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Autor:
Matthew Garvie, Philippe Collas, Joanna Voon, Linda Hii, Maheshi Udugama, Jeffrey R. Mann, Benjamin Vinod, Lyn Chan, Andrew Garvie, Lee H. Wong
Publikováno v:
Cancer Research. 81:2065-2065
Alternative Lengthening of Telomeres (ALT) is a telomere maintenance pathway utilized in 15% of cancers. ALT cancers are strongly associated with inactivating mutations in ATRX; yet ATRX knockout (KO) alone is insufficient to trigger ALT, suggesting