Zobrazeno 1 - 10
of 135
pro vyhledávání: '"Matthew H Todd"'
Autor:
Wilson Lim, Youri Melse, Mickey Konings, Hung Phat Duong, Kimberly Eadie, Benoît Laleu, Benjamin Perry, Matthew H Todd, Jean-Robert Ioset, Wendy W J van de Sande
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 12, Iss 4, p e0006437 (2018)
Eumycetoma is a chronic infectious disease characterized by a large subcutaneous mass, often caused by the fungus Madurella mycetomatis. A combination of surgery and prolonged medication is needed to treat this infection with a success rate of only 3
Externí odkaz:
https://doaj.org/article/bc3b4ad960864546b8afa606fed0e6cb
Autor:
Manica Balasegaram, Peter Kolb, John McKew, Jaykumar Menon, Piero Olliaro, Tomasz Sablinski, Zakir Thomas, Matthew H Todd, Els Torreele, John Wilbanks
Publikováno v:
PLoS Medicine, Vol 14, Iss 4, p e1002276 (2017)
In an Essay, Matthew Todd and colleagues discuss an open source approach to drug development.
Externí odkaz:
https://doaj.org/article/4d75cbd71468428f9a1445ae88cccd98
Autor:
Mingfeng Yu, Sandra Ast, Qun Yu, Anthony T S Lo, Roman Flehr, Matthew H Todd, Peter J Rutledge
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e100761 (2014)
Ligands incorporating a tetraazamacrocycle receptor, a 'click'-derived triazole and a 1,8-naphthalimide fluorophore have proven utility as probes for metal ions. Three new cyclam-based molecular probes are reported, in which a piperidinyl group has b
Externí odkaz:
https://doaj.org/article/e3b18a6eb8bf4b8399f456769cf0a5ef
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e111782 (2014)
Tuberculosis afflicts an estimated 2 billion people worldwide and causes 1.3 million deaths annually. Chemotherapeutic solutions rely on drugs developed many years ago, with only one new therapeutic having been approved in the last 40 years. Given th
Externí odkaz:
https://doaj.org/article/32981c099fc943539bc32dd3ef2955d7
Autor:
Stanley C. Xie, Yinuo Wang, Craig J. Morton, Riley D. Metcalfe, Con Dogovski, Charisse Flerida A. Pasaje, Elyse Dunn, Madeline R. Luth, Krittikorn Kumpornsin, Eva S. Istvan, Joon Sung Park, Kate J. Fairhurst, Nutpakal Ketprasit, Tomas Yeo, Okan Yildirim, Mathamsanqa N. Bhebhe, Dana M. Klug, Peter J. Rutledge, Luiz C. Godoy, Sumanta Dey, Mariana Laureano De Souza, Jair L. Siqueira-Neto, Yawei Du, Tanya Puhalovich, Mona Amini, Gerry Shami, Duangkamon Loesbanluechai, Shuai Nie, Nicholas Williamson, Gouranga P. Jana, Bikash C. Maity, Patrick Thomson, Thomas Foley, Derek S. Tan, Jacquin C. Niles, Byung Woo Han, Daniel E. Goldberg, Jeremy Burrows, David A. Fidock, Marcus C. S. Lee, Elizabeth A. Winzeler, Michael D. W. Griffin, Matthew H. Todd, Leann Tilley
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Malaria poses an enormous threat to human health. With ever increasing resistance to currently deployed drugs, breakthrough compounds with novel mechanisms of action are urgently needed. Here, we explore pyrimidine-based sulfonamides as a ne
Externí odkaz:
https://doaj.org/article/74ceb3d2587846d1a75544faccf7d8f1
Autor:
Hassan Masum, Aarthi Rao, Benjamin M Good, Matthew H Todd, Aled M Edwards, Leslie Chan, Barry A Bunin, Andrew I Su, Zakir Thomas, Philip E Bourne
Publikováno v:
PLoS Computational Biology, Vol 9, Iss 9, p e1003244 (2013)
Externí odkaz:
https://doaj.org/article/c9056ebb0aed481caca10f22cb490625
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47224 (2012)
We compare the results from the oxidation of two unusual "enediamide" motifs (3,4-dihydropyrazin-2(1H)-ones), where a double bond is flanked by two amides. In one case the oxidation led to a ring-opened product arising from the cleavage of the double
Externí odkaz:
https://doaj.org/article/9d32fd1805d045e28f1a62bfaff0e314
Autor:
Michael Woelfle, Jean-Paul Seerden, Jesse de Gooijer, Kees Pouwer, Piero Olliaro, Matthew H Todd
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 5, Iss 9, p e1260 (2011)
BACKGROUND:Praziquantel remains the drug of choice for the worldwide treatment and control of schistosomiasis. The drug is synthesized and administered as a racemate. Use of the pure active enantiomer would be desirable since the inactive enantiomer
Externí odkaz:
https://doaj.org/article/a5bed4afb49441778740fdeba107627c
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e17446 (2011)
Cyclam was attached to 1-, 2- and 3-pyrrole lexitropsins for the first time through a synthetically facile copper-catalyzed "click" reaction. The corresponding copper and zinc complexes were synthesized and characterized. The ligand and its complexes
Externí odkaz:
https://doaj.org/article/960d9000aebd4e979253594fa32617f3
Autor:
Leticia Ortí, Rodrigo J Carbajo, Ursula Pieper, Narayanan Eswar, Stephen M Maurer, Arti K Rai, Ginger Taylor, Matthew H Todd, Antonio Pineda-Lucena, Andrej Sali, Marc A Marti-Renom
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 3, Iss 4, p e418 (2009)
Conventional patent-based drug development incentives work badly for the developing world, where commercial markets are usually small to non-existent. For this reason, the past decade has seen extensive experimentation with alternative R&D institutio
Externí odkaz:
https://doaj.org/article/d675c07281044f6195bfb6c6c5def459