Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Matthew F. Bush"'
Autor:
Guangfeng Zhou, Domnita-Valeria Rusnac, Hahnbeom Park, Daniele Canzani, Hai Minh Nguyen, Lance Stewart, Matthew F. Bush, Phuong Tran Nguyen, Heike Wulff, Vladimir Yarov-Yarovoy, Ning Zheng, Frank DiMaio
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Structure-based virtual screening is a key tool in early drug discovery, with growing interest in the screening of multi-billion chemical compound libraries. However, the success of virtual screening crucially depends on the accuracy of the
Externí odkaz:
https://doaj.org/article/29a1302972a44e30ab683de7520641e9
Autor:
Emily L. Pruitt, Rutan Zhang, Dylan H. Ross, Nathaniel K. Ashford, Xi Chen, Francis Alonzo, Matthew F. Bush, Brian J. Werth, Libin Xu
Publikováno v:
mSphere, Vol 8, Iss 6 (2023)
ABSTRACTStaphylococcus aureus only synthesizes straight-chain saturated fatty acids (SCFAs) or branched-chain saturated fatty acids via the type II fatty acid synthesis (FASII) pathway, but as a highly adaptive pathogen, S. aureus can also utilize ho
Externí odkaz:
https://doaj.org/article/c835f30f3cbf4a7ab932dd1f826ef968
Publikováno v:
ASPET 2023 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00f36e28dad582dd4b2608d7a1c101b0
https://doi.org/10.1124/jpet.122.276480
https://doi.org/10.1124/jpet.122.276480
Autor:
Theresa A. Gozzo, Matthew F. Bush
Publikováno v:
Mass Spectrometry Reviews.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a438b19cc10f7140c57ed47448ab36c
https://doi.org/10.1002/mas.21847
https://doi.org/10.1002/mas.21847
Publikováno v:
Annual Review of Analytical Chemistry. 16
Recent developments in ion mobility (IM) technology have expanded the capability to separate and characterize gas-phase ions of biomolecules, especially when paired with mass spectrometry. This next generation of IM technology has been ushered in by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4981f4076c28d2f1bf61394420f43bf6
https://doi.org/10.1146/annurev-anchem-091522-031329
https://doi.org/10.1146/annurev-anchem-091522-031329
Native ion mobility (IM) mass spectrometry (MS) is used to probe the size, shape, and assembly of biomolecular complexes. IM-IM-MS can increase the amount of information available in structural studies by isolating subpopulations of structures for fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::802bb64525859e4c758527f476aba377
https://doi.org/10.26434/chemrxiv-2023-lsts3
https://doi.org/10.26434/chemrxiv-2023-lsts3
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Small heat-shock proteins (sHSPs) are a widely expressed family of ATP-independent molecular chaperones that are among the first responders to cellular stress. Mechanisms by which sHSPs delay aggregation of client proteins remain undefined. sHSPs hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0859adc28fbf65afe5d99034b6cfa9ef
https://doi.org/10.1073/pnas.2213765120
https://doi.org/10.1073/pnas.2213765120
Autor:
Christopher N Woods, Lindsey D Ulmer, Maria K Janowska, Natalie L Stone, Ellie I James, Miklos Guttman, Matthew F Bush, Rachel E Klevit
Small heat shock proteins (sHSPs) are chaperones whose importance in protein homeostasis is exemplified by dozens of missense mutations associated with tissue-specific disease states. Despite decades of studies, the structure, dynamics, and mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27f957b193fd5e65cd4d4016255409c6
https://doi.org/10.1101/2022.05.30.493970
https://doi.org/10.1101/2022.05.30.493970
Autor:
Abhigya Mookherjee, Sanjit S. Uppal, Matthew F. Bush, Miklos Guttman, Sarah E. Beasley, Rick Harkewicz
Publikováno v:
Anal Chem
Mass spectrometry (MS) has become a primary tool for identifying and quantifying biological molecules. In combination with other orthogonal techniques, such as gas-phase hydrogen/deuterium exchange (gHDX), MS is also capable of probing the structure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::476aa0766ddad824ae5fe5aab2d8d423
https://doi.org/10.1021/acs.analchem.0c00749
https://doi.org/10.1021/acs.analchem.0c00749
Publikováno v:
Anal Chem
Human cells make use of hundreds of unique ubiquitin E3 ligases to ensure proteome fidelity and control cellular functions by promoting protein degradation. These processes require exquisite selectivity, but the individual roles of most E3s remain po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44b98586c17be462170c7e976125ab7d
https://doi.org/10.1021/acs.analchem.9b02331
https://doi.org/10.1021/acs.analchem.9b02331