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pro vyhledávání: '"Matthew H.Z. Frey"'
Autor:
Kristin D. Jeffrey, Ting-Lin B. Yang, Tatyana B. Kalynyak, James D. Johnson, Matthew H.Z. Frey, Yaryna Bychkivska, Dan S. Luciani, Arthur V. Sampaio, Kamila S. Gwiazda, T. Michael Underhill
Publikováno v:
Diabetes
OBJECTIVE—Endoplasmic reticulum (ER) stress has been implicated in the pathogenesis of diabetes, but the roles of specific ER Ca2+ release channels in the ER stress–associated apoptosis pathway remain unknown. Here, we examined the effects of sti
Autor:
Tatyana B. Kalynyak, Kristin D. Jeffrey, Dan S. Luciani, May Tee, Matthew H.Z. Frey, James D. Johnson, Vy Nguyen, Yaryna Bychkivska, Vardit Dror
Publikováno v:
The Journal of biological chemistry. 283(15)
Pancreatic beta-cell death is a critical event in type 1 diabetes, type 2 diabetes, and clinical islet transplantation. We have previously shown that prolonged block of ryanodine receptor (RyR)-gated release from intracellular Ca(2+) stores activates