Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Matthew G, Booty"'
Autor:
Matthew G. Booty, Kelan A. Hlavaty, Adam Stockmann, Emrah Ilker Ozay, Carolyne Smith, Lina Tian, Edylle How, Disha Subramanya, Anita Venkitaraman, Christian Yee, Olivia Pryor, Kelly Volk, Katarina Blagovic, Ildefonso Vicente-Suarez, Defne Yarar, Melissa Myint, Amy Merino, Jonathan Chow, Tarek Abdeljawad, Harry An, Sophia Liu, Shirley Mao, Megan Heimann, LeeAnn Talarico, Miye K. Jacques, Eritza Chong, Lucas Pomerance, John T. Gonzalez, Ulrich H. von Andrian, Klavs F. Jensen, Robert Langer, Hendrik Knoetgen, Christine Trumpfheller, Pablo Umaña, Howard Bernstein, Armon Sharei, Scott M. Loughhead
Publikováno v:
The Journal of Immunology. 208:929-940
CD8+ T cell responses are the foundation of the recent clinical success of immunotherapy in oncologic indications. Although checkpoint inhibitors have enhanced the activity of existing CD8+ T cell responses, therapeutic approaches to generate Ag-spec
Publikováno v:
PLoS Pathogens, Vol 12, Iss 1, p e1005380 (2016)
T cell vaccines against Mycobacterium tuberculosis (Mtb) and other pathogens are based on the principle that memory T cells rapidly generate effector responses upon challenge, leading to pathogen clearance. Despite eliciting a robust memory CD8+ T ce
Externí odkaz:
https://doaj.org/article/73c8b94c599041c29dbcae82b3573888
Autor:
Cláudio Nunes-Alves, Matthew G Booty, Stephen M Carpenter, Alissa C Rothchild, Constance J Martin, Danielle Desjardins, Katherine Steblenko, Henrik N Kløverpris, Rajhmun Madansein, Duran Ramsuran, Alasdair Leslie, Margarida Correia-Neves, Samuel M Behar
Publikováno v:
PLoS Pathogens, Vol 11, Iss 5, p e1004849 (2015)
The immune system can recognize virtually any antigen, yet T cell responses against several pathogens, including Mycobacterium tuberculosis, are restricted to a limited number of immunodominant epitopes. The host factors that affect immunodominance a
Externí odkaz:
https://doaj.org/article/b649e79c83074039910e479c4c31f14b
Autor:
Matthew G, Booty, Kelan A, Hlavaty, Adam, Stockmann, Emrah Ilker, Ozay, Carolyne, Smith, Lina, Tian, Edylle, How, Disha, Subramanya, Anita, Venkitaraman, Christian, Yee, Olivia, Pryor, Kelly, Volk, Katarina, Blagovic, Ildefonso, Vicente-Suarez, Defne, Yarar, Melissa, Myint, Amy, Merino, Jonathan, Chow, Tarek, Abdeljawad, Harry, An, Sophia, Liu, Shirley, Mao, Megan, Heimann, LeeAnn, Talarico, Miye K, Jacques, Eritza, Chong, Lucas, Pomerance, John T, Gonzalez, Ulrich H, von Andrian, Klavs F, Jensen, Robert, Langer, Hendrik, Knoetgen, Christine, Trumpfheller, Pablo, Umaña, Howard, Bernstein, Armon, Sharei, Scott M, Loughhead
Publikováno v:
J Immunol
CD8(+) T cell responses are the foundation of the recent clinical success of immunotherapy in oncologic indications. Although checkpoint inhibitors have enhanced the activity of existing CD8(+) T cell responses, therapeutic approaches to generate Ag-
Autor:
Katherine Seidl, Christian Klein, Adam Stockmann, Laura Codarri, Olivia Pryor, Christine Trumpfheller, Nicolini Valeria G, Matthew G. Booty, Pablo Umana, Armon Sharei, Melissa Myint, Scott Loughhead, Howard Bernstein
Publikováno v:
Regular and young investigator award abstracts.
Background We engineered unfractionated peripheral blood mononuclear cells (PBMCs) to function as antigen presenting cells (APCs) that generate potent CD8+ T cell responses. We investigated the combined efficacy of PBMC-based cancer vaccine with targ
Autor:
Olivia Pryor, Matthew G. Booty, Kelly Volk, Armon Sharei, Defne Yarar, Scott Loughhead, Emrah Ilker Ozay, Adam Stockmann, Katherine Seidl, David Soto, Howard Bernstein, Blagovic Katarina, Disha Subramanya
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background The presentation of sufficient antigen on major histocompatibility complex class I (MHC-I) is essential to prime CD8+ T cells. Methods To achieve efficient MHC-I presentation, we used microfluidics cell squeezing (Cell Squeeze®) to delive
Autor:
Stephen M. Carpenter, Cláudio Nunes-Alves, Matthew G. Booty, Pushpa Jayaraman, Samuel M. Behar
Publikováno v:
The Journal of Immunology. 196:1822-1831
The differentiation of effector CD8+ T cells is a dynamically regulated process that varies during different infections and is influenced by the inflammatory milieu of the host. In this study, we define three signals regulating CD8+ T cell responses
Publikováno v:
Seminars in Immunology. 26:559-577
Despite the introduction almost a century ago of Mycobacterium bovis BCG (BCG), an attenuated form of M. bovis that is used as a vaccine against Mycobacterium tuberculosis, tuberculosis remains a global health threat and kills more than 1.5 million p
Autor:
Gillian Beamer, Cláudio Nunes-Alves, Matthew G. Booty, Britni L. Stowell, Palmira Barreira-Silva, Samuel M. Behar, Pushpa Jayaraman, Stephen M. Carpenter, Miye K. Jacques
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Scientific Reports
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Scientific Reports
IL-21 is produced predominantly by activated CD4(+) T cells and has pleiotropic effects on immunity via the IL-21 receptor (IL-21R), a member of the common gamma chain (gamma(c)) cytokine receptor family. We show that IL-21 signaling plays a crucial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c6edaad0d48ce2cb1c6202ebeb8eea8
Autor:
Hlavaty Kelan, Vicente-Suarez Alfonso, Blagovic Katarina, Howard Bernstein, Matthew G. Booty, Scott Loughhead, Armon Sharei, Defne Yarar
Publikováno v:
Cancer Research. 79:3187-3187
Effective T cell priming is crucial to induce anti-tumor CD8+ T cell responses and requires the efficient presentation of antigen on major histocompatibility complex class I (MHC-I) by antigen presenting cells (APCs). Previous efforts using dendritic