Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Matthew Hackbart"'
Autor:
Matthew Hackbart, Carolina B. López
Publikováno v:
mBio, Vol 15, Iss 10 (2024)
ABSTRACT Arenaviruses, a family of negative-sense RNA viruses spread by rodents, are a leading cause of severe hemorrhagic fever in humans. Due to a paucity of antivirals and vaccines for arenaviruses, there is a need to identify new mechanisms for i
Externí odkaz:
https://doaj.org/article/a56f6c7424344fa4861bc59700729b95
Publikováno v:
PLoS Biology, Vol 21, Iss 11, p e3002381 (2023)
Antiviral responses are often accompanied by translation inhibition and formation of stress granules (SGs) in infected cells. However, the triggers for these processes and their role during infection remain subjects of active investigation. Copy-back
Externí odkaz:
https://doaj.org/article/ad2bec942e104146b2af82efe650e303
Autor:
Susan L. Uprichard, Amornrat O’Brien, Monika Evdokimova, Cynthia L. Rowe, Cara Joyce, Matthew Hackbart, Yazmin E. Cruz-Pulido, Courtney A. Cohen, Michelle L. Rock, John M. Dye, Paul Kuehnert, Keersten M. Ricks, Marybeth Casper, Lori Linhart, Katrina Anderson, Laura Kirk, Jack A. Maggiore, Andrew S. Herbert, Nina M. Clark, Gail E. Reid, Susan C. Baker
Publikováno v:
Viruses, Vol 14, Iss 2, p 370 (2022)
Understanding the magnitude of responses to vaccination during the ongoing SARS-CoV-2 pandemic is essential for ultimate mitigation of the disease. Here, we describe a cohort of 102 subjects (70 COVID-19-naïve, 32 COVID-19-experienced) who received
Externí odkaz:
https://doaj.org/article/570717b62a8c4ca08e9497cd79588a89
SummaryDuring viral replication, RNA viruses produce non-standard viral genomes (nsVGs), including copy-back viral genomes (cbVGs) and deletion viral genomes (delVGs), that play a crucial role in regulating viral replication. The sequences of these n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13b876ffa77bc908731a827e559d4fd2
https://doi.org/10.1101/2023.04.25.537842
https://doi.org/10.1101/2023.04.25.537842
Publikováno v:
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
Significance Cells carry sensors that are primed to detect invading viruses. To avoid being recognized, coronaviruses express factors that interfere with host immune sensing pathways. Previous studies revealed that a coronavirus endoribonuclease (End
Autor:
Amornrat O'Brien, Timothy E. O'Brien, Brianna J. Close, Susan C. Baker, Mohsan Saeed, Matthew Hackbart, Da Yuan Chen
Publikováno v:
Virology
The need to stem the current outbreak of SARS-CoV-2 responsible for COVID-19 is driving the search for inhibitors that will block coronavirus replication and pathogenesis. The coronavirus 3C-like protease (3CLpro) encoded in the replicase polyprotein
Autor:
Susan C. Baker, Xufang Deng, Amornrat O'Brien, Aaron Volk, Matthew Hackbart, Yazmin E. Cruz-Pulido
Publikováno v:
Journal of Virology
Macrophages are an important cell type during coronavirus infections because they “notice” the infection and respond by inducing type I interferons, which limits virus replication. In turn, coronaviruses encode proteins that mitigate the cell’s
Autor:
Matthew Hackbart, Susan C. Baker, Andrew D. Mesecar, Robert C. Mettelman, Amornrat O'Brien, Kristina R. Kesely, Mackenzie E. Chapman, Yafang Chen, Xufang Deng, Anna M. Mielech
Publikováno v:
Journal of Virology
Coronaviruses employ a genetic economy by encoding multifunctional proteins that function in viral replication and also modify the host environment to disarm the innate immune response. The coronavirus papain-like protease 2 (PLP2) domain possesses p
Autor:
Matthew Hackbart, Leah J. Gruen, Nancy Innocentini, Stanford T. Shulman, Tetyana Bodnar, Kwang-Youn Kim, Kristine M. Wylie, Susan C. Baker, David Arrollo, Yazmin E. Cruz-Pulido, Anne H. Rowley
Publikováno v:
J Infect Dis
Background Kawasaki disease (KD) is the leading cause of childhood acquired heart disease in developed nations and can result in coronary artery aneurysms and death. Clinical and epidemiologic features implicate an infectious cause but specific antig
Autor:
Robert C. Mettelman, Xufang Deng, Amornrat O'Brien, Susan C. Baker, Anna M. Mielech, C. Cheng Kao, Guanghui Yi, Matthew Hackbart
Publikováno v:
Proceedings of the National Academy of Sciences
Coronaviruses are positive-sense RNA viruses that generate double-stranded RNA (dsRNA) intermediates during replication, yet evade detection by host innate immune sensors. Here we report that coronavirus nonstructural protein 15 (nsp15), an endoribon