Výsledky vyhledávání - "Matthew G. Hickman"

Lack of insulin resistance in fibroblasts from subjects with polycystic ovary syndrome

Autor: Theodore P. Ciaraldi, Samuel S. C. Yen, Arlene J. Morales, Rosanne Odom-Ford, Jerrold M. Olefsky, Matthew G. Hickman

Publikováno v: Metabolism. 47:940-946

Insulin resistance in polycystic ovary syndrome (PCOS) is characterized by a novel defect in insulin signal transduction expressed in isolated human adipocytes as impaired insulin sensitivity for glucose transport and antilipolysis. To determine whet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a126fdbbe8190860187e3275d9da5973
https://doi.org/10.1016/s0026-0495(98)90348-1

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Insulin Signal Transduction by a Mutant Human Insulin Receptor Lacking the NPEY Sequence

Autor: Celia Anderson, Matthew G. Hickman, Paulos Berhanu, Theodore P. Ciaraldi

Publikováno v: Journal of Biological Chemistry. 272:22884-22890

The cytoplasmic juxtamembrane domain of the human insulin receptor (hIR) contains a single copy of the tetrameric amino acid sequence Asn-Pro-Glu-Tyr (NPEY) (residues 969-972 in the exon 11-containing B-isoform), which exists in the context of NPXY.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::21543da364e8c1bdea2500b274e8b246
https://doi.org/10.1074/jbc.272.36.22884

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Cellular Insulin Resistance in Adipocytes from Obese Polycystic Ovary Syndrome Subjects Involves Adenosine Modulation of Insulin Sensitivity1

Autor: Theodore P. Ciaraldi, Matthew G. Hickman, Jerrold M. Olefsky, Samuel S. C. Yen, Arlene J. Morales, Rosanne Odom-Ford

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 82:1421-1425

Cellular insulin resistance in polycystic ovary syndrome (PCOS) has been shown to involve a novel postbinding defect in insulin signal transduction. To find possible mechanisms for this defect, adipocytes were isolated from age- and weight-matched ob

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a1a829af53a157c3419663c911e305a1
https://doi.org/10.1210/jcem.82.5.3961

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Low-carbohydrate diet alters intracellular glucose metabolism but not overall glucose disposal in exercise-trained subjects

Autor: Matthew G. Hickman, Sung W. Park, David L. Cutler, Charles G. Gray, J M Bell, Orville G. Kolterman

Publikováno v: Metabolism. 44:1264-1270

Dietary composition has been strongly implicated as an important determinant of in vivo insulin sensitivity. However, the metabolic alterations associated with extreme changes in diet have not been well described. We compared glucose metabolism after

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e6dde074b687e387c888e5698cb15d2
https://doi.org/10.1016/0026-0495(95)90027-6

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Regulation of glucose transport in cultured muscle cells by novel hypoglycemic agents

Autor: Matthew G. Hickman, Theodore P. Ciaraldi, Jerrold M. Olefsky, Kathleen Huber-Knudsen

Publikováno v: Metabolism: clinical and experimental. 44(8)

The antidiabetic agent troglitazone (CS-045) and a metabolite designated M3 have potent blood glucose-lowering actions. The mechanism of the hypoglycemic effects of troglitazone and M3 was investigated in cultured L6 muscle cells. Short-term (2-hour)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b4fba935277430b382a406e771dc005
https://pubmed.ncbi.nlm.nih.gov/7637655

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