Zobrazeno 1 - 10 of 11 pro vyhledávání: '"Matthew H. Ward"'
1
Akademický článek
Severe metabolic alterations in liver cancer lead to ERK pathway activation and drug resistance
Autor: Zeribe Chike Nwosu, Weronika Piorońska, Nadia Battello, Andreas David Zimmer, Bedair Dewidar, Mei Han, Sharon Pereira, Biljana Blagojevic, Darko Castven, Verodia Charlestin, Pavlo Holenya, Julia Lochead, Carolina De La Torre, Norbert Gretz, Peter Sajjakulnukit, Li Zhang, Matthew H. Ward, Jens U. Marquardt, Marina Pasca di Magliano, Costas A. Lyssiotis, Jonathan Sleeman, Stefan Wölfl, Matthias Philip Ebert, Christoph Meyer, Ute Hofmann, Steven Dooley
Publikováno v: EBioMedicine, Vol 54, Iss , Pp - (2020)
Background: The extracellular signal-regulated kinase (ERK) pathway regulates cell growth, and is hyper-activated and associated with drug resistance in hepatocellular carcinoma (HCC). Metabolic pathways are profoundly dysregulated in HCC. Whether an
Externí odkaz: https://doaj.org/article/383d5f40c0a84df0afc5bf27b396bda2
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2
Akademický článek
Multiomic characterization of pancreatic cancer-associated macrophage polarization reveals deregulated metabolic programs driven by the GM-CSF–PI3K pathway
Autor: Seth Boyer, Ho-Joon Lee, Nina Steele, Li Zhang, Peter Sajjakulnukit, Anthony Andren, Matthew H Ward, Rima Singh, Venkatesha Basrur, Yaqing Zhang, Alexey I Nesvizhskii, Marina Pasca di Magliano, Christopher J Halbrook, Costas A Lyssiotis
Publikováno v: eLife, Vol 11 (2022)
The pancreatic ductal adenocarcinoma microenvironment is composed of a variety of cell types and marked by extensive fibrosis and inflammation. Tumor-associated macrophages (TAMs) are abundant, and they are important mediators of disease progression
Externí odkaz: https://doaj.org/article/5ab615422ad44ecba3e69a54697fdc06
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4
The tetraspanin transmembrane protein CD53 mediates dyslipidemia and integrates inflammatory and metabolic signaling in hepatocytes
Autor: Cassandra B. Higgins, Joshua A. Adams, Matthew H. Ward, Zev J. Greenberg, Małgorzata Milewska, Jiameng Sun, Yiming Zhang, Luana Chiquetto Paracatu, Qian Dong, Samuel Ballentine, Weikai Li, Ilona Wandzik, Laura G. Schuettpelz, Brian J. DeBosch
Publikováno v: The Journal of biological chemistry.
Tetraspanins are transmembrane signaling and pro-inflammatory proteins. Prior work demonstrates the tetraspanin, CD53/TSPAN25/MOX44 mediates B-cell development, and lymphocyte homing and migration to lymph nodes, and is implicated in various inflamma
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::912b1dbb8ee4d0be1e16b5b0b93f88a9
https://pubmed.ncbi.nlm.nih.gov/36581203
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5
Multiomic characterization of pancreatic cancer-associated macrophage polarization reveals deregulated metabolic programs driven by the GM-CSF-PI3K pathway
Autor: Ho-Joon Lee, Seth Boyer, Nina Steele, Li Zhang, Peter Sajjakulnukit, Anthony Andren, Matthew H Ward, Rima Singh, Venkatesha Basrur, Yaqing Zhang, Alexey I Nesvizhskii, Marina Pasca di Magliano, Christopher J Halbrook, Costas A Lyssiotis
Publikováno v: eLife, Vol 11 (2022)
The pancreatic ductal adenocarcinoma microenvironment is composed of a variety of cell types and marked by extensive fibrosis and inflammation. Tumor-associated macrophages (TAMs) are abundant, and they are important mediators of disease progression
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::247a1a8d9054da2431c706fa9dee907b
https://escholarship.org/uc/item/7799k8jb
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