Automated optimization of the solubility of a hyper-stable α-amylase

Autor: Montader Ali, Matthew Greenig, Marc Oeller, Misha Atkinson, Xing Xu, Pietro Sormanni

Publikováno v: Open Biology, Vol 14, Iss 5 (2024)

Most successes in computational protein engineering to date have focused on enhancing one biophysical trait, while multi-trait optimization remains a challenge. Different biophysical properties are often conflicting, as mutations that improve one ten

Externí odkaz: https://doaj.org/article/8ffedd5c6a95449f880744967c3da0b7

Determinants of pre-vaccination antibody responses to SARS-CoV-2: a population-based longitudinal study (COVIDENCE UK)

Autor: Mohammad Talaei, Sian Faustini, Hayley Holt, David A. Jolliffe, Giulia Vivaldi, Matthew Greenig, Natalia Perdek, Sheena Maltby, Carola M. Bigogno, Jane Symons, Gwyneth A. Davies, Ronan A. Lyons, Christopher J. Griffiths, Frank Kee, Aziz Sheikh, Alex G. Richter, Seif O. Shaheen, Adrian R. Martineau

Publikováno v: BMC Medicine, Vol 20, Iss 1, Pp 1-18 (2022)

Abstract Background Prospective population-based studies investigating multiple determinants of pre-vaccination antibody responses to SARS-CoV-2 are lacking. Methods We did a prospective population-based study in SARS-CoV-2 vaccine-naive UK adults re

Externí odkaz: https://doaj.org/article/b7da12e1b2c54b6dafee73e239876df6

Determinants of Antibody Responses to SARS-CoV-2 Vaccines: Population-Based Longitudinal Study (COVIDENCE UK)

Autor: David A. Jolliffe, Sian E. Faustini, Hayley Holt, Natalia Perdek, Sheena Maltby, Mohammad Talaei, Matthew Greenig, Giulia Vivaldi, Florence Tydeman, Jane Symons, Gwyneth A. Davies, Ronan A. Lyons, Christopher J. Griffiths, Frank Kee, Aziz Sheikh, Seif O. Shaheen, Alex G. Richter, Adrian R. Martineau

Publikováno v: Vaccines, Vol 10, Iss 10, p 1601 (2022)

Antibody responses to SARS-CoV-2 vaccines vary for reasons that remain poorly understood. A range of sociodemographic, behavioural, clinical, pharmacologic and nutritional factors could explain these differences. To investigate this hypothesis, we te

Externí odkaz: https://doaj.org/article/6ecab6ed88594c469e61463d03cf769b

HERVs, immunity, and autoimmunity: understanding the connection

Autor: Matthew Greenig

Publikováno v: PeerJ, Vol 7, p e6711 (2019)

Since their discovery in the 1960s, further investigation into endogenous retroviruses (ERVs) has challenged the conventional view of viral sequences as exclusively parasitic elements. Once presumed to be a group of passive genetic relics, it is beco

Externí odkaz: https://doaj.org/article/0b0b5a99b7954250b919d472fabe5c82

Effect of a test-and-treat approach to vitamin D supplementation on risk of all cause acute respiratory tract infection and covid-19: phase 3 randomised controlled trial (CORONAVIT)

Autor: David A Jolliffe, Hayley Holt, Matthew Greenig, Mohammad Talaei, Natalia Perdek, Paul Pfeffer, Giulia Vivaldi, Sheena Maltby, Jane Symons, Nicola L Barlow, Alexa Normandale, Rajvinder Garcha, Alex G Richter, Sian E Faustini, Christopher Orton, David Ford, Ronan A Lyons, Gwyneth A Davies, Frank Kee, Christopher J Griffiths, John Norrie, Aziz Sheikh, Seif O Shaheen, Clare Relton, Adrian R Martineau

Publikováno v: Jolliffe, D A, Holt, H, Greenig, M, Talaei, M, Perdek, N, Pfeffer, P, Vivaldi, G, Maltby, S, Symons, J, Barlow, N L, Normandale, A, Garcha, R, Richter, A G, Faustini, S E, Orton, C, Ford, D, Lyons, R A, Davies, G A, Kee, F, Griffiths, C J, Norrie, J, Sheikh, A, Shaheen, S O, Relton, C & Martineau, A R 2022, ' Effect of a test-and-treat approach to vitamin D supplementation on risk of all cause acute respiratory tract infection and covid-19 : phase 3 randomised controlled trial (CORONAVIT) ', BMJ (Clinical research ed.), vol. 378, 071230, pp. e071230 . https://doi.org/10.1136/bmj-2022-071230
Jolliffe, D A, Holt, H, Greenig, M, Talaei, M, Perdek, N, Pfeffer, P, Vivaldi, G, Maltby, S, Symons, J, Barlow, N L, Normandale, A, Garcha, R, Richter, A G, Faustini, S E, Orton, C, Ford, D, Lyons, R A, Davies, G A, Kee, F, Griffiths, C J, Norrie, J, Sheikh, A, Shaheen, S O, Relton, C & Martineau, A R 2022, ' Effect of a test-and-treat approach to vitamin D supplementation on risk of all cause acute respiratory tract infection and covid-19: phase 3 randomised controlled trial (CORONAVIT) ', BMJ, vol. 378, e071230 . https://doi.org/10.1136/bmj-2022-071230

ObjectiveTo determine the effect of population level implementation of a test-and-treat approach to correction of suboptimal vitamin D status (25-hydroxyvitamin D (25(OH)D) DesignPhase 3 open label randomised controlled trial.SettingUnited Kingdom.Pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43dad49bfbd33c1034ec6e1d3c8afe3e
https://pubmed.ncbi.nlm.nih.gov/36215226