Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Matthew Fowler-Watters"'
Autor:
Leo A. Joyce, Zhen Li, Pankaj Kumar, Michael Lawler, Erich Altenhofer, Tao Pei, Matthew Fowler-Watters
Publikováno v:
Chemical Communications. 57:6808-6811
The inherent in vivo instability of oligonucleotides presents one of many challenges in the development of RNAi-based therapeutics. Chemical modification to the 5'-terminus serves as an existing paradigm which can make phosphorylated antisense strand
Autor:
Holly Hamilton, Aaron Andersen, Josh Schumacher, Bruce D. Given, Anthony Nicholas, So C. Wong, Casi Schienebeck, Jeffrey C. Carlson, Matthew Fowler-Watters, Che Liu, Amanda Frankiewicz, B. Chen, Dongxu Shu, Li Xiaokai, Zhen Li, Julia Hegge, Stephanie Bertin, Rui Chu
Publikováno v:
Cancer Research. 79:4775-4775
Background: Clear cell renal cell carcinoma (ccRCC) frequently involves the inactivation of the von Hippel-Lindau (VHL) tumor suppressor. Loss of VHL functions lead to the accumulation of hypoxia-inducible factors (HIFs). HIF2α has been regarded as