Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Matthew F. Gorman"'
Autor:
Satheesh Chonat, Mary Risinger, Haripriya Sakthivel, Omar Niss, Jennifer A. Rothman, Loan Hsieh, Stella T. Chou, Janet L. Kwiatkowski, Eugene Khandros, Matthew F. Gorman, Donald T. Wells, Tamara Maghathe, Neha Dagaonkar, Katie G. Seu, Kejian Zhang, Wenying Zhang, Theodosia A. Kalfa
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Externí odkaz:
https://doaj.org/article/840996a63d2c4519a193f1ac68e710b4
Autor:
Satheesh Chonat, Mary Risinger, Haripriya Sakthivel, Omar Niss, Jennifer A. Rothman, Loan Hsieh, Stella T. Chou, Janet L. Kwiatkowski, Eugene Khandros, Matthew F. Gorman, Donald T. Wells, Tamara Maghathe, Neha Dagaonkar, Katie G. Seu, Kejian Zhang, Wenying Zhang, Theodosia A. Kalfa
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Hereditary spherocytosis (HS) is the most common red blood cell (RBC) membrane disorder causing hereditary hemolytic anemia. Patients with HS have defects in the genes coding for ankyrin (ANK1), band 3 (SLC4A1), protein 4.2 (EPB42), and α (SPTA1) or
Externí odkaz:
https://doaj.org/article/ad840012f1744b04820b5b66c13c0ebd
Autor:
Richard H. Ko, Clare J. Twist, Mignon L. Loh, Nita L. Seibel, Raymond J. Hutchinson, Paul S. Gaynon, Lingyun Ji, Matthew F. Gorman, Bruce Bostrom, Elena Eckroth, Phillip Barnette, Richard Sposto, Elizabeth A. Raetz
Publikováno v:
Pediatric Blood & Cancer. 55:421-429
Background Current event-free survival (EFS) rates for children with newly diagnosed acute myeloid leukemia (AML) approach 50–60%. We hypothesize that further improvements in survival are unlikely to be achieved with traditional approaches such as
Publikováno v:
Blood, vol 120, iss 21
3295 Patients with abnormal bleeding are frequently referred to specialists for evaluation of bleeding diatheses. For many patients with strong clinical evidence of a bleeding disorder (positive personal and family history of bleeding), a clear diagn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6271fcedfb78ad573088a1a712628d13
https://escholarship.org/uc/item/8hb7r5j4
https://escholarship.org/uc/item/8hb7r5j4
Autor:
Jennifer O. Lauchle, Kevin Shannon, Jon Akutagawa, Benjamin S. Braun, Natalya Lyubynska, Matthew F. Gorman, Wan Xing Hong
Publikováno v:
Science Translational Medicine. 3
Chronic and juvenile myelomonocytic leukemias (CMML and JMML) are aggressive myeloproliferative neoplasms that are incurable with conventional chemotherapy. Mutations that deregulate Ras signaling play a central pathogenic role in both disorders, and
Autor:
Kegan Warner, Ernesto Diaz-Flores, Jeannette M. Bonifas, Mary Tran, Doan T. Le, Matthew F. Gorman, Neal G. Copeland, Luis F. Parada, Linda Wolff, Keiko Akagi, Kevin Shannon, Michael Crone, Sally Przybranowski, Judith Sebolt-Leopold, Jeroen P. Roose, Jennifer O. Lauchle, Scott C. Kogan, Doris Kim, Nancy A. Jenkins, Qing Li, Kimberly Krisman, Kristen M Coakley
Publikováno v:
Nature
In a mouse model for myeloproliferative disorder (MPD) driven by loss of NF-1 (which activates the Ras–MEK–MAPK pathway), additional mutations were created by insertional mutagenesis that led to progression of the disease to acute myeloid leukaem
Publikováno v:
Clinical Endocrine Oncology, Second Edition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e99ffff4c740debfb7d6824822cd1df
https://doi.org/10.1002/9781444300222.ch43
https://doi.org/10.1002/9781444300222.ch43
Autor:
Keiko Akagi, Jennifer O. Lauchle, Kevin Shannon, Judith Sebolt-Leopold, Mary Tran, Neal G. Copeland, Luis F. Parada, Matthew F. Gorman, Linda Wolff, Doris Kim, Nancy A. Jenkins, Doan T. Le
Publikováno v:
Blood. 110:594-594
Hyperactive Ras is a common feature of many cancers, including myelodysplastic syndrome (MDS), myeloproliferative disease (MPD), and acute myeloid leukemia (AML). Conditional inactivation of the Nf1 tumor suppressor, which encodes a GTPase activating