Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Matthew F. Dunn"'
Autor:
David J. Edmonds, Shawn D. Doran, Dongxiang Zeng, Elnaz Menhaji-Klotz, Kathrine Loomis, Jana Polivkova, Kevin B. Bahnck, Tereece Banks, Dianna E. Moore, David A. Griffith, James A. Southers, Matthew F. Dunn, Aaron C. Smith, Carmen N. Garcia-Irizarry, Cathy Préville, William P. Esler, Kirk McPherson, Alan M. Mathiowetz, Paul A. Amor, David A. Beebe, Robert L. Dow, Scott W. Bagley, Kim Huard
Publikováno v:
Journal of Medicinal Chemistry. 56:7110-7119
Acetyl-CoA carboxylase (ACC) catalyzes the rate-determining step in de novo lipogenesis and plays a crucial role in the regulation of fatty acid oxidation. Alterations in lipid metabolism are believed to contribute to insulin resistance; thus inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40cff94b0e675bc3976fd9e44bb5a85d
https://doi.org/10.1021/jm401033t
https://doi.org/10.1021/jm401033t
Autor:
Karl O.A. Yu, Mitchell Kronenberg, Douglas P Izmirian, Amy R. Howell, Archana Khurana, Stewart K Richardson, Steven A Porcelli, Matthew F Dunn, Rachel M. Ndonye
Publikováno v:
The Journal of Organic Chemistry. 70:10260-10270
[structures: see text] The phytosphingosine-containing alpha-galactosylceramides (alpha-GalCers), KRN7000 and OCH, have been shown to activate NKT cells via interaction with CD1d, a member of the CD1 family of antigen presenting proteins. Evidence fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f0a15945f7ec2bdda1e7c24d173861c
https://doi.org/10.1021/jo051147h
https://doi.org/10.1021/jo051147h
Autor:
Chiliu Chen, Gregory Storer, Vishal Khot, Maria A. Vanvolkenburg, Kimberly O. Cameron, Kimberly Lapham, Kim M. Andrews, Suvi T. M. Orr, V. Margaret Jackson, Jigna D. Patel, Matthew F. Dunn, Jimmy Kong, Jun Xiao, Colin R. Rose, Hua Gao, Samit Kumar Bhattacharya, Allyn T. Londregan, David Hepworth, Dilinie P. Fernando, James Saenz, Ingrid A. Stock, Yingxin Zhang, Guoqiang Wang, Rachel E. Kosa, Kim F. McClure, Derek Vrieze, Paula M. Loria, Beveridge Ramsay
The identification of potent, highly selective orally bioavailable ghrelin receptor inverse agonists from a spiro-azetidino-piperidine series is described. Examples from this series have promising in vivo pharmacokinetics and increase glucose-stimula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3800063dbef9c77e57f42a33e1bfbcb
https://europepmc.org/articles/PMC4027753/
https://europepmc.org/articles/PMC4027753/
Autor:
Emma L. Blaney, David A. Griffith, Jeffrey T. Kohrt, Cathy Préville, James A. Southers, Scott W. Bagley, David J. Edmonds, Aaron C. Smith, Kim Huard, Matthew F. Dunn, Elnaz Menhaji-Klotz, Nigel M. Allanson, Robert L. Dow, Carmen N. Garcia-Irizarry, John C. Lucas
Publikováno v:
The Journal of organic chemistry. 77(22)
The synthesis of 4′,6′-dihydrospiro[piperidine-4,5′-pyrazolo[3,4-c]pyridin]-7′(2′H)-one-based acetyl-CoA carboxylase inhibitors is reported. The hitherto unknown N-2 tert-butyl pyrazolospirolactam core was synthesized from ethyl 3-amino-1H-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc67fd6c7915caac39c75274da65480d
https://pubmed.ncbi.nlm.nih.gov/23127254
https://pubmed.ncbi.nlm.nih.gov/23127254
Autor:
Matthew F. Dunn, John Charles Kath, Anil Mistry, F. Christopher Bi, Daniel Tyler Richter, Sabrina X. Zhao, Leonard Buckbinder, Jacquelyn Klug-McLeod, Daniel W. Kung, Gary Erik Aspnes, Michael P. Zawistoski, Robert M. Oliver, Seungil Han, Peter C. Bonnette, Ethan Ung, Molly A. McGlynn, Angel Guzman-Perez, Catherine Angela Hulford, Matthew C. Griffor, John R. Soglia, Jonathan N. Bauman, Michael Joseph Luzzio, Daniel P. Walker, Christopher Autry, Amit S. Kalgutkar, W. Gregory Roberts, Jian-Cheng Li, Beth Cooper
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(23)
The synthesis and SAR for a series of diaminopyrimidines as PYK2 inhibitors are described. Using a combination of library and traditional medicinal chemistry techniques, a FAK-selective chemical series was transformed into compounds possessing good P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65d4e40768ab5124987956906e550066
https://pubmed.ncbi.nlm.nih.gov/18951788
https://pubmed.ncbi.nlm.nih.gov/18951788
Publikováno v:
MRS Proceedings. 703
Hydroxyapetite (HA) coating on medical implant has been used in commercial application for several decades. The coating, commercially made by thermal spray method, functions as a intermediate layer between human tissues and the metal implant. The coa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa55c93f8ef0d346486374edd5b91297
https://doi.org/10.1557/proc-703-v7.5
https://doi.org/10.1557/proc-703-v7.5