Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Matthew G McDonald"'
Autor:
Rachel Dalton, Seung‐been Lee, Katrina G. Claw, Bhagwat Prasad, Brian R. Phillips, Danny D. Shen, Lai Hong Wong, Mitch Fade, Matthew G. McDonald, Maitreya J. Dunham, Douglas M. Fowler, Allan E. Rettie, Erin Schuetz, Timothy A. Thornton, Deborah A. Nickerson, Andrea Gaedigk, Kenneth E. Thummel, Erica L. Woodahl
Publikováno v:
Clinical and Translational Science, Vol 13, Iss 1, Pp 147-156 (2020)
The cytochrome P450 2D6 (CYP2D6) gene locus is challenging to accurately genotype due to numerous single nucleotide variants and complex structural variation. Our goal was to determine whether the CYP2D6 genotype‐phenotype correlation is improved w
Externí odkaz:
https://doaj.org/article/16a9484280914410be57114d167f3ce5
Autor:
Matthew G. McDonald, Catherine K. Yeung, Aaron M. Teitelbaum, Amanda L. Johnson, Shinya Fujii, Hiroyuki Kagechika, Allan E. Rettie
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 4, Pp 892-899 (2019)
Vitamin K (VK), in both its phylloquinone and menaquinone forms, has been hypothesized to undergo ω- and β-oxidation on its hydrophobic side chain in order to generate the observed urinary metabolites, K acid I and K acid II, which are excreted pri
Externí odkaz:
https://doaj.org/article/f76ce9485fad4bcdba19644badf8ed00
Autor:
Katherine A. Sitko, Lai Hong Wong, Allan E. Rettie, Gabriel Boyle, Clara J. Amorosi, John P. Kowalski, Melissa A Chiasson, Douglas M. Fowler, Maitreya J. Dunham, Matthew G. McDonald
Publikováno v:
Am J Hum Genet
CYP2C9 encodes a cytochrome P450 enzyme responsible for metabolizing up to 15% of small molecule drugs, and CYP2C9 variants can alter the safety and efficacy of these therapeutics. In particular, the anti-coagulant warfarin is prescribed to over 15 m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::246f02008e4beb6e3257ac1171b8faf7
https://doi.org/10.1016/j.ajhg.2021.07.001
https://doi.org/10.1016/j.ajhg.2021.07.001
Publikováno v:
Drug Metab Dispos
Botanical and other natural products (NPs) are often coconsumed with prescription medications, presenting a risk for cytochrome P450 (P450)-mediated NP-drug interactions. The NP goldenseal (Hydrastis canadensis) has exhibited antimicrobial activities
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::033bc14c6c869ed56de2918b9f548a5d
https://doi.org/10.1124/dmd.120.091041
https://doi.org/10.1124/dmd.120.091041
Autor:
Michele Scian, Dale Whittington, Matthew G. McDonald, Constanze Wiek, Miklos Guttman, Allan E. Rettie, John P. Kowalski, Marco Girhard, Helmut Hanenberg
Publikováno v:
Chemical Research in Toxicology. 32:2488-2498
Cytochrome P450 4B1 (CYP4B1) has been explored as a candidate enzyme in suicide gene systems for its ability to bioactivate the natural product 4-ipomeanol (IPO) to a reactive species that causes cytotoxicity. However, metabolic limitations of IPO ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ede64dbcf88b97c2ba557daa0505edb
https://doi.org/10.1021/acs.chemrestox.9b00330
https://doi.org/10.1021/acs.chemrestox.9b00330
Autor:
Seung-been Lee, Deborah A. Nickerson, Kenneth E. Thummel, Erin G. Schuetz, Allan E. Rettie, Maitreya J. Dunham, Andrea Gaedigk, Rachel Dalton, Bhagwat Prasad, Brian Phillips, Timothy A. Thornton, Erica L. Woodahl, Mitch Fade, Lai Hong Wong, Douglas M. Fowler, Matthew G. McDonald, Danny D. Shen, Katrina G. Claw
Publikováno v:
Clinical and Translational Science. 13:147-156
The cytochrome P450 2D6 (CYP2D6) gene locus is challenging to accurately genotype due to numerous single nucleotide variants and complex structural variation. Our goal was to determine whether the CYP2D6 genotype-phenotype correlation is improved whe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca41d56da6296c2ad1879fc1118c6fe6
https://doi.org/10.1111/cts.12695
https://doi.org/10.1111/cts.12695
Autor:
Aaron M. Teitelbaum, Catherine K. Yeung, Matthew G. McDonald, Allan E. Rettie, Amanda L. Johnson, Shinya Fujii, Hiroyuki Kagechika
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 4, Pp 892-899 (2019)
Vitamin K (VK), in both its phylloquinone and menaquinone forms, has been hypothesized to undergo ω- and β-oxidation on its hydrophobic side chain in order to generate the observed urinary metabolites, K acid I and K acid II, which are excreted pri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfaa07c32e9ebad4f8cdc11fb4eabbd5
https://doi.org/10.1194/jlr.d087916
https://doi.org/10.1194/jlr.d087916
Autor:
Judit Marsillach, Stephanie M Suzuki, Rebecca J Richter, Matthew G McDonald, Peter M Rademacher, Michael J MacCoss, Edward J Hsieh, Allan E Rettie, Clement E Furlong
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e110054 (2014)
Homocysteinylation of lysine residues by homocysteine thiolactone (HCTL), a reactive homocysteine metabolite, results in protein aggregation and malfunction, and is a well-known risk factor for cardiovascular, autoimmune and neurological diseases. Hu
Externí odkaz:
https://doaj.org/article/1fb2e390fbb54bd099f64d51bb0122ba
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 51(8)
8-[(1H-1,2,3-benzotriazol-1-yl)amino]octanoic acid (8-BOA) was recently identified as a selective and potent mechanism-based inactivator (MBI) of breast cancer-associated CYP4Z1 and exhibited favourable inhibitory activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::85503e3944544db1d341a47866085e5c
https://pubmed.ncbi.nlm.nih.gov/33993844
https://pubmed.ncbi.nlm.nih.gov/33993844
8‐[(1H‐1,2,3‐benzotriazol‐1‐yl)amino]octanoic acid (8-BOA) was recently identified as a selective and potent mechanism-based inactivator (MBI) of breast cancer-associated CYP4Z1 and exhibited favourable inhibitory activity in vitro, thus me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01b53bcc8bf55a84f9624d1c38c8807f
