Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Matthew H, Plant"'
Publikováno v:
BBA Advances, Vol 1, Iss, Pp 100022-(2021)
BBA Adv
BBA Adv
The fundamental importance of membrane protein (MP) targets in central biological and cellular events has driven a marked increase in the use of membrane mimetics for exploring these proteins as therapeutic targets. The main challenge associated with
Autor:
Loren Berry, Hakan Gunaydin, Nagasree Chakka, Jeffrey R. Simard, Angel Guzman-Perez, Matthew H. Plant, Erin F. DiMauro, Kristin L. Andrews, Liyue Huang, Jacinthe Gingras, Howard Bregman
Publikováno v:
European Journal of Medicinal Chemistry. 137:63-75
Glycine receptors (GlyRs) are pentameric glycine-gated chloride ion channels that are enriched in the brainstem and spinal cord where they have been demonstrated to play a role in central nervous system (CNS) inhibition. Herein we describe two novel
Autor:
Shuyan Yi, Sonya G. Lehto, Stefan I. McDonough, Klaus Michelsen, Erin F. DiMauro, Hao Chen, Maosheng Zhang, Stephen Schneider, Shawn Ayube, Jason A. Luther, Matthew H. Plant, Xin Huang, David J. Matson, Jeffrey R. Simard, Howard Bregman, Jacinthe Gingras, Paul L. Shaffer, Yohannes Teffera
Publikováno v:
Nature Structural & Molecular Biology. 24:108-113
Current therapies to treat persistent pain and neuropathic pain are limited by poor efficacy, side effects and risk of addiction. Here, we present a novel class of potent selective, central nervous system (CNS)-penetrant potentiators of glycine recep
Autor:
Shawn Ayube, Hao Chen, Yohannes Teffera, Jacinthe Gingras, Paul L. Shaffer, Paul Krolikowski, Angel Guzman-Perez, Kristin L. Andrews, Hakan Gunaydin, Richard Thomas Lewis, Klaus Michelsen, Jiali Hu, Liyue Huang, Sonya G. Lehto, Pamela Pegman, Erin F. DiMauro, Howard Bregman, Shuyan Yi, Xin Huang, Maosheng Zhang, Matthew H. Plant, Jeffrey R. Simard
Publikováno v:
Journal of medicinal chemistry. 60(3)
Current pain therapeutics suffer from undesirable psychotropic and sedative side effects, as well as abuse potential. Glycine receptors (GlyRs) are inhibitory ligand-gated ion channels expressed in nerves of the spinal dorsal horn, where their activa
Publikováno v:
ASSAY and Drug Development Technologies. 11:152-162
The methylation state of lysine residues within histone H3 is a major determinant of active and inactive regions of the genome. Enhancer of Zeste homolog 2 (EZH2) is a histone lysine methyltransferase that is part of the polycomb repressive complex 2
Publikováno v:
Analytical Biochemistry. 419:217-227
Posttranslational modifications on the N terminus of histone H3 act in a combinatorial fashion to control epigenetic responses to extracellular stimuli. Lysine-specific demethylase-1 (LSD1) represents an emerging epigenetic target class for the disco
Autor:
Christiaan J. M. Saris, Lu Min Wong, Brad Herberich, Qiurong Liu, Bradley Henkle, Matthew R. Lee, Ryan Wurz, Liping H. Pettus, Christopher Mohr, Sharon X. Mu, Faye Hsieh, Matthew H. Plant, Samer Chmait, Helen J. McBride, Shimin Xu, Andrew Tasker, Lisa Sherman
Publikováno v:
Journal of Medicinal Chemistry. 53:2973-2985
The p38α mitogen-activated protein (MAP) kinase is a central signaling molecule in many proinflammatory pathways, regulating the cellular response to a multitude of external stimuli including heat, ultraviolet radiation, osmotic shock, and a variety
Autor:
David Powers, Guo-Qiang Cao, Scott Middleton, Lisa Sherman, Kelvin Sham, Dawei Zhang, Partha P. Chakrabarti, Faye Hsieh, Andrew Tasker, Yanyan Tudor, Bradley Henkle, Shimin Xu, Lu Min Wong, Ryan Wurz, Liping H. Pettus, Matthew R. Lee, Robert M. Rzasa, Violeta Yu, Christiaan J. M. Saris, Matthew H. Plant, Rashid Syed
Publikováno v:
Journal of Medicinal Chemistry. 51:6280-6292
The p38 mitogen-activated protein kinase (MAPK) is a central signaling molecule in many proinflammatory pathways, regulating the cellular response to a multitude of external stimuli including heat, ultraviolet radiation, osmotic shock, and a variety
Autor:
Thomas M. Dillon, Yaoqing Diana Liu, Matthew H. Plant, Songpon Deechongkit, Yu Li, Chris Vezina, Brad Henkle, Brian Varnum, Gregory C. Flynn, Douglas Rehder, Pavel V. Bondarenko, Margaret Speed Ricci, Jette Wypych, Alain Balland
Publikováno v:
Journal of Biological Chemistry. 283:16206-16215
In the accompanying report ( Wypych, J., Li, M., Guo, A., Zhang, Z., Martinez, T., Allen, M. J., Fodor, S., Kelner, D. N., Flynn, G. C., Liu, Y. D., Bondarenko, P. V., Ricci, M. S., Dillon, T. M., and Balland, A. (2008) J. Biol. Chem. 283, 16194-1620
Autor:
Ning Chen, Andrea Itano, Randall W. Hungate, Ryan White, Yang Xu, Matthew H. Plant, Yanyan Tudor, Yen Nguyen, Roxanne Kunz, Perry M. Novak, Kristin Meagher, Essa Hu, Jason Brooks Human, Shaun Flynn, Gordon Ng, Xuxia Zhang, Violeta Yu, Roland Burli, Douglas A. Whittington, Andrew Tasker
Publikováno v:
Journal of Medicinal Chemistry. 51:3065-3068
Inhibition of c-Kit has the potential to treat mast cell associated fibrotic diseases. We report the discovery of several aminoquinazoline pyridones that are potent inhibitors of c-Kit with greater than 200-fold selectivity against KDR, p38, Lck, and