Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Matthew G, Holt"'
Autor:
Araks Martirosyan, Rizwan Ansari, Francisco Pestana, Katja Hebestreit, Hayk Gasparyan, Razmik Aleksanyan, Silvia Hnatova, Suresh Poovathingal, Catherine Marneffe, Dietmar R. Thal, Andrew Kottick, Victor J. Hanson-Smith, Sebastian Guelfi, William Plumbly, T. Grant Belgard, Emmanouil Metzakopian, Matthew G. Holt
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-24 (2024)
Abstract Parkinson’s Disease (PD) is the second most common neurodegenerative disorder. The pathological hallmark of PD is loss of dopaminergic neurons and the presence of aggregated α-synuclein, primarily in the substantia nigra pars compacta (SN
Externí odkaz:
https://doaj.org/article/ac5a812e7fc64915b2e68e33cecdd4a4
Autor:
Araks Martirosyan, Rizwan Ansari, Francisco Pestana, Katja Hebestreit, Hayk Gasparyan, Razmik Aleksanyan, Silvia Hnatova, Suresh Poovathingal, Catherine Marneffe, Dietmar R. Thal, Andrew Kottick, Victor J. Hanson-Smith, Sebastian Guelfi, William Plumbly, T. Grant Belgard, Emmanouil Metzakopian, Matthew G. Holt
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/5bf4088beae54ac38e53d043a1ffdfc6
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Astrocytes are the major glial cell type in the central nervous system (CNS). Initially regarded as supportive cells, it is now recognized that this highly heterogeneous cell population is an indispensable modulator of brain development and function.
Externí odkaz:
https://doaj.org/article/67188e91bb8d4bddb02281b42f5d6c0a
Autor:
Pierre Lemaitre, Samar HK Tareen, Emanuela Pasciuto, Loriana Mascali, Araks Martirosyan, Zsuzsanna Callaerts‐Vegh, Suresh Poovathingal, James Dooley, Matthew G Holt, Lidia Yshii, Adrian Liston
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 5, Pp n/a-n/a (2023)
Abstract Cognitive decline is a common pathological outcome during aging, with an ill‐defined molecular and cellular basis. In recent years, the concept of inflammaging, defined as a low‐grade inflammation increasing with age, has emerged. Infilt
Externí odkaz:
https://doaj.org/article/78934a3a099a43c781c47882cc383255
Autor:
Marika Marino, Lujia Zhou, Melvin Y Rincon, Zsuzsanna Callaerts‐Vegh, Jens Verhaert, Jérôme Wahis, Eline Creemers, Lidia Yshii, Keimpe Wierda, Takashi Saito, Catherine Marneffe, Iryna Voytyuk, Yessica Wouters, Maarten Dewilde, Sandra I Duqué, Cécile Vincke, Yona Levites, Todd E Golde, Takaomi C Saido, Serge Muyldermans, Adrian Liston, Bart De Strooper, Matthew G Holt
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 4, Pp 1-21 (2022)
Abstract Single domain antibodies (VHHs) are potentially disruptive therapeutics, with important biological value for treatment of several diseases, including neurological disorders. However, VHHs have not been widely used in the central nervous syst
Externí odkaz:
https://doaj.org/article/10d3c6ff5fb2440ca2d3a9bf9989e4aa
Autor:
Caroline Eykens, Elisabeth Rossaert, Sandra Duqué, Laura Rué, André Bento-Abreu, Nicole Hersmus, Annette Lenaerts, Axelle Kerstens, Nikky Corthout, Sebastian Munck, Philip Van Damme, Matthew G. Holt, Georg von Jonquires, Matthias Klugmann, Ludo Van Den Bosch, Wim Robberecht
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss , Pp 508-519 (2021)
Oligodendrocyte dysfunction has been implicated in the pathophysiology of amyotrophic lateral sclerosis (ALS), a neurodegenerative disorder characterized by progressive motor neuron loss. The failure of trophic support provided by oligodendrocytes is
Externí odkaz:
https://doaj.org/article/5b90cd6bd1ee48538c98aa1f5b5b50c6
Autor:
Marika Marino, Matthew G. Holt
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
In the last four decades, monoclonal antibodies and their derivatives have emerged as a powerful class of therapeutics, largely due to their exquisite targeting specificity. Several clinical areas, most notably oncology and autoimmune disorders, have
Externí odkaz:
https://doaj.org/article/5247189cbc7d42c3bc13e33dfe70233a
Autor:
Lutgarde Serneels, Dries T’Syen, Laura Perez-Benito, Tom Theys, Matthew G. Holt, Bart De Strooper
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-11 (2020)
Abstract Background Three amino acid differences between rodent and human APP affect medically important features, including β-secretase cleavage of APP and Aβ peptide aggregation (De Strooper et al., EMBO J 14:4932-38, 1995; Ueno et al., Biochemis
Externí odkaz:
https://doaj.org/article/e108c7bd5bc84cf6bf669c4ca6a637f0
Autor:
Mykhailo Y. Batiuk, Araks Martirosyan, Jérôme Wahis, Filip de Vin, Catherine Marneffe, Carola Kusserow, Jordan Koeppen, João Filipe Viana, João Filipe Oliveira, Thierry Voet, Chris P. Ponting, T. Grant Belgard, Matthew G. Holt
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Astrocytes are a major cell type in the central nervous system. Using single cell transcriptome sequencing, the authors identify multiple astrocyte subtypes in the adult mouse CNS, which map to distinct spatial locations and show correlations to cell
Externí odkaz:
https://doaj.org/article/22496d13c2df4885804f0b1ff03450bb
Autor:
João Filipe Viana, João Luís Machado, Daniela Sofia Abreu, Alexandra Veiga, Sara Barsanti, Gabriela Tavares, Manuella Martins, Vanessa Morais Sardinha, Sónia Guerra‐Gomes, Cátia Domingos, Alberto Pauletti, Jérôme Wahis, Chen Liu, Corrado Calì, Christian Henneberger, Matthew G. Holt, João Filipe Oliveira
Publikováno v:
Glia 71(7), 1667-1682 (2023). doi:10.1002/glia.24362
Astrocytes are integral components of brain circuits, where they sense, process, and respond to surrounding activity, maintaining homeostasis and regulating synaptic transmission, the sum of which results in behavior modulation. These interactions ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2ab4634e034ded0025122b7ee1a7786
https://doi.org/10.1002/glia.24362
https://doi.org/10.1002/glia.24362