Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Matthew H. Katcher"'
Autor:
Matthew H. Katcher, Timothy F. Jamison
Publikováno v:
PMC
Shortly after the initial isolation of marine ladder polyether natural products, biomimetic epoxide-opening cascade reactions were proposed as an efficient strategy for the synthesis of these compounds. However, difficulties in assembling the cascade
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fd2b7eef9b8a2d5ed4f238efec0298f
https://doi.org/10.1016/j.tet.2018.01.039
https://doi.org/10.1016/j.tet.2018.01.039
Publikováno v:
Nature chemistry
Although carbon dioxide (CO2) is highly abundant, its low reactivity has limited its use in chemical synthesis. In particular, methods for carbon-carbon bond formation generally rely on two-electron mechanisms for CO2 activation and require highly ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a80efcdc630a40501b4e0a6cb2f4fabf
https://doi.org/10.1038/nchem.2690
https://doi.org/10.1038/nchem.2690
Autor:
Lin Xu, Grace Chan, Melaney Bouthillette, Craig Rosenstein, Sathyajith E. Kumarasinghe, C. Gary Marshall, Tony Siu, Anjili Mathur, Alan B. Northrup, Michael D. Altman, Christopher J. Dinsmore, Matthew H. Katcher, Catherine White, Eric Bachman, Jonathan R. Young
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:1466-1471
This communication discusses the discovery of novel reverse tricyclic pyridones as inhibitors of Janus kinase 2 (JAK2). By using a kinase cross screening approach coupled with molecular modeling, a unique inhibitor–water interaction was discovered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::019b05288f9a265bdc23c81724b809ed
https://doi.org/10.1016/j.bmcl.2014.02.011
https://doi.org/10.1016/j.bmcl.2014.02.011
Publikováno v:
Organometallics. 33:2121-2133
A computational and experimental approach was employed to study the mechanism of the palladium(0)-catalyzed fluorination of allylic chlorides with AgF as fluoride source. Our findings indicate that an allylpalladium fluoride is a key intermediate nec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b778da56f0243d3996e15d307d67cc15
https://doi.org/10.1021/om401240p
https://doi.org/10.1021/om401240p
Autor:
Michael D. Altman, Christopher J. Dinsmore, John F. Reilly, Jonathan R. Young, Chaomin Li, Sangita B. Patel, Deborah Walker, Craig Rosenstein, David Joseph Guerin, Timothy Allison, Harold Hatch, Stephen M. Soisson, Sujal V. Deshmukh, Bart Lutterbach, Bo Sheng Pan, Danielle Falcone, Michael H. Reutershan, Keith W. Rickert, Matthew H. Katcher, Wei Lu, Melissa Chenard, Kevin J. Wilson, Alan B. Northrup, Alexander A. Szewczak, Matthew H. Daniels
Publikováno v:
Journal of Medicinal Chemistry. 56:2294-2310
This report documents the first example of a specific inhibitor of protein kinases with preferential binding to the activated kinase conformation: 5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one 11r (MK-8033), a dual c-Met/Ron inhibitor under investigati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1117137a3ef810ac7f93b40f98ec667e
https://doi.org/10.1021/jm301619u
https://doi.org/10.1021/jm301619u
Publikováno v:
Journal of the American Chemical Society. 133:15902-15905
This report describes the Pd(0)-catalyzed fluorination of linear allylic chlorides and bromides, yielding branched allylic fluorides in high selectivity. Many of the significant synthetic limitations previously associated with the preparation of thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::091e4968a6824db5b373c994095a5f1b
https://doi.org/10.1021/ja206960k
https://doi.org/10.1021/ja206960k
Autor:
Abigail G. Doyle, Matthew H. Katcher
Publikováno v:
Journal of the American Chemical Society. 132:17402-17404
The enantioselective fluorination of readily available cyclic allylic chlorides with AgF has been accomplished using a Pd(0) catalyst and Trost bisphosphine ligand. The reactions proceed with unprecedented ease of operation for Pd-mediated nucleophil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::195d277441d50f9eb7fea5fe40a9259f
https://doi.org/10.1021/ja109120n
https://doi.org/10.1021/ja109120n
Autor:
Alan B, Northrup, Matthew H, Katcher, Michael D, Altman, Melissa, Chenard, Matthew H, Daniels, Sujal V, Deshmukh, Danielle, Falcone, David J, Guerin, Harold, Hatch, Chaomin, Li, Wei, Lu, Bart, Lutterbach, Timothy J, Allison, Sangita B, Patel, John F, Reilly, Michael, Reutershan, Keith W, Rickert, Craig, Rosenstein, Stephen M, Soisson, Alexander A, Szewczak, Deborah, Walker, Kevin, Wilson, Jonathan R, Young, Bo-Sheng, Pan, Christopher J, Dinsmore
Publikováno v:
Journal of medicinal chemistry. 56(6)
This report documents the first example of a specific inhibitor of protein kinases with preferential binding to the activated kinase conformation: 5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one 11r (MK-8033), a dual c-Met/Ron inhibitor under investigati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4116662dcbbe55aab9b82313c0024c89
https://pubmed.ncbi.nlm.nih.gov/23379595
https://pubmed.ncbi.nlm.nih.gov/23379595
Publikováno v:
ChemInform. 43
Linear allylic chlorides or bromides are fluorinated with high selectivity for the branched products in the presence of chiral bisphosphine-ligated palladium catalysts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9adf0fb4540f2725b731939afb23fd73
https://doi.org/10.1002/chin.201212022
https://doi.org/10.1002/chin.201212022
Autor:
Matthew H. Katcher, Abigail G. Doyle
Publikováno v:
ChemInform. 42
The enantioselective fluorination of readily available cyclic allylic chlorides with AgF has been accomplished using a Pd(0) catalyst and Trost bisphosphine ligand. The reactions proceed with unprecedented ease of operation for Pd-mediated nucleophil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65eaec69a398264672e916cee6b96d6c
https://doi.org/10.1002/chin.201119035
https://doi.org/10.1002/chin.201119035