Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Matthew F, Calabrese"'
Autor:
David Jonathan Wasilko, Brian S. Gerstenberger, Kathleen A. Farley, Wei Li, Jennifer Alley, Mark E. Schnute, Ray J. Unwalla, Jorge Victorino, Kimberly K. Crouse, Ru Ding, Parag V. Sahasrabudhe, Fabien Vincent, Richard K. Frisbie, Alpay Dermenci, Andrew Flick, Chulho Choi, Gary Chinigo, James J. Mousseau, John I. Trujillo, Philippe Nuhant, Prolay Mondal, Vincent Lombardo, Daniel Lamb, Barbara J. Hogan, Gurdeep Singh Minhas, Elena Segala, Christine Oswald, Ian W. Windsor, Seungil Han, Mathieu Rappas, Robert M. Cooke, Matthew F. Calabrese, Gabriel Berstein, Atli Thorarensen, Huixian Wu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The CC chemokine receptor 6 (CCR6) is a potential target for chronic inflammatory diseases. Previously, we reported an active CCR6 structure in complex with its cognate chemokine CCL20, revealing the molecular basis of CCR6 activation. Here,
Externí odkaz:
https://doaj.org/article/91af6bd491994266b492f68b0994ea6e
Autor:
James Schiemer, Andrew Maxwell, Reto Horst, Shenping Liu, Daniel P. Uccello, Kris Borzilleri, Nisha Rajamohan, Matthew F. Brown, Matthew F. Calabrese
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Bridging covalent ligand discovery with chimeric degrader design has emerged as a mechanism to target proteins that lack enzymatic activity or are intractable. Here, the authors use biochemical and cellular tools to deconvolute the role of covalent m
Externí odkaz:
https://doaj.org/article/8332ec11fd3e488aa9daf64205146e29
Autor:
Dominic D.G Owens, Matthew E.R Maitland, Aliakbar Khalili Yazdi, Xiaosheng Song, Martin P. Schwalm, Raquel A.C Machado, Nicolas Bauer, Xu Wang, Magdalena M. Szewczyk, Cheng Dong, Aiping Dong, Peter Loppnau, Matthew F. Calabrese, Matthew S. Dowling, Jisun Lee, Justin I. Montgomery, Thomas N. O’Connell, Chakrapani Subramanyam, Feng Wang, Matthieu Schapira, Stefan Knapp, Masoud Vedadi, Jinrong Min, Gilles A. Lajoie, Dalia Barsyte-Lovejoy, Dafydd R. Owen, Caroline Schild-Poulter, Cheryl H. Arrowsmith
The CTLH complex is a multi-subunit ubiquitin ligase complex that recognizes substrates with Pro/N-degrons via the substrate receptor GID4. Recently, focus has turned to this complex as a potential mediator of targeted protein degradation, but the ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::756b8bd8412abe2d17623cbc6ce6d79d
https://doi.org/10.1101/2023.01.17.524225
https://doi.org/10.1101/2023.01.17.524225
Publikováno v:
Future Medicinal Chemistry. 13:1203-1226
Targeted protein degradation is a broad and expanding field aimed at the modulation of protein homeostasis. A focus of this field has been directed toward molecules that hijack the ubiquitin proteasome system with heterobifunctional ligands that recr
Autor:
Xidong Feng, Ye Che, Adam M. Gilbert, Reto Horst, Kris A. Borzilleri, Matthew Merrill Hayward, Carolyn A. Leverett, James Schiemer, Yilin Meng, Justin I. Montgomery, Matthew F. Calabrese, Mark C. Noe, Daniel P. Uccello, Stephen P. Brown, Matthew Frank Brown, Yingrong Xu
Publikováno v:
Nature Chemical Biology. 17:152-160
Heterobifunctional chimeric degraders are a class of ligands that recruit target proteins to E3 ubiquitin ligases to drive compound-dependent protein degradation. Advancing from initial chemical tools, protein degraders represent a mechanism of growi
