Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Matthew H. Wong"'
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 18, Iss 7, Pp 425-435 (2016)
BACKGROUND: Extensive cross talk exists between PI3K/Akt/mTOR and mitogen-activated protein kinase (MAPK) pathways, and both are upregulated in pancreatic ductal adenocarcinoma (PDAC). Our previous study suggested that epidermal growth factor recepto
Externí odkaz:
https://doaj.org/article/0293d56686f54accaad482542a29b03c
Publikováno v:
Journal of Clinical Medicine, Vol 3, Iss 1, Pp 1-24 (2014)
Bone is the most common site of metastasis from breast cancer. Bone metastases from breast cancer are associated with skeletal-related events (SREs) including pathological fractures, spinal cord compression, surgery and radiotherapy to bone, as well
Externí odkaz:
https://doaj.org/article/868b3efa53e74666b754755b8c09ef83
Autor:
Ross C. Smith, Robert C. Baxter, Lyndsay Peters, Anthony J. Gill, Thomas J. Hugh, Jaswinder S. Samra, Nick Pavlakis, Sohel M. Julovi, Aiqun Xue, Matthew H. Wong
Purpose: PI3K–Akt is overexpressed in 50% to 70% of pancreatic ductal adenocarcinoma (PDAC). The hypothesis of this study is that PI3K and EGFR coinhibition may be effective in PDAC with upregulated PI3K–Akt signaling.Experimental Design: Multipl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7078f1d6724d8d188180ac5f712599a4
https://doi.org/10.1158/1078-0432.c.6524699
https://doi.org/10.1158/1078-0432.c.6524699
Autor:
Ross C. Smith, Robert C. Baxter, Lyndsay Peters, Anthony J. Gill, Thomas J. Hugh, Jaswinder S. Samra, Nick Pavlakis, Sohel M. Julovi, Aiqun Xue, Matthew H. Wong
Figure S5: Effect of single and dual blockade (DB) on cell proliferation (A, B) 3D contour maps for inhibition by ERL+AEW (A) and ERL+BYL (B). Synergy index (SI) was calculated by non-linear regression (PROC NLIN) using the Bliss synergy/antagonism f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5362093a86bf9ce15c7c3defde169fdf
https://doi.org/10.1158/1078-0432.22461143.v1
https://doi.org/10.1158/1078-0432.22461143.v1
Autor:
Ross C. Smith, Robert C. Baxter, Lyndsay Peters, Anthony J. Gill, Thomas J. Hugh, Jaswinder S. Samra, Nick Pavlakis, Sohel M. Julovi, Aiqun Xue, Matthew H. Wong
Table S1: IC50 values for inhibition of proliferation of (A) 5 PDAC cell lines and (B) 2 derived erlotinib-resistant (ER) cell lines, in response to inhibitors of EGFR (erlotinib, gefitinib), IGF1R (NVP-AEW541), MEK (PD-98059), PI3K (LY-294002), PI3K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::430e8492ed31bc58f775819b252b7a4f
https://doi.org/10.1158/1078-0432.22461125.v1
https://doi.org/10.1158/1078-0432.22461125.v1
Autor:
Ross C. Smith, Robert C. Baxter, Lyndsay Peters, Anthony J. Gill, Thomas J. Hugh, Jaswinder S. Samra, Nick Pavlakis, Sohel M. Julovi, Aiqun Xue, Matthew H. Wong
Supplementary Methods and Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c3f9636ac3dc8d3ea1e81e547684f66
https://doi.org/10.1158/1078-0432.22461128
https://doi.org/10.1158/1078-0432.22461128
Autor:
Jerzy P, Szaflarski, Elizabeth Martina, Bebin, Anne M, Comi, Anup D, Patel, Charuta, Joshi, Daniel, Checketts, Jules C, Beal, Linda C, Laux, Lisa M, De Boer, Matthew H, Wong, Merrick, Lopez, Orrin, Devinsky, Paul D, Lyons, Pilar Pichon, Zentil, Robert, Wechsler, Arie, Weinstock
Publikováno v:
Epilepsia
Summary Objective Since 2014, cannabidiol (CBD) has been administered to patients with treatment‐resistant epilepsies (TREs) in an ongoing expanded‐access program (EAP). We report interim results on the safety and efficacy of CBD in EAP patients
Publikováno v:
Computer Science - Research and Development. 26:285-295
The rate of failures in HPC systems continues to increase as the number of components comprising the systems increases. System logs are one of the valuable information sources that can be used to analyze system failures and their root causes. However
Autor:
Matthew H Wong, Nathan B Fountain
Publikováno v:
Therapy. 7:459-465
Lacosamide is a recently approved antiepileptic drug for the adjunctive treatment of partial-onset seizures in adults. It is a functionalized amino acid with a novel mechanism of action, possesses excellent oral absorption, has negligible protein bin
Autor:
Malcolm Buchanan, Julie A Miller, Arlene Mou, Emil D. Kurniawan, John P. Collins, Imogen Windle, Matthew H. Wong, Russell L. Gruen, G. Bruce Mann, Allison Rose
Publikováno v:
Annals of Surgical Oncology. 15:2542-2549
Breast-conserving surgery (BCS) requires clear surgical margins to minimize local recurrence. We sought to identify groups of patients at higher risk of involved margins who might benefit from preoperative counselling and/or more generous excision at