Zobrazeno 1 - 10
of 367
pro vyhledávání: '"Matthew G. Vander Heiden"'
Autor:
Ting Dong, Guangan Hu, Zhongqi Fan, Huirui Wang, Yinghui Gao, Sisi Wang, Hao Xu, Michael B. Yaffe, Matthew G. Vander Heiden, Guoyue Lv, Jianzhu Chen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Kupffer cells are liver resident macrophages and play critical role in fatty liver disease, yet the underlying mechanisms remain unclear. Here, we show that activation of G-protein coupled receptor 3 (GPR3) in Kupffer cells stimulates glycol
Externí odkaz:
https://doaj.org/article/83d25661a3af40cb9b261bb33f972632
Autor:
Azucena Ramos, Catherine E. Koch, Yunpeng Liu-Lupo, Riley D. Hellinger, Taeyoon Kyung, Keene L. Abbott, Julia Fröse, Daniel Goulet, Khloe S. Gordon, Keith P. Eidell, Paul Leclerc, Charles A. Whittaker, Rebecca C. Larson, Audrey J. Muscato, Kathleen B. Yates, Juan Dubrot, John G. Doench, Aviv Regev, Matthew G. Vander Heiden, Marcela V. Maus, Robert T. Manguso, Michael E. Birnbaum, Michael T. Hemann
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract CAR-T therapy is a promising, novel treatment modality for B-cell malignancies and yet many patients relapse through a variety of means, including loss of CAR-T cells and antigen escape. To investigate leukemia-intrinsic CAR-T resistance mec
Externí odkaz:
https://doaj.org/article/6711e44bcbe14aeaa34f0e56893dd8c0
Autor:
Daniel R. Schmidt, Iva Monique T. Gramatikov, Allison Sheen, Christopher L. Williams, Martina Hurwitz, Laura E. Dodge, Edward Holupka, W. S. Kiger, Milton R. Cornwall-Brady, Wei Huang, Howard H. Mak, Kathleen S Cormier, Charlene Condon, K. Dane Wittrup, Ömer H. Yilmaz, Mary Ann Stevenson, Julian D. Down, Scott R. Floyd, Jatin Roper, Matthew G. Vander Heiden
Publikováno v:
Communications Medicine, Vol 3, Iss 1, Pp 1-20 (2023)
Abstract Background Genetically engineered mouse models (GEMMs) of cancer are powerful tools to study mechanisms of disease progression and therapy response, yet little is known about how these models respond to multimodality therapy used in patients
Externí odkaz:
https://doaj.org/article/e2abc75b55aa4454ae9d147cefaedee3
Autor:
Ana Babic, Michael H. Rosenthal, Tilak K. Sundaresan, Natalia Khalaf, Valerie Lee, Lauren K. Brais, Maureen Loftus, Leah Caplan, Sarah Denning, Anamol Gurung, Joanna Harrod, Khoschy Schawkat, Chen Yuan, Qiao-Li Wang, Alice A. Lee, Leah H. Biller, Matthew B. Yurgelun, Kimmie Ng, Jonathan A. Nowak, Andrew J. Aguirre, Sangeeta N. Bhatia, Matthew G. Vander Heiden, Stephen K. Van Den Eeden, Bette J. Caan, Brian M. Wolpin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-9 (2023)
Abstract Patients with pancreatic cancer commonly develop weight loss and muscle wasting. Whether adipose tissue and skeletal muscle losses begin before diagnosis and the potential utility of such losses for earlier cancer detection are not well unde
Externí odkaz:
https://doaj.org/article/cdfd07dd22ed47b9aca3132200d8cb87
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113539- (2023)
Summary: Amino acids are required for cell growth and proliferation, but it remains unclear when and how amino acid availability impinges on the proliferation-quiescence decision. Here, we used time-lapse microscopy and single-cell tracking of cyclin
Externí odkaz:
https://doaj.org/article/deeb890350914ea4867c7f7a7bf40353
Autor:
Reuben Franklin, Yiming Guo, Shiyang He, Meijuan Chen, Fei Ji, Xinyue Zhou, David Frankhouser, Brian T. Do, Carmen Chiem, Mihyun Jang, M. Andres Blanco, Matthew G. Vander Heiden, Russell C. Rockne, Maria Ninova, David B. Sykes, Konrad Hochedlinger, Rui Lu, Ruslan I. Sadreyev, Jernej Murn, Andrew Volk, Sihem Cheloufi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Cell fate commitment involves transcription factor activity and changes in chromatin architecture. Here the authors show that CAF-1 maintains lineage fidelity by controlling chromatin accessibility at specific sites; suppressing CAF-1 triggers differ
Externí odkaz:
https://doaj.org/article/92b1277f52324a2d9ee446b86d5f55dd
Autor:
Chenxi Tian, Ying Huang, Karl R. Clauser, Steffen Rickelt, Allison N. Lau, Steven A. Carr, Matthew G. Vander Heiden, Richard O. Hynes
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Pancreatic ductal adenocarcinoma has a collagen-rich dense extracellular matrix that promotes malignancy of cancer cells. Here, the authors show that fibrillar collagen that is cancer-cell-derived, but not stroma-derived, selectively restrains tumor
Externí odkaz:
https://doaj.org/article/cbed56b38aff4504b548e616901c398d
Autor:
H. Furkan Alkan, Paul W. Vesely, Hubert Hackl, Johannes Foßelteder, Daniel R. Schmidt, Matthew G. Vander Heiden, Martin Pichler, Gerald Hoefler, Juliane G. Bogner-Strauss
Publikováno v:
Cancer & Metabolism, Vol 8, Iss 1, Pp 1-13 (2020)
Abstract Background Aspartate biosynthesis and its delivery to the cytosol can be crucial for tumor growth in vivo. However, the impact of intracellular aspartate levels on metastasis has not been studied. We previously described that loss-of-asparta
Externí odkaz:
https://doaj.org/article/dcdb3f2427ac497ea73bb305ac44489a
Autor:
Joon Ho Kang, Georgios Katsikis, Zhaoqi Li, Kiera M. Sapp, Max A. Stockslager, Daniel Lim, Matthew G. Vander Heiden, Michael B. Yaffe, Scott R. Manalis, Teemu P. Miettinen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
ATP drives most cellular processes, although ATP production and consumption levels during mitosis remain unreported. Here, the authors combine metabolic measurements and modeling to quantify ATP levels and synthesis dynamics, revealing that ATP synth
Externí odkaz:
https://doaj.org/article/7d36fb2261454301970a2d8ba6a0530b
Autor:
Yingzhong Li, Nikola A. Ivica, Ting Dong, Dimitrios P. Papageorgiou, Yanpu He, Douglas R. Brown, Marianna Kleyman, Guangan Hu, Walter W. Chen, Lucas B. Sullivan, Amanda Del Rosario, Paula T. Hammond, Matthew G. Vander Heiden, Jianzhu Chen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Mitochondria maintain a balance between thermogenesis and ATP synthesis, but how this is coordinated is largely unknown. Here, the authors show that MFSD7C coordinates ATP synthesis and thermogenesis in response to heme by directly binding to electro
Externí odkaz:
https://doaj.org/article/f4b39f9789c94baca207b22daeaf19cc