Autor:
James, Schiemer, Reto, Horst, Yilin, Meng, Justin I, Montgomery, Yingrong, Xu, Xidong, Feng, Kris, Borzilleri, Daniel P, Uccello, Carolyn, Leverett, Stephen, Brown, Ye, Che, Matthew F, Brown, Matthew M, Hayward, Adam M, Gilbert, Mark C, Noe, Matthew F, Calabrese
Publikováno v:
Nature chemical biology. 17(2)
Heterobifunctional chimeric degraders are a class of ligands that recruit target proteins to E3 ubiquitin ligases to drive compound-dependent protein degradation. Advancing from initial chemical tools, protein degraders represent a mechanism of growi
Autor:
Gregory S. Walker, Kimberly O. Cameron, Janice A. Brown, Daniel W. Kung, Angela Wolford, Heather Eng, Kris A. Borzilleri, Jake Delmore, Jessica Ward, David J. Edmonds, Amit S. Kalgutkar, Russell A. Miller, Tim F. Ryder, Allan R. Reyes, Ravi G. Kurumbail, Matthew F. Calabrese
Publikováno v:
Journal of Medicinal Chemistry. 61:7273-7288
Studies on indole-3-carboxylic acid derivatives as direct activators of human adenosine monophosphate-activated protein kinase (AMPK) α1β1γ1 isoform have culminated in the identification of PF-06409577 (1), PF-06885249 (2), and PF-06679142 (3) as
Autor:
Paul DaSilva-Jardine, Jessica Ward, Katherine Cialdea, Matthew F. Calabrese, Marina Amaro, Harmeet Gandhok, Francis Rajamohan, Alan C. Opsahl, Mara Monetti, Kimberly O. Cameron, Tim Rolph, Eliza Bollinger, Benjamin S. Maciejewski, Ravi G. Kurumbail, Christopher T. Salatto, Timothy M. Coskran, David A. Tess, Aditi Jatkar, Nathan E. Genung, Emily Cokorinos, Allan R. Reyes, Morris J. Birnbaum, Germaine Boucher, John M. Kreeger, Andre Shavnya, David J. Edmonds, Russell A. Miller, Amit S. Kalgutkar
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 361:303-311
Diabetic nephropathy remains an area of high unmet medical need, with current therapies that slow down, but do not prevent, the progression of disease. A reduced phosphorylation state of adenosine monophosphate-activated protein kinase (AMPK) has bee
Publikováno v:
Nature Reviews Drug Discovery. 18
Proteolysis-targeting chimeras (PROTACs) and related molecules that induce targeted protein degradation by the ubiquitin-proteasome system represent a new therapeutic modality and are the focus of great interest, owing to potential advantages over tr
Autor:
Jane M. Withka, Daniel W. Kung, Russell A. Miller, Matthew S. Dowling, Aaron C. Smith, Angela Wolford, Heather Eng, Janice A. Brown, Jun Xiao, Kris A. Borzilleri, Ravi G. Kurumbail, David J. Edmonds, Jessica Ward, Amit S. Kalgutkar, Colin R. Rose, Tim F. Ryder, Meihua Tu, Dilinie P. Fernando, Emily Cokorinos, David Hepworth, James A. Landro, Kimberly O. Cameron, Matthew F. Calabrese, Christopher T. Salatto, Francis Rajamohan, Andre Shavnya, Markus Boehm, Yuxia Mao, Allan R. Reyes, Richard K. Frisbie, Nicole Caspers, Edward L. Conn, Samit Kumar Bhattacharya
Publikováno v:
Journal of Medicinal Chemistry. 59:8068-8081
Adenosine monophosphate-activated protein kinase (AMPK) is a protein kinase involved in maintaining energy homeostasis within cells. On the basis of human genetic association data, AMPK activators were pursued for the treatment of diabetic nephropath