Zobrazeno 1 - 10 of 108 pro vyhledávání: '"Matthew F Mescher"'
1
Data from Enhancement of T-cell–Mediated Antitumor Response: Angiostatic Adjuvant to Immunotherapy against Cancer
Autor: Kevin H. Mayo, Arjan W. Griffioen, Michael A. Farrar, Matthew F. Mescher, Mirjam G.A. oude Egbrink, Yan Zhang, Flavia Popescu, Karolien Castermans, Kieng B. Vang, Ruud P.M. Dings
Purpose: Tumor-released proangiogenic factors suppress endothelial adhesion molecule (EAM) expression and prevent leukocyte extravasation into the tumor. This is one reason why immunotherapy has met with limited success in the clinic. We hypothesized
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1897464c422f968fc410e1ee79855db8
https://doi.org/10.1158/1078-0432.c.6518661.v1
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4
Evolutionarily conserved resistance to phagocytosis observed in melanoma cells is insensitive to upregulation of pro-phagocytic signals and to CD47 blockade
Autor: Daisuke Ito, Katie L. Anderson, Kristin M. Snyder, Matthew F. Mescher, Lauren J. Mills, Debra C. Lins, Aaron M. Ring, Kipp Weiskopf, Yoji Shimizu, Irving L. Weissman, Jaime F. Modiano, Nan Guo Ring
Publikováno v: Melanoma Research
Supplemental Digital Content is available in the text.
Therapeutic activation of macrophage phagocytosis has the ability to restrain tumour growth through phagocytic clearance of tumour cells and activation of the adaptive immune response. Our o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7f77ca86f8c4e2a11549fa4559622a5
https://doi.org/10.1097/cmr.0000000000000629
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5
Abstract A051: Melanoma displays an evolutionarily conserved resistance to upregulation of prophagocytic signals and to CD47 blockade
Autor: Jaime F. Modiano, Matthew F. Mescher, Debra C. Lins, Aaron M. Ring, Lauren J. Mills, Irving L. Weissman, Nan Guo Ring, Yoji Shimizu, Katie L. Anderson, Daisuke Ito, Kristin M. Snyder, Kipp Weiskopf
Publikováno v: Cancer Immunology Research. 7:A051-A051
Therapeutic activation of macrophage phagocytosis has the ability to restrain tumor growth through phagocytic clearance of tumor cells and activation of the adaptive immune response. Our objective for this study was to evaluate the effects of modulat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::37a85cc7430fb7c13708b88414583f71
https://doi.org/10.1158/2326-6074.cricimteatiaacr18-a051
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6
ICAM-1–Dependent Homotypic Aggregates Regulate CD8 T Cell Effector Function and Differentiation during T Cell Activation
Autor: Eisuke Domae, Matthew F. Mescher, Yoji Shimizu, Nicholas A. Zumwalde
Publikováno v: The Journal of Immunology. 191:3681-3693
A hallmark of T cell activation in vitro and in vivo is the clustering of T cells with each other via interaction of the LFA-1 integrin with ICAM-1. The functional significance of these homotypic aggregates in regulating T cell function remains unkno
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11dae1f5426154b52d947c73860266c7
https://doi.org/10.4049/jimmunol.1201954
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7
Cutting Edge: IL-12 and Type I IFN Differentially Program CD8 T Cells for Programmed Death 1 Re-expression Levels and Tumor Control
Autor: Matthew F. Mescher, Lynn M. Heltemes-Harris, Michael Y. Gerner, Brian T. Fife
Publikováno v: The Journal of Immunology. 191:1011-1015
Naive CD8 T cells proliferate in response to TCR and CD28 signals, but require IL-12 or type I IFN to survive and develop optimal effector functions. Although murine CTL generated in vitro in response to IL-12 or IFN-α had comparable effector functi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::011d8bb45a3ed3c76b8afb6515e6dbcf
https://doi.org/10.4049/jimmunol.1300652
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8
Autocrine IFN-γ Promotes Naive CD8 T Cell Differentiation and Synergizes with IFN-α To Stimulate Strong Function
Autor: Pujya Agarwal, Debra C. Lins, Julie M. Curtsinger, Matthew F. Mescher
Publikováno v: The Journal of Immunology. 189:659-668
Autocrine IFN-γ signaling is important for CD4 differentiation to Th1 effector cells, but it has been unclear whether it contributes to CD8 T cell differentiation. We show in this paper that naive murine CD8 T cells rapidly and transiently produce l
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cb9215e7a9a0f283fb498a6584557fbd
https://doi.org/10.4049/jimmunol.1102727
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10
Immunotherapy with autologous tumour antigen-coated microbeads (large multivalent immunogen), IL-2 and GM-CSF in dogs with spontaneous B-cell lymphoma
Autor: Jeffrey S. Miller, Jaime F. Modiano, Julie M. Curtsinger, Michael S. Henson, V. S. Larson, J. S. Klausner, Matthew F. Mescher
Publikováno v: Veterinary and Comparative Oncology. 9:95-105
Cytotoxic T-lymphocyte responses to subcellular antigens are enhanced when antigens are presented on cell-sized silica microbeads called large multivalent immunogens (LMIs). LMIs prepared with tumour cell membrane fragments have induced partial remis
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b81afd44ff38a80f6f15e95d87c9729
https://doi.org/10.1111/j.1476-5829.2010.00234.x
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