Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Matthew G. LaPorte"'
Autor:
Purbasha Nandi, Kira DeVore, Feng Wang, Shan Li, Joel D. Walker, Thanh Tung Truong, Matthew G. LaPorte, Peter Wipf, Heidi Schlager, John McCleerey, William Paquette, Rod Carlo A. Columbres, Taiping Gan, Yu-Ping Poh, Petra Fromme, Andrew J. Flint, Mark Wolf, Donna M. Huryn, Tsui-Fen Chou, Po-Lin Chiu
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Human p97 ATPase is crucial in various cellular processes, making it a target for inhibitors to treat cancers, neurological, and infectious diseases. Triazole allosteric p97 inhibitors have been demonstrated to match the efficacy of CB-5083,
Externí odkaz:
https://doaj.org/article/7172d10d2bd14f27b0b2ec9522138128
Autor:
Malabika Sen, Audrey Kindsfather, Ludmila Danilova, Feng Zhang, Raffaele Colombo, Matthew G. LaPorte, Brenda F. Kurland, Donna M. Huryn, Peter Wipf, James G. Herman
Publikováno v:
Epigenetics, Vol 15, Iss 6-7, Pp 604-617 (2020)
Signal Transducers and Activators of Transcription-3 (STAT3), a potent oncogenic transcription factor, is constitutively activated in lung cancer, but mutations in pathway genes are infrequent. Protein Tyrosine Phosphatase Receptor-T (PTPRT) is an en
Externí odkaz:
https://doaj.org/article/333860db35804967959dcc5164891d1b
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 8, Iss 1, Pp 1048-1058 (2012)
The synthesis of a library of tetrahydro-β-carboline-containing compounds in milligram quantities is described. Among the unique heterocyclic frameworks are twelve tetrahydroindolizinoindoles, six tetrahydrocyclobutanindoloquinolizinones and three t
Externí odkaz:
https://doaj.org/article/e2e91948709e45f8a42168178499e068
Publikováno v:
Molecules, Vol 16, Iss 5, Pp 3648-3662 (2011)
Eighteen (2RS,6RS)-2-(4-methoxyphenyl)-6-(substituted ethyl)dihydro-2H-pyran-4(3H)ones were synthesized via a DDQ-mediated oxidative carbon-hydrogen bond activation reaction. Fourteen of these tetrahydropyrans were substituted with triazoles readily
Externí odkaz:
https://doaj.org/article/88d4fe88b25c421ebcc328cfb63e2439
Autor:
Srinivas K. Chunduru, Mark A. McKinlay, Yigong Shi, David Weng, Martin A. Graham, Matthew D. Alexander, Thomas Haimowitz, Yu-Hua Lee, Pavan K. Tirunahari, Mukta S. Hendi, Yijun Deng, Susan R. Rippin, Matthew G. LaPorte, Gurpreet S. Kapoor, Martin E. Seipel, Guangyao Yu, Stephen M. Condon, Eric M. Neiman, Jennifer M. Burns, Yasuhiro Mitsuuchi, Christopher A. Benetatos
The acquisition of apoptosis resistance is a fundamental event in cancer development. Among the mechanisms used by cancer cells to evade apoptosis is the dysregulation of inhibitor of apoptosis (IAP) proteins. The activity of the IAPs is regulated by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::749eac6e33c3d6ae4c15d5416ec41d41
https://doi.org/10.1158/1535-7163.c.6536442.v1
https://doi.org/10.1158/1535-7163.c.6536442.v1
Autor:
Srinivas K. Chunduru, Mark A. McKinlay, Yigong Shi, David Weng, Martin A. Graham, Matthew D. Alexander, Thomas Haimowitz, Yu-Hua Lee, Pavan K. Tirunahari, Mukta S. Hendi, Yijun Deng, Susan R. Rippin, Matthew G. LaPorte, Gurpreet S. Kapoor, Martin E. Seipel, Guangyao Yu, Stephen M. Condon, Eric M. Neiman, Jennifer M. Burns, Yasuhiro Mitsuuchi, Christopher A. Benetatos
PDF file - 1384KB, Supplemental Figure 1. Structure of biotinylated birinapant Supplemental Figure 2. Concentration-dependent degradation of GFP-cIAP1/2 by birinapant Supplemental Figure 3. Representative examples of data analysis from 111 cell line
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77cfd31d3e0c71e37181fc6d9362974f
https://doi.org/10.1158/1535-7163.22500405.v1
https://doi.org/10.1158/1535-7163.22500405.v1
Autor:
Srinivas K. Chunduru, Mark A. McKinlay, Yigong Shi, David Weng, Martin A. Graham, Matthew D. Alexander, Thomas Haimowitz, Yu-Hua Lee, Pavan K. Tirunahari, Mukta S. Hendi, Yijun Deng, Susan R. Rippin, Matthew G. LaPorte, Gurpreet S. Kapoor, Martin E. Seipel, Guangyao Yu, Stephen M. Condon, Eric M. Neiman, Jennifer M. Burns, Yasuhiro Mitsuuchi, Christopher A. Benetatos
PDF file - 73KB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6017e6fd5bb940ccaf18ea18c0384148
https://doi.org/10.1158/1535-7163.22500408.v1
https://doi.org/10.1158/1535-7163.22500408.v1
Autor:
Srinivas K. Chunduru, Mark A. McKinlay, Yigong Shi, David Weng, Martin A. Graham, Matthew D. Alexander, Thomas Haimowitz, Yu-Hua Lee, Pavan K. Tirunahari, Mukta S. Hendi, Yijun Deng, Susan R. Rippin, Matthew G. LaPorte, Gurpreet S. Kapoor, Martin E. Seipel, Guangyao Yu, Stephen M. Condon, Eric M. Neiman, Jennifer M. Burns, Yasuhiro Mitsuuchi, Christopher A. Benetatos
XLS file - 45KB, Sensitivity of a 111 cell line panel to birinapant as a single agent and in combination with TNF or TRAIL.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77a5608cfd12aa98c693523b28ad5a19
https://doi.org/10.1158/1535-7163.22500402.v1
https://doi.org/10.1158/1535-7163.22500402.v1
Publikováno v:
ACS Med Chem Lett
[Image: see text] JP4-039 is an alkene peptide isostere that acts as a low-micromolar inhibitor of erastin- and RSL-3-induced ferroptotic cell death in the HT-1080 cell line. In this work, we have developed new synthetic strategies that allow access
Publikováno v:
Synlett. 30:471-476
A four-step synthesis of the FDA-approved anticancer agent gefitinib was developed starting from 2,4-dichloro-6,7-dimethoxyquinazoline. Reaction temperatures were highly practical (0–55 °C), and chromatographic purifications were avoided. The ioni