Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Matthew Freer"'
Publikováno v:
Cells, Vol 13, Iss 22, p 1859 (2024)
Drug discovery is associated with high levels of compound elimination in all stages of development. The current practices for the pharmacokinetic testing of intestinal absorption combine Transwell® inserts with the Caco-2 cell line and are associate
Externí odkaz:
https://doaj.org/article/fc269f1ba98042aebbeef4189be66158
Autor:
Shaheda Sameena Ahmed, Mohammed Mahid Ahmed, Abbas Ishaq, Matthew Freer, Richard Stebbings, Anne Mary Dickinson
Publikováno v:
Toxics, Vol 12, Iss 6, p 401 (2024)
Biologics, including monoclonal antibodies (mAb), have proved to be effective and successful therapeutic agents, particularly in the treatment of cancer and immune-inflammatory conditions, as well as allergies and infections. However, their use carri
Externí odkaz:
https://doaj.org/article/36f4a02bc3bb45a083c2932ba4163f01
Autor:
Ana Martins-Ribeiro, Arathi Kizhedath, Shaheda Sameena Ahmed, Jarka Glassey, Abbas Ishaq, Matthew Freer, Anne Mary Dickinson
Publikováno v:
Toxics, Vol 12, Iss 5, p 332 (2024)
Introduction: Monoclonal antibodies (mAbs) are important therapeutics. However, the enhanced potential for aggregation has become a critical quality parameter during the production of mAbs. Furthermore, mAb aggregation may also present a potential he
Externí odkaz:
https://doaj.org/article/4f8d7ebf622d49cebe23c38ab9d5b513
Publikováno v:
Bioengineering & Translational Medicine, Vol 8, Iss 3, Pp n/a-n/a (2023)
Abstract Human skin equivalents (HSEs) are an increasingly popular research tool due to limitations associated with animal testing for dermatological research. They recapitulate many aspects of skin structure and function, however, many only contain
Externí odkaz:
https://doaj.org/article/31cc99ccd48e49e89dea67b44c3642a9
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
The Caco-2 monolayer is the most widely used in vitro model of the human intestinal mucosa to study absorption. However, models lack communication from other cells present in the native intestine, such as signals from fibroblasts in the lamina propri
Externí odkaz:
https://doaj.org/article/ab5a7094683f44feaf2f2662d315e039
Autor:
Lydia, Costello, Nicole, Darling, Matthew, Freer, Steven, Bradbury, Claire, Mobbs, Stefan, Przyborski
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2273
In vitro epithelial models are valuable tools for both academic and industrial laboratories to investigate tissue physiology and disease. Epithelial tissues comprise the surface epithelium, basement membrane, and underlying supporting stromal cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a53f84723e610fb0c8f391a875e15003
https://pubmed.ncbi.nlm.nih.gov/33604861
https://pubmed.ncbi.nlm.nih.gov/33604861
Autor:
Stefan Przyborski, Nicole Darling, Steven Bradbury, Lydia Costello, Matthew Freer, Claire L. Mobbs
Publikováno v:
Methods in Molecular Biology ISBN: 9781071612453
In vitro epithelial models are valuable tools for both academic and industrial laboratories to investigate tissue physiology and disease. Epithelial tissues comprise the surface epithelium, basement membrane, and underlying supporting stromal cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c05f49faff7e8689827c494ff766a4d8
https://doi.org/10.1007/978-1-0716-1246-0_20
https://doi.org/10.1007/978-1-0716-1246-0_20
Autor:
Lindsay Darling, Melissa Custic, Lydia Scott, Joseph McCarthy, Karen Ann Miller, Matthew Freer
Publikováno v:
Cities and the Environment. 13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5386d568bae738031f529f9ee0298e44
https://doi.org/10.15365/cate.2020.130106
https://doi.org/10.15365/cate.2020.130106
Autor:
Joseph McCarthy, Lydia Scott, Melissa Custic, Lindsay Darling, Karen Ann Miller, Matthew Freer
Publikováno v:
Cities and the Environment. 13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a030592f14f649bc4eec1858ab482a5f
https://doi.org/10.15365/cate.2020.130119
https://doi.org/10.15365/cate.2020.130119