Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Matthew G Cottingham"'
Autor:
Alexandra J Spencer, Julie Furze, Jared D Honeycutt, Alice Calvert, Saroj Saurya, Stefano Colloca, David H Wyllie, Sarah C Gilbert, Migena Bregu, Matthew G Cottingham, Adrian V S Hill
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e105520 (2014)
T cells play a central role in the immune response to many of the world's major infectious diseases. In this study we investigated the tumour necrosis factor receptor superfamily costimulatory molecule, 4-1BBL (CD137L, TNFSF9), for its ability to inc
Externí odkaz:
https://doaj.org/article/41a85d6642484a3f87c492b905df1385
Autor:
Alexandra J Spencer, Matthew G Cottingham, Jennifer A Jenks, Rhea J Longley, Stefania Capone, Stefano Colloca, Antonella Folgori, Riccardo Cortese, Alfredo Nicosia, Migena Bregu, Adrian V S Hill
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100538 (2014)
The orthodox role of the invariant chain (CD74; Ii) is in antigen presentation to CD4+ T cells, but enhanced CD8+ T cells responses have been reported after vaccination with vectored viral vaccines encoding a fusion of Ii to the antigen of interest.
Externí odkaz:
https://doaj.org/article/03a908736103413081ed60360973a6cb
Autor:
Matthew D J Dicks, Alexandra J Spencer, Nick J Edwards, Göran Wadell, Kalifa Bojang, Sarah C Gilbert, Adrian V S Hill, Matthew G Cottingham
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40385 (2012)
Recombinant adenoviruses are among the most promising tools for vaccine antigen delivery. Recently, the development of new vectors has focused on serotypes to which the human population is less exposed in order to circumvent pre-existing anti vector
Externí odkaz:
https://doaj.org/article/e7199a2be3424c0ea10dfbee38ad80e6
Autor:
Emily K Forbes, Simone C de Cassan, David Llewellyn, Sumi Biswas, Anna L Goodman, Matthew G Cottingham, Carole A Long, Richard J Pleass, Adrian V S Hill, Fergal Hill, Simon J Draper
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44943 (2012)
Viral vectored vaccines have been shown to induce both T cell and antibody responses in animals and humans. However, the induction of even higher level T cell responses may be crucial in achieving vaccine efficacy against difficult disease targets, e
Externí odkaz:
https://doaj.org/article/719274f23ed642f7aad4a511239adc4b
Autor:
Alexandra J Spencer, Fergal Hill, Jared D Honeycutt, Matthew G Cottingham, Migena Bregu, Christine S Rollier, Julie Furze, Simon J Draper, Karen C Søgaard, Sarah C Gilbert, David H Wyllie, Adrian V S Hill
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33555 (2012)
To prevent important infectious diseases such as tuberculosis, malaria and HIV, vaccines inducing greater T cell responses are required. In this study, we investigated whether fusion of the M. tuberculosis antigen 85A to recently described adjuvant I
Externí odkaz:
https://doaj.org/article/137f82f36b9a4357985e9289f6ebe5fc
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e40167 (2012)
CD8(+) T cell responses to vaccinia virus are directed almost exclusively against early gene products. The attenuated strain modified vaccinia virus Ankara (MVA) is under evaluation in clinical trials of new vaccines designed to elicit cellular immun
Externí odkaz:
https://doaj.org/article/637a937165534b80ab7489b613ec72bf
Autor:
Sumi Biswas, Matthew D J Dicks, Carole A Long, Edmond J Remarque, Loredana Siani, Stefano Colloca, Matthew G Cottingham, Anthony A Holder, Sarah C Gilbert, Adrian V S Hill, Simon J Draper
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20977 (2011)
Apical membrane antigen 1 (AMA1) is a leading candidate vaccine antigen against blood-stage malaria, although to date numerous clinical trials using mainly protein-in-adjuvant vaccines have shown limited success. Here we describe the pre-clinical dev
Externí odkaz:
https://doaj.org/article/e1e19999e3bb411eb39bb44739b71733
Autor:
Matthew G Cottingham, Rikke F Andersen, Alexandra J Spencer, Saroj Saurya, Julie Furze, Adrian V S Hill, Sarah C Gilbert
Publikováno v:
PLoS ONE, Vol 3, Iss 2, p e1638 (2008)
The production, manipulation and rescue of a bacterial artificial chromosome clone of Vaccinia virus (VAC-BAC) in order to expedite construction of expression vectors and mutagenesis of the genome has been described (Domi & Moss, 2002, PNAS99 12415-2
Externí odkaz:
https://doaj.org/article/a58c3e88c42e420fbe8b9b750ad4f853
Publikováno v:
European Child & Adolescent Psychiatry
Children, adolescents and adults with attention-deficit/hyperactivity disorder (ADHD) experience functional impairment and poor health-related quality of life (HRQoL) in addition to symptoms of inattention/hyperactivity–impulsivity. To synthesize q
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::741b8e0428df16dad41f7c83a5f49679
http://europepmc.org/articles/PMC5656703
http://europepmc.org/articles/PMC5656703
Autor:
Benedict R. Halbroth, Sarah Sebastian, Hazel C. Poyntz, Migena Bregu, Matthew G. Cottingham, Adrian V. S. Hill, Alexandra J. Spencer
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Despite promising progress in malaria vaccine development, an efficacious subunit vaccine against P. falciparum remains to be licensed and deployed. This study aimed to improve on the immunogenicity of the leading liver-stage vaccine candidate (ChAd6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6386b9e09a8c5a1707449a047bb1c061
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