can induce responses in infecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a876f1f4eab29f030d36e5b6467befc8
https://doi.org/10.1093/intimm/dxq440

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Establishment of antitumor memory in humans using in vitro-educated CD8+ T cells

Publikováno v: Science translational medicine. 3(80)

While advanced stage melanoma patients have a median survival of less than a year, adoptive T cell therapy can induce durable clinical responses in some patients. Successful adoptive T cell therapy to treat cancer requires engraftment of anti-tumor T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f0ec39a7533b1b0f5168955020a8e11
https://pubmed.ncbi.nlm.nih.gov/21525398

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Ex Vivo Expansion of Human CD8+ T Cells Using Autologous CD4+ T Cell Help

Autor: Makito Tanaka, Osamu Imataki, Genita Metzler, Marcus O. Butler, Sascha Ansén, Matthew I. Milstein, Lee M. Nadler, Mary M. Mooney, Hiroyuki Mano, Yoshihiro Yamashita, Naoto Hirano, Alla Berezovskaya, Andrew P. Murray

Publikováno v: PLoS ONE, Vol 7, Iss 1, p e30229 (2012)
PLoS ONE

Background Using in vivo mouse models, the mechanisms of CD4+ T cell help have been intensively investigated. However, a mechanistic analysis of human CD4+ T cell help is largely lacking. Our goal was to elucidate the mechanisms of human CD4+ T cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78907a219b5c4d2e417d8b8823c3705f
https://doi.org/10.1371/journal.pone.0030229

